全文获取类型
收费全文 | 1615篇 |
免费 | 121篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 60篇 |
妇产科学 | 48篇 |
基础医学 | 248篇 |
口腔科学 | 52篇 |
临床医学 | 188篇 |
内科学 | 237篇 |
皮肤病学 | 43篇 |
神经病学 | 129篇 |
特种医学 | 15篇 |
外科学 | 150篇 |
综合类 | 9篇 |
一般理论 | 2篇 |
预防医学 | 292篇 |
眼科学 | 12篇 |
药学 | 94篇 |
中国医学 | 7篇 |
肿瘤学 | 142篇 |
出版年
2023年 | 14篇 |
2022年 | 11篇 |
2021年 | 53篇 |
2020年 | 35篇 |
2019年 | 48篇 |
2018年 | 63篇 |
2017年 | 48篇 |
2016年 | 50篇 |
2015年 | 57篇 |
2014年 | 58篇 |
2013年 | 100篇 |
2012年 | 138篇 |
2011年 | 117篇 |
2010年 | 90篇 |
2009年 | 46篇 |
2008年 | 106篇 |
2007年 | 111篇 |
2006年 | 89篇 |
2005年 | 103篇 |
2004年 | 102篇 |
2003年 | 78篇 |
2002年 | 73篇 |
2001年 | 10篇 |
2000年 | 8篇 |
1999年 | 12篇 |
1998年 | 9篇 |
1997年 | 19篇 |
1996年 | 11篇 |
1995年 | 9篇 |
1994年 | 9篇 |
1993年 | 3篇 |
1992年 | 9篇 |
1991年 | 10篇 |
1990年 | 5篇 |
1989年 | 2篇 |
1988年 | 3篇 |
1987年 | 1篇 |
1986年 | 3篇 |
1985年 | 4篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1982年 | 1篇 |
1981年 | 5篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1976年 | 1篇 |
1975年 | 2篇 |
1967年 | 1篇 |
1966年 | 1篇 |
1940年 | 1篇 |
排序方式: 共有1740条查询结果,搜索用时 31 毫秒
41.
Andrew M. Zeiger Meghan E. McGarry Angel C. Y. Mak Vivian Medina Sandra Salazar Celeste Eng Amy K. Liu Sam S. Oh Thomas J. Nuckton Deepti Jain Thomas W. Blackwell Hyun Min Kang Goncalo Abecasis Leandra Cordero Oate Max A. Seibold Esteban G. Burchard Jose Rodriguez‐Santana 《Pediatric pulmonology》2020,55(2):533-540
42.
Jonathan J. Lyons Guangping Sun Kelly D. Stone Celeste Nelson Laura Wisch Michelle O'Brien Nina Jones Andrew Lindsley Hirsh D. Komarow Yun Bai Linda M. Scott Daly Cantave Irina Maric J. Pablo Abonia Marc E. Rothenberg Lawrence B. Schwartz Joshua D. Milner Todd M. Wilson 《The Journal of allergy and clinical immunology》2014
43.
Christian P Vink Charlotte W Ockeloen Sietske ten Kate David A Koolen Johannes Kristian Ploos van Amstel Anne-Marie Kuijpers-Jagtman Celeste C van Heumen Tjitske Kleefstra Carine E L Carels 《European journal of human genetics : EJHG》2014,22(9):1063-1070
This article describes the inter- and intra-familial phenotypic variability in four families with WNT10A mutations. Clinical characteristics of the patients range from mild to severe isolated tooth agenesis, over mild symptoms of ectodermal dysplasia, to more severe syndromic forms like odonto-onycho-dermal dysplasia (OODD) and Schöpf–Schulz–Passarge syndrome (SSPS). Recurrent WNT10A mutations were identified in all affected family members and the associated symptoms are presented with emphasis on the dentofacial phenotypes obtained with inter alia three-dimensional facial stereophotogrammetry. A comprehensive overview of the literature regarding WNT10A mutations, associated conditions and developmental defects is presented. We conclude that OODD and SSPS should be considered as variable expressions of the same WNT10A genotype. In all affected individuals, a dished-in facial appearance was observed which might be helpful in the clinical setting as a clue to the underlying genetic etiology. 相似文献
44.
Lijoy K. Mathew Nicolas Skuli Vera Mucaj Samuel S. Lee Pascal O. Zinn Pratheesh Sathyan Hongxia Z. Imtiyaz Zhongfa Zhang Ramana V. Davuluri Shilpa Rao Sriram Venneti Priti Lal Justin D. Lathia Jeremy N. Rich Brian Keith Andy J. Minn M. Celeste Simon 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(1):291-296
45.
Beatriz Julieta Celeste Maria Carmen Arroyo Sanchez Eduardo Milton Ramos-Sanchez Luiz Guilherme M. Castro Francisco Assis Lima Costa Hiro Goto 《The American journal of tropical medicine and hygiene》2014,90(5):860-865
Routine serological diagnoses for leishmaniases, except in visceral cases, are performed using whole-parasite antigens. We used enzyme-linked immunosorbent assay (ELISA) to evaluate the performance of Leishmania infantum rHsp83 compared with L. major-like total promastigote antigen in the diagnosis of cutaneous (CL), mucosal (ML), and visceral leishmaniases (VL). ELISA-rHsp83 was significantly more sensitive than ELISA–L. major-like when considering either CL/ML (P = 0.041) or all leishmaniasis patients (P = 0.013). When samples from other infectious disease patients were evaluated for cross-reactivity, ELISA-rHsp83 was more specific than ELISA–L. major-like, specifically for Chagas disease samples (P < 0.001). We also evaluated the anti-rHsp83 antibody titers months after treatment and observed no significant difference in ML (P = 0.607) or CL (P = 0.205). We recommend ELISA–L. infantum-rHsp83 as a routine confirmatory serological assay for the diagnosis of Leishmania infection because of the high sensitivity, the specificity, and the insignificant cross-reactivity with other infectious diseases. 相似文献
46.
47.
48.
Millimono TS Loua KM Rath SL Relvas L Bento C Diakite M Jarvis M Daries N Ribeiro LM Manco L Kaeda JS 《Hemoglobin》2012,36(1):25-37
Reliable and accurate epidemiological data is a prerequisite for a cost effective screening program for inherited disorders, which however, is lacking in a number of developing countries. Here we report the first detailed population study in the Republic of Guinea, a sub-Saharan West African country, designed to assess the frequency of glucose-6-phosphate dehydrogenase (G6PD) deficiency and hemoglobinopathies, including screening for thalassemia. Peripheral blood samples from 187 Guinean adults were screened for hemoglobin (Hb) variants by standard hematological methods. One hundred and ten samples from males were screened for G6PD deficiency by the fluorescent spot test. Molecular analysis was performed for the most common α-thalassemia (α-thal) deletions, β-globin gene mutations, G6PD variants B (376A), A (376G), A- (376G/202A) and Betica (376G/968C), using polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP) or sequencing. Of the 187 subjects screened, 36 were heterozygous for Hb S [β6(A3)Glu→Val, GAG>GTG] (allele frequency 9.62%). Sixty-four subjects were heterozygous and seven were homozygous for the -α(3.7) kb deletion (allele frequency 20.85%). β-Thalassemia alleles were detected in five subjects, four with the -29 (A>G) mutation (allele frequency 1.07%) and one with codon 15 (TGG>TAG) (allele frequency 0.96%). The G6PD A- and G6PD Betica deficient variants were highly prevalent with a frequency of 5.7 and 3.3%, respectively. While we did not test for ferritin levels or α(0)-thal, four females (5.2%) had red cell indices strongly suggestive of iron deficient anemia: Hb <9.7 g/dL; MCH <19.3 pg; MCV <68.2; MCHC <31.6 g/dl; RDW >19.8%. Our results are consistent with high frequency of alleles such as Hb S, α-thal and G6PD deficient alleles associated with malaria resistance. Finding a 9.6% Hb S allele frequency supports the notion for a proficient neonatal screening to identify the sickle cell patients, who might benefit from early prophylactic treatment for infections. The incidence of significant iron deficient anemia in women is lower than expected in an under developed country. 相似文献
49.