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Davide Mauri Sofia Roumbkou Stella Michalopoulou Lamprini Tsali Anastasia Spiliopoulou Charalampos Panou Antonis Valachis Angelos Panagopoulos Nikolaos P. Polyzos 《Medical oncology (Northwood, London, England)》2010,27(4):1309-1313
Central venous catheters (CVCs) are commonly used for the administration of intravenous chemotherapy in outpatient setting.
Nevertheless, outbreaks of catheter-associated bloodstream infections had been reported from oncology centers. We describe
a large outbreak of CVCs-associated Klebsiella oxytoca bloodstream infection, occurring in an oncology chemotherapy outpatient unit of northern Greece between October 2006 and
May 2007. The outbreak involved approximately 10% of the patients with CVCs who were receiving home-based chemotherapy, and
it represents the second larger outbreak of CVCs-associated BSIs due to Klebsiella oxytoca in oncology outpatient centers. We retrospectively analyzed the chain of investigations and prophylactic/diagnostic measures
taken to eradicate the infection: (1) patients’ chart audit, (2) estimation of the infection among asymptomatic patients,
(3) implementation of the level of awareness of medical and paramedical personnel, (4) collection of samples from environment,
medications and infusion materials, (5) critical appraisal of chemotherapeutical schemes and (6) cooperation with peripheral
institutions. The isolation of Klebsiella oxytoca in a chemotherapy solution (infusional 5-FU in dextrose 5% solution within a 48 h pump) from a peripheral General Hospital
and the prompt transmission of the data to the chemotherapy center played a key role for the management of the infection cluster.
This is the first report that evidenced the detection of Klebsiella oxytoca within a chemotherapeutical preparation. Data transmission from peripheral hospitals to the central institution resulted
in an important feedback that allowed a better estimation of the infection cluster and more tailored actions for the eradication
of the infection. 相似文献
994.
Armakolas A Panteleakou Z Nezos A Tsouma A Skondra M Lembessis P Pissimissis N Koutsilieris M 《Future oncology (London, England)》2010,6(12):1849-1856
As the presence of tumor cells circulating in the blood is associated with systemic disease and shortened survival, the establishment of a method to detect circulating tumor cells (CTCs) is of critical importance for a more concise staging and follow-up of cancer patients. Recently, the most robust strategies for the determination of CTCs are the PCR-based methods and the CellSearch? system that exploits the immunofluorescent characterization and isolation of cancer cells. Herein, we analyzed the experimental strategies used for determining CTCs with respect to accuracy, sensitivity and reproducibility in cancers of the breast, colon, prostate and melanoma. 相似文献
995.
Markos Minas Nikolaos Koukosias Elias Zintzaras Konstantinos Kostikas Konstantinos I Gourgoulianis 《BMC health services research》2010,10(1):252
Background
In Greece there is lack of large epidemiological studies regarding morbidity and mortality in primary health care. The aim of the present study was to estimate the prevalence and morbidity of the most common diseases in a large population sample from primary health care. 相似文献996.
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Burbos N Musonda P Crocker SG Morris EP Duncan TJ Nieto JJ 《Gynecologic oncology》2012,125(1):120-123
Objective
The objective of this study is to determine the incidence of endometrial cancer in young postmenopausal women presenting with vaginal bleeding.Methods
Cross-sectional study of postmenopausal women presenting with vaginal bleeding in a gynaecological oncology centre in the United Kingdom. All women underwent transvaginal ultrasound scanning (TVS) as the initial investigation tool to evaluate the endometrium. Endometrial biopsy was performed only in cases where endometrial thickness measured equal to or greater than 5 mm. The patients were divided into two groups based on their age: less than 50 years (Group A) and 50 years or older (Group B).Results
Over a 57-month period, 4454 women were investigated for postmenopausal vaginal bleeding. Of these, 259 (5.8%) women were diagnosed with endometrial carcinoma. 260 (5.8%) women were younger than 50 years. Endometrial biopsy was not performed in 130 women in Group A that had an endometrial thickness measurement of less than 5 mm on ultrasonography. With a median follow-up period of 3 (1-5) years, we found no cases of endometrial cancer in women under the age of 50 that did not undergo endometrial biopsy at the time of initial evaluation. Overall, no cases of endometrial cancer were diagnosed in postmenopausal women under the age of 50 years.Conclusions
We found no cases of endometrial cancer amongst 260 women presenting with postmenopausal vaginal bleeding under the age of 50 years. These women could be investigated on a less urgent basis depending on the available resources. 相似文献999.
Chalvatzis NT Kalantzis G Manthou ME Collins C Potts MJ 《Ophthalmic plastic and reconstructive surgery》2008,24(3):229-231
A 60-year-old woman was referred to Bristol Eye Hospital because of a progressive, painless, right proptosis. CT revealed a well-defined, hyperdense lesion adjacent to the lateral orbital wall. A marginal excision was performed. The mass was stony-hard, lobulated, and encapsulated. Histopathologic findings were consistent with a low-grade parosteal osteosarcoma. Parosteal osteosarcoma is a rare osteogenic tumor that usually affects the long bones. It represents a malignant, though well differentiated, tumor that has a relatively good prognosis after a wide excision. However, local recurrences are not rare and have been associated with dedifferentiation. The latter affects the prognosis adversely and, thus, regular follow-ups are strongly suggested after the initial tumor excision. In the present case, no further treatment was administered and the patient was reported disease free 26 months after surgery. 相似文献
1000.