尼群地平对体外循环中血小板数量及粘附,聚集功能的影响

４０例先天性心脏病患儿按随机配对原则分为对照组（Ｃ组）与实验组（Ｎ组）。Ｎ组术前７ｄ口服尼群地平０．５ｍｇ·ｋｇ－１／次，１次／８ｈ，最后１次用药于术前２ｈ。测定围体外循环期血小板计数、瑞斯托霉素及ＡＤＰ诱导的最大凝集率。结果表明，Ｎ组血小板计数、瑞斯托霉素诱导的最大凝集率在转流中、后增高于Ｃ组（Ｐ＜０．０５～０．０１），ＡＤＰ诱导的最大聚集率在转流前、中低于Ｃ组，转流后高于Ｃ组（Ｐ＜０．０５～０．０１），术后纵隔引流量明显减少。说明尼群地平能有效地抑制体外循环中血小板活化，保护血小板的数量与功能     

不妨向猫学习

当小猫决定“现在是放松的时候”,没有任何东西、没有任何人可以夺走它的休息时光。所以猫的主人经常羡慕不已地叹息道:“哎,要是我也能这样放松那该多好啊！     

干扰素与利巴韦林治疗乙型肝炎对姐妹染色单体交换率的影响

作者对干扰素与利巴韦林（病毒唑）联合治疗乙型肝炎的姐妹染色单体交换率（ＳＣＥ）的影响进行了体外试验和临床研究。体外试验结果，与临床用药前的ＳＣＥ比较有明显差异（Ｐ＜０．０５，＜０．０１）而与对照无差异（Ｐ＞０．０５），临床用药后的ＳＣＥ恢复正常，一年随访无变化。从细胞遗传效应角度提示干扰素与利巴韦林治疗乙型肝炎有效，ＳＣＥ可作为乙肝抗病毒治疗药物疗效判断指标。     

试论当前我国卫生投入的合理取向

自2003年下半年以来，我国许多地区投入巨资用于发展卫生事业的消息不断见诸报端。其投入方向也不尽相同，有以建设公共卫生设施为主，有以增强疾病预防控制能力、提升突发公共卫生事件应急整体水平为主，也有以打造医疗“航空母舰”，着力建设现代化医院，以适应大型、特大型城市发展的需要，适应加入WTO后医疗市场的激烈竞争。那么，究竟应当如何看待当前我国卫生投入的不同取向?换言之，     

阿维菌素长效缓释剂的驱虫效果

寄生虫病是危害新疆养羊业最大的疾病之一。由新疆畜牧科学院院和新疆医科大联合研制的阿维菌素长效缓释制剂药效长、用量小、安全范围广，对体内外寄生虫均有较好的驱杀作用。我们在新疆阿勒泰、哈巴河和福海县三个县市的8个乡镇的101784只（次）羊进行该制剂的推广试验。结果表明在注射该制剂后的120d内羊群的感染率低于20％，可以代替一年两次的药浴。该缓释制剂的推广应用将大大提高绵羊寄生虫病的防治水平及效率，减少由寄生虫病所带来的经济损失。     

大鼠脑缺血再灌注半暗带β淀粉样前蛋白mRNA表达与梗死体积的关系

为了探讨大鼠局灶性脑缺血再灌注缺血半暗带β淀粉样前蛋白(APP)转录水平与缺血时间及梗死体积的相互关系,用插线法建立大鼠局灶性脑缺血再灌注模型,剥取缺血半暗带皮质组织,采用半定量逆转录-聚合酶链式反应(RT-PCR),测定永久性缺血48 h和不同缺血时间再灌注48 h后,APPmRNA水平的变化.结果显示,梗死体积随再灌注前缺血时间的延长而增大,皮质半暗带缺血30 min再灌注48 h APPmRNA表达升高;缺血60min和缺血120 min再灌注48 h APPmRNA升高明显;缺血180 min再灌注48 h和永久性缺血48 h APPmRNA达到高峰.提示缺血半暗带APPmRNA的表达随再灌注前缺血时间延长而增加并与梗死体积有一定的相关性,早期再灌注可减少其表达.((GFDAl))     

PRE- AND POST-OPERATIVE HYPOTHALAMIC-PITUITARY- THYROIDAL AXIS FUNCTION IN PATIENTS WITH PROLACTINOMA, GROWTH HORMONE TUMOUR AND ACTH TUMOUR

Pre- and postoperative hypothalamic-pituitary-thyroid axis function was studied in 38 patients with pituitary adenomas (PRL, GH and ACTH tumours), of whom 35 were surgically confirmed and three diagnosed by clinical signs, CT scanning and hormone assessments. About ten days after operation, the same study was repeated in 10 patients with prolactinoma and 7 with growth hormone (GH) tumour. The preoperative abnormal serum TSH response to TRH was found in 8/20 patients with prolactinoma, 9/16 with GH tumour, and 2/2 with Cushing's disease due to ACTH microadenoma. The incidence of abnormal TSH response to TRH was not significantly increased in patients with larger adenoma in either PRL or GH tumour group. In 8 cases of prolactinoma, metoclopramide (MCP, 10 mg, P.O.) test was also performed and there was a significant positive correlation between TSH responses to TRH and to MCP. Serum TT3 in the GH tumour group was within normal ranges, but significantly higher than that of the normal and prolactinoma groups. After operation, TT3 was significantly decreased as compared with that before operation and there were marked changes in TSH response to TRH. In conclusion, there were some abnormalities in TSH control in patients with non-TSH pituitary tumour, and in serum TT3 control in patients with GH tumour. The surgical treatment of pituitary adenoma can lead to transient decrease in TSH reserve and serum TT3 level probably resulting from both stress and/or destruction of thyro-trophs by the operation.     

即刻玻璃离子暂时冠的临床应用初探

金属烤瓷冠修复体因其色形逼真，坚固耐磨，口感舒适，性能稳定而在临床上被大多数患者接受。因金瓷修复体牙体切磨较多，距离髓腔近，临时修复体的制作也被重视起来。目前，临时修复体的制作材料为自凝甲基丙烯酸甲酯(自凝塑料)，分为口内法和口外法两种，两种方法中特别是口内法都存在着自凝塑料调合物中单体对牙髓牙龈的毒性刺激，在聚合的过程中会产热，有引起急慢性牙髓炎及牙髓变性的可能性；而口外法患者需复诊两次，两次之间患者要忍受基牙一系列敏感症状，增加患者的痛苦。本文对玻璃离子作为临时修复体的制作材料，即刻完成暂时冠…