全文获取类型
收费全文 | 1277篇 |
免费 | 113篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 24篇 |
妇产科学 | 41篇 |
基础医学 | 163篇 |
口腔科学 | 103篇 |
临床医学 | 111篇 |
内科学 | 294篇 |
皮肤病学 | 35篇 |
神经病学 | 87篇 |
特种医学 | 24篇 |
外科学 | 120篇 |
综合类 | 29篇 |
一般理论 | 1篇 |
预防医学 | 86篇 |
眼科学 | 41篇 |
药学 | 109篇 |
中国医学 | 18篇 |
肿瘤学 | 92篇 |
出版年
2024年 | 1篇 |
2023年 | 27篇 |
2022年 | 30篇 |
2021年 | 111篇 |
2020年 | 63篇 |
2019年 | 102篇 |
2018年 | 83篇 |
2017年 | 76篇 |
2016年 | 76篇 |
2015年 | 62篇 |
2014年 | 80篇 |
2013年 | 104篇 |
2012年 | 119篇 |
2011年 | 88篇 |
2010年 | 42篇 |
2009年 | 31篇 |
2008年 | 62篇 |
2007年 | 63篇 |
2006年 | 45篇 |
2005年 | 34篇 |
2004年 | 28篇 |
2003年 | 23篇 |
2002年 | 21篇 |
2001年 | 7篇 |
2000年 | 4篇 |
1999年 | 6篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1989年 | 1篇 |
1987年 | 1篇 |
排序方式: 共有1397条查询结果,搜索用时 458 毫秒
41.
42.
43.
Yu Nee Lee Francesco Frugoni Kerry Dobbs Jolan E. Walter Silvia Giliani Andrew R. Gennery Waleed Al-Herz Elie Haddad Francoise LeDeist Jack H. Bleesing Lauren A. Henderson Sung-Yun Pai Robert P. Nelson Dalia H. El-Ghoneimy Reem A. El-Feky Shereen M. Reda Elham Hossny Pere Soler-Palacin Ramsay L. Fuleihan Niraj C. Patel Michel J. Massaad Raif S. Geha Jennifer M. Puck Paolo Palma Caterina Cancrini Karin Chen Mauno Vihinen Frederick W. Alt Luigi D. Notarangelo 《The Journal of allergy and clinical immunology》2014
44.
Mohammad Saeid Rezaee Zavareh Seyed Moayed Alavian Hamidreza Karimisari Mostafa Shafiei Seyed Yasser Saiedi Hosseini 《Hepatitis monthly》2014,14(8)
Background:
Occult hepatitis C virus infection (OCI) is recognized by finding hepatitis C virus (HCV) RNA in hepatocytes without detectable anti-HCV antibodies and viral RNA in plasma. Autoimmune hepatitis (AIH) is a chronic and generally progressive disease without exactly-identified etiology.Objectives:
This study aimed to determine the prevalence of OCI among patients with AIH and to evaluate the tests used to rule out HCV infection in diagnosing AIH.Patients and Methods:
Between July 2012 to February 2013, 35 Iranian patients with AIH who attended Tehran Hepatitis Center were investigated. For identifying OCI, detection of HCV RNA in both ultracentrifuged serum samples and peripheral blood mononuclear cells (PBMCs) was used. Data analysis was performed using SPSS.Results:
Six males and 29 females with mean disease duration of 77.1 ± 39.5 month and mean age of 43.62 ± 12.67 years were investigated. All cases were negative for anti-HCV antibody and we could not find any HCV RNA in ultracentrifuged serum samples and PBMCs.Conclusions:
With our laboratory diagnostic method, it seems that there are no cases of OCI in patients with AIH. However, we recommend further studies with more samples and more precise laboratory method. 相似文献45.
Ahmad Reza Movassaghi Gholamreza Mohammadi Massoud Rezaee Oghazi 《Comparative clinical pathology》2013,22(3):535-537
A 3-year-old female Holstein cow was referred for necropsy examination with the history of inappetence, progressive indigestion, distension of the rumen and death. At necropsy examination, a lobulated grey-white mass (12?×?8?×?5 cm) was found close to the reticulo-omasal orifice. On sectioning, the tumour mass was gelatinous with intervening fibrous septa. Microscopical examination revealed unencapsulated mass composed of various cellular parts and matrices. There were proliferated spindle shaped fibrocytes producing repetitive collagenous fibres. There were also foci of low cellularity containing stellate cells with small and hyperchromatic nuclei arranged in a mucinous ground substance. On the basis of the gross and histopathological findings and histochemical stainings, the tumour was diagnosed as a fibromyxoma. This tumour has not been recorded previously in the reticulo-omasal orifice of a cow. 相似文献
46.
47.
Saeed Rayati Elham Khodaei Parinaz Nafarieh Majid Jafarian Bahareh Elmi Andrzej Wojtczak 《RSC advances》2020,10(29):17026
In this study, a novel Mn(iii)–Schiff base complex was synthesized and characterized. The structure of this complex was determined to be a deformed octahedral coordination sphere by single-crystal X-ray diffraction analysis. The Mn(iii)–Schiff base complex was supported on silica-coated iron magnetic nanoparticles via axial coordination by one-step complex anchoring to produce a heterogenized nanocatalyst. After this, the complex was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM), and powder X-ray diffraction (XRD). Moreover, atomic absorption spectroscopy was used to determine the amount of the loaded metal. The heterogenized nanocatalyst effectively catalyzed the oxidation of a broad range of sulfides and alkenes with H2O2 in the presence of a glassy carbon electrode, applying voltage to the reaction mixture. The results showed that the application of a potential to the reaction mixture could significantly decrease the reaction time when compared with the case of similar chemical oxidation reactions. In addition, an excellent value of turnover frequency (17 750 h−1) was achieved for the electrochemical oxidation of styrene. Moreover, the nanocatalyst showed good recoverability without significant loss of its activity within six successive runs in the electrochemical oxidation of methyl phenyl sulfide and cyclooctene. The electrochemical properties and stability of Fe3O4@SiO2-[MnL(OAc)] were investigated by cyclic voltammetry measurements and chronoamperometry technique.A Mn–Schiff base complex supported on silica-coated iron magnetic nanoparticles was used for the electrochemical oxidation of sulfides and alkenes. 相似文献
48.
Direct C–H bond oxidation of organic materials, and producing the necessary oxygenated compounds under mild conditions, has attracted increasing interest. The selective oxidation of various alkylbenzenes was carried out by means of a new catalyst containing VO2+ species supported on silica-coated Fe3O4 nanoparticles using t-butyl hydroperoxide as an oxidant at room temperature in H2O or solvent-free media. The chemical and structural characterization of the catalyst using several methods such as FTIR spectroscopy, XRD, FETEM, FESEM, SAED, EDX and XPS showed that VO2+ is covalently bonded to the silica surface. High selectivity and excellent conversion of various toluene derivatives, with less reactive aliphatic (sp3) C–H bonds, to related benzoic acids were quite noticeable. The aerobic oxygenation reaction of these alkylbenzenes was studied under the same conditions. All the results accompanied by sustainability of the inexpensive and simple magnetically separable heterogeneous catalyst proved the important criteria for commercial applications.A highly efficient, recoverable, sustainable, economic and eco-friendly catalyst containing VO2+ species supported on SiO2@Fe3O4 nanoparticles for selective oxidation of alkylbenzenes using TBHP or O2 at room temperature in H2O or solvent-free media. 相似文献
49.
50.
Iman Mahlooji Maryam Shokri Rana Manoochehri Mohammad Mahboubi-Rabbani Elham Rezaee Sayyed Abbas Tabatabai 《Archiv der Pharmazie》2020,353(8):2000052
Soluble epoxide hydrolase (sEH) inhibitors are effective in reducing blood pressure, inflammation, and pain in a number of mammalian disease models. As most classical urea-based sEH inhibitors suffer from poor solubility and pharmacokinetic properties, the development of novel sEH inhibitors with an improved pharmacokinetic specification has received a great deal of attention. In this study, a series of amide-based sEH inhibitors bearing a phthalimide ring as the novel secondary pharmacophore (P2) was designed, synthesized, and evaluated. Docking results illustrated that the amide group as the primary pharmacophore (P1) was placed at a suitable distance from the three key amino acids (Tyr383, Tyr466, and Asp335) for an effective hydrogen bonding. In agreement with these findings, most of the newly synthesized compounds demonstrated moderate to high sEH inhibitory activities, relative to 12-(3-adamantan-1-yl-ureido)dodecanoic acid as the reference standard. Compound 12e with a 4-methoxybenzoyl substituent exhibited the highest sEH inhibitory activity, with an IC50 value of 1.06 nM. Moreover, the ADME properties of the compounds were evaluated in silico, and the results revealed appropriate predictions. 相似文献