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991.
Rachel H Mulholland Rachael Wood Helen R Stagg Colin Fischbacher Jaime Villacampa Colin R Simpson Eleftheria Vasileiou Colin McCowan Sarah J Stock Annemarie B Docherty Lewis D Ritchie Utkarsh Agrawal Chris Robertson Josephine LK Murray Fiona MacKenzie Aziz Sheikh 《Journal of the Royal Society of Medicine》2020,113(11):444
992.
993.
Marx Sascha Tsavdaridou Ioanna Paul Sebastian Steveling Antje Schirmer Cornelia Eördögh Marton Nowak Stephan Matthes Marc El Refaee Ehab Fleck Steffen K. Baldauf Joerg Lerch Markus M. Stahl Andreas Hosemann Werner Schroeder Henry W. S. 《Neurosurgical review》2021,44(3):1569-1582
Neurosurgical Review - The endoscopic endonasal approach to suprasellar craniopharyngiomas has become popular as alternative to transcranial approaches. However, the literature lacks data regarding... 相似文献
994.
Maria Kafyra Ioanna Panagiota Kalafati Satish Kumar Maria Spyridoula Kontoe Christine Masson Sophie Siest George V. Dedoussis 《Nutrients》2021,13(1)
The present study sought to retrospectively investigate the dietary habits of two adolescent, European populations from the cross-sectional Greek TEENAGE Study and French STANISLAS Family Study. We aimed to explore the relation between the populations’ dietary patterns and blood pressure, glycemic and lipidemic profile. Dietary patterns were extracted via Principal Component Analysis (PCA), based on data collected from two 24 h dietary recalls for the TEENAGE study and a 3-day food consumption diary for the STANISLAS study. Multiple linear regressions and mixed models analyses, adjusting for confounding factors, were employed to investigate potential associations. A total of 766 Greek teenagers and 287 French teenagers, were included in analyses. Five dietary patterns were extracted for each population accounting for 49.35% and 46.69% of their respective total variance, with similarities regarding the consumption of specific food groups (i.e., western-type foods). In the TEENAGE Study, the “chicken and sugars” pattern was associated with lower CRP levels, after adjusting for confounding factors (p-value < 0.01). The “high protein and animal fat” dietary pattern of the STANISLAS Family Study was related to higher BMI (p-value < 0.01) and higher triglycerides levels (p-value < 0.01). Our findings summarize the dietary habits of two teenage, European populations and their associations with cardiometabolic risk factors. 相似文献
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997.
Hendrik Manner Andrea May Ioanna Kouti Oliver Pech Michael Vieth Christian Ell 《Surgical endoscopy》2016,30(4):1364-1370
Background and study aim
After thermal ablation of Barrett’s esophagus (BE), stricture formation is reported in 5 to over 10 % of patients. The question arises whether submucosal fluid injection prior to ablation may lower the risk of stricture formation. The aim of the present study was to evaluate the efficacy and safety of the new technique of Hybrid-APC which combines submucosal injection with APC.Patients and methods
Patients who had a residual BE segment of at least 1 cm after endoscopic resection of early Barrett’s neoplasia underwent thermal ablation of BE by Hybrid-APC. Prior to thermal ablation, submucosal injection of sodium chloride 0.9 % was carried out using a flexible water-jet probe (Erbejet 2; Erbe Elektromedizin, Tuebingen, Germany). Check-up upper GI endoscopy was carried out 3 months after macroscopically complete ablation including biopsies from the neo-Z-line and the former BE segment, and recording of stricture formation.Results
From May 2011 to November 2012, a total of 60 patients (pt) were included in the study [55 pt male (92 %); mean age 62 ± 9 years, range 42–79]. Ten patients were excluded from the study. In the remaining 50 pt, Hybrid-APC ablation and check-up endoscopy at 3 months were carried out. Forty-eight out of 50 pt (96 %; ITT: 49/60, 82 %) achieved macroscopically complete remission after a median of 3.5 APC sessions [SD 2.4; range 1–10]. Freedom from BE was histopathologically observed in 39/50 patients (78 %). There was one treatment-related stricture (2 %). Minor adverse events of Hybrid-APC were observed in 11 patients (22 %).Conclusions
According to this pilot series, Hybrid-APC was effective and safe for BE ablation in a tertiary referral center. The rate of stricture formation was only 2 %. Further studies are required to confirm the present results.German Clinical Trials Register
DRKS00003369.998.
Maria K. Angelopoulou Theodoros P. Vassilakopoulos Ioannis Batsis Ioanna Sakellari Konstantinos Gkirkas Vasiliki Pappa Panagiota Giannoulia Ioannis Apostolidis Christos Apostolopoulos Paraskevi Roussou Panayiotis Panayiotidis Maria Dimou Marie‐Christine Kyrtsonis Maria Palassopoulou Georgios Vassilopoulos Maria Moschogiannis Christina Kalpadakis Dimitrios Margaritis Alexander Spyridonidis Eurydiki Michalis Konstantinos Anargyrou Panagiotis Repousis Eleutheria Hatzimichael Zoi Bousiou Elias Poulakidas Dimitrios Grentzelias Nikolaos Harhalakis Gerassimos A. Pangalis Achilles Anagnostopoulos Panagiotis Tsirigotis 《Hematological oncology》2018,36(1):174-181
This retrospective study aimed to describe the Hellenic experience on the use of brentuximab vedotin (BV) in relapsed/refractory (R/R) Hodgkin lymphoma (HL) given within its indication. From June 2011 to April 2015, ninety‐five patients with R/R HL, who received BV in 20 centers from Greece, were analyzed. Their median age was 33 years, and 62% were males. Sixty‐seven patients received BV after autologous stem cell transplantation failure, whereas 28 patients were treated with BV without a prior autologous stem cell transplantation, due to advanced age/comorbidities or chemorefractory disease. The median number of prior treatments was 4 and 44% of the patients were refractory to their most recent therapy. The median number of BV cycles was 8 (range, 2‐16), and the median time to best response was the fourth cycle. Fifty‐seven patients achieved an objective response: twenty‐two (23%), a complete response (CR), and 35 patients (37%), a partial, for an overall response rate of 60%. Twelve patients (13%) had stable disease, and the remaining twenty‐six (27%) had progressive disease as their best response. At a median follow‐up of 11.5 months, median progression‐free survival and overall survival were 8 and 26.5 months, respectively. Multivariate analysis showed that chemosensitivity to treatment administered before BV was associated with a significantly increased probability of achieving response to BV (P = .005). Bulky disease (P = .01) and response to BV (P <.001) were significant for progression‐free survival, while refractoriness to most recent treatment (P = .04), bulky disease (P = .005), and B‐symptoms (P = .001) were unfavorable factors for overall survival. Among the 22 CRs, 5 remain in CR with no further treatment after BV at a median follow‐up of 13 months. In conclusion, our data indicate that BV is an effective treatment for R/R HL patients even outside clinical trials. Whether BV can cure a fraction of patients remains to be seen. 相似文献
999.
Ioanna Athanasiadou Ariadni Vonaparti Aristeidis Dokoumetzidis Amal Saleh Miriam Mbeloug Mohammed Al‐Maadheed Georgia Valsami Costas Georgakopoulos 《Scandinavian journal of medicine & science in sports》2019,29(10):1489-1500
The aim of the present study was to investigate if hyperhydration could influence the excretion and subsequent detection of budesonide (BDS) and its main metabolites (6β‐hydroxy‐budesonide and 16α‐hydroxy‐prednisolone) during doping control analysis by leading to concentrations below the WADA reporting level (30 ng/mL). The influence of hyperhydration on the plasma and urinary pharmacokinetic (PK) profiles of BDS and metabolites was also examined. Seven healthy physically active non‐smoking Caucasian males participated in a 15‐day clinical study. BDS was administered orally at a single dose of 9 mg on Days 1, 7, and 13. Hyperhydration was applied in the morning on two consecutive days, that is, 0 and 24 hours after first fluid ingestion. Water and a commercial sports drink were used as hyperhydration agents (20 mL/kg body weight). Results showed no significant difference (P > 0.05, 95% CI) on plasma or urinary PK parameters under hyperhydration conditions for all the analytes. However, significant differences (P < 0.05, 95% CI) due to hyperhydration were observed on the urinary concentrations of BDS and metabolites. To compensate the dilution effect due to hyperhydration, different adjustment methods were applied based on specific gravity, urinary flow rate, and creatinine. All the applied methods were able to adjust the concentration values close to the baseline ones for each analyte; however, specific gravity was the optimum method in terms of effectiveness and practicability. Furthermore, no masking of the detection sensitivity of BDS or its metabolites was observed due to hyperhydration either in plasma or urine samples. 相似文献
1000.
Literature review of visual representation of the results of benefit–risk assessments of medicinal products
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Christine E. Hallgreen Shahrul Mt‐Isa Alfons Lieftucht Lawrence D. Phillips Diana Hughes Susan Talbot Alex Asiimwe Gerald Downey Georgy Genov Richard Hermann Rebecca Noel Ruth Peters Alain Micaleff Ioanna Tzoulaki Deborah Ashby On behalf of PROTECT Benefit–Risk group 《Pharmacoepidemiology and drug safety》2016,25(3):238-250