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排序方式: 共有2141条查询结果,搜索用时 443 毫秒
71.
Akira Kawamura Ilyas Washington Doina M. Mihai Francesca Bartolini Gregg G. Gundersen Milica Tesic Mark Koji Nakanishi 《Chemical biology & drug design》2017,89(4):475-481
Ginkgolides are terpene trilactones in Ginkgo biloba, a popular medicinal herb for memory disorders. Although ginkgolides are known for various neurobiological effects, their macromolecular target in brain is unknown. In this work, we employed benzophenone derivatives of ginkgolides to identify their binding target in brain. Photolabeling of bovine hippocampus homogenates identified a series of α‐tubulin isotypes. Selective photolabeling of α‐tubulin over β‐tubulin, which is equally abundant in brain, suggested that ginkgolides might modulate microtubule biology differently than typical microtubule‐binding agents, such as taxol. In fact, ginkgolide A did not affect microtubule polymerization or cell proliferation; instead, it inhibited detyrosination of α‐tubulin and reorientation of microtubule‐organizing centers. Taken together, the current findings indicate that ginkgolides constitute a new class of microtubule‐binding agents with distinct effects on α‐tubulin biology. 相似文献
72.
4D flow MRI can detect subtle right ventricular dysfunction in primary left ventricular disease
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![点击此处可从《Journal of magnetic resonance imaging : JMRI》网站下载免费的PDF全文](/ch/ext_images/free.gif)
73.
74.
Smoking cessation is associated with improved survival in oropharynx cancer treated by chemoradiation
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![点击此处可从《The Laryngoscope》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Alexis J. Platek BSc Vijayvel Jayaprakash MBBS PhD Mihai Merzianu MD Mary E. Platek PhD David M. Cohan MD Wesley L. Hicks MD Jr. Sathiya P. Marimuthu MBBS Timothy B. Winslow MS Vishal Gupta MD Hassan Arshad MD Moni A. Kuriakose MD Shiva Dibaj MS James R. Marshall PhD Mary E. Reid PhD Graham W. Warren MD PhD Anurag K. Singh MD 《The Laryngoscope》2016,126(12):2733-2738
75.
Long‐term results of a prospective randomized trial assessing the impact of re‐adaptation of the dorsolateral peritoneal layer after extended pelvic lymph node dissection and cystectomy
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![点击此处可从《BJU international》网站下载免费的PDF全文](/ch/ext_images/free.gif)
76.
Photodynamic therapy with 3‐(1′‐hexyloxyethyl) pyropheophorbide‐a for early‐stage cancer of the larynx: Phase Ib study
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![点击此处可从《Head & neck》网站下载免费的PDF全文](/ch/ext_images/free.gif)
77.
Solomon LW Merzianu M Sullivan M Rigual NR 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2007,103(2):e39-e42
Necrotizing sialometaplasia (NSM) is a self-limiting disorder affecting mainly the minor salivary glands. The significance of NSM resides in its clinical and histopathological resemblance to carcinoma. Few cases of NSM associated with eating disorders have been reported to date. We present here the clinical features and histomorphology of an additional case of bulimia-associated NSM closely mimicking an invasive carcinoma. A high index of suspicion and good communication between clinician and pathologist are essential in recognizing this entity and preventing unnecessary surgical therapy. 相似文献
78.
Jordi Ochando Zahi A. Fayad Joren C. Madsen Mihai G. Netea Willem J. M. Mulder 《American journal of transplantation》2020,20(1):10-18
Consistent induction of donor‐specific unresponsiveness in the absence of continuous immunosuppressive therapy and toxic effects remains a difficult task in clinical organ transplantation. Transplant immunologists have developed numerous experimental treatments that target antigen‐presentation (signal 1), costimulation (signal 2), and cytokine production (signal 3) to establish transplantation tolerance. While promising results have been obtained using therapeutic approaches that predominantly target the adaptive immune response, the long‐term graft survival rates remain suboptimal. This suggests the existence of unrecognized allograft rejection mechanisms that contribute to organ failure. We postulate that trained immunity stimulatory pathways are critical to the immune response that mediates graft loss. Trained immunity is a recently discovered functional program of the innate immune system, which is characterized by nonpermanent epigenetic and metabolic reprogramming of macrophages. Since trained macrophages upregulate costimulatory molecules (signal 2) and produce pro‐inflammatory cytokines (signal 3), they contribute to potent graft reactive immune responses and organ transplant rejection. In this review, we summarize the detrimental effects of trained immunity in the context of organ transplantation and describe pathways that induce macrophage training associated with graft rejection. 相似文献
79.
Short‐term splenic impact of single‐strand DNA functionalized multi‐walled carbon nanotubes intraperitoneally injected in rats
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![点击此处可从《Journal of applied toxicology : JAT》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Simona Clichici Alexandru Radu Biris Cornel Catoi Adriana Filip Flaviu Tabaran 《Journal of applied toxicology : JAT》2014,34(4):332-344
In recent years, a great deal of studies have focused on the possible toxicity of carbon nanotubes (CNT), as a result of their potential applications in the field of nanotechnologies. The investigation of spleen toxicity is part of the carbon nanotubes‐induced toxicity assessment. In this study, we investigated the possible toxic effects of CNT on the rat spleen, after intraperitoneally (i.p.) administration of a single dose [1.5 ml; 2 mg multi‐walled (MW) CNT per body weight (bw)] of multi‐walled carbon nanotubes (exterior diameter 15–25 nm, interior diameter 10–15 nm, surface 88 m2 g–1) functionalized 1:1 with single‐strand DNA (ss‐DNA‐MWCNT, 270 mg l–1). CNT functionalization with DNA determines a stable dispersion in the body fluids. For the detection of carbon nanotubes in the spleen, Raman spectroscopy, histopathologic examination, confocal microscopy and transmission electron microscopy (TEM) were performed at different time points (1, 6, 24, 48 and 144 h) after MWCNT administration. The dynamics of oxidative stress parameters (malondialdehyde, protein carbonyls and reduced glutathione), along with nitrosative stress parameters (nitric oxide, inducible NO synthase), the pro‐inflammatory cytokines [interleukin‐(IL)‐1β] and the number of cells expressing caspase 3 and proliferating cell nuclear antigen (PCNA) were assessed. Our results indicate that, after i.p. administration, MWCNT translocate progressively in the spleen, with a peak of concentration after 48 h, and determine lymphoid hyperplasia and an increase in the number of cells which undergo apoptosis, in parallel with the enhancement of the mitosis in the white pulp and with transient alterations of oxidative stress and inflammation that need further investigations for a longer period of monitoring. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
80.
Alexandru Mihai Grumezescu Cristina Daniela Ghitulica Georgeta Voicu Keng-Shiang Huang Chih-Hui Yang Anton Ficai Bogdan Stefan Vasile Valentina Grumezescu Coralia Bleotu Mariana Carmen Chifiriuc 《International journal of pharmaceutics》2014
In this paper, we report the synthesis, characterization (FT-IR, XRD, BET, HR-TEM) and bioevaluation of a novel γ-aminobutiric acid/silica (noted GABA-SiO2 or γ-SiO2) hybrid nanostructure, for the improved release of topical antibiotics, used in the treatment of Staphylococcus aureus infections. GABA-SiO2 showed IR bands which were assigned to Si–O–Si (stretch mode). The XRD pattern showed a broad peak in the range of 18–30° (2θ), indicating an amorphous structure. Based on the BET analysis, estimations about surface area (438.14 m2/g) and pore diameters (4.76 nm) were done. TEM observation reveals that the prepared structure presented homogeneity and an average size of particles not exceeding 10 nm. The prepared nanostructure has significantly improved the anti-staphylococcal activity of bacitracin and kanamycin sulfate, as demonstrated by the drastic decrease of the minimal inhibitory concentration of the respective antibiotics loaded in the GABA-SiO2 nanostructure. These results, correlated with the high biocompatibility of this porous structure, are highlighting the possibility of using this carrier for the local delivery of the antimicrobial substances in lower active doses, thus reducing their cytotoxicity and side-effects. 相似文献