1例帕金森伴异动症患者口服普拉克索致双下肢水肿的病例分析

普拉克索是一种广泛应用各期帕金森病治疗的药物,虽然疗效较好,但是近年来其所产生的不良反应时有报道。主要就1例帕金森伴异动症患者口服普拉克索导致双下肢水肿的病例进行分析。     

黄芩素的制备及抗肿瘤药理作用研究进展

目的：黄芩是我国传统的中草药,黄芩中的活性成分具有广泛的药理作用,近年来对其药理作用尤其抗肿瘤的研究成为热点。本文综述近年黄芩的活性成分黄芩素的提取分离及抗肿瘤的药理作用。     

Clinical and pathological studies of borderline gastrointestinal stromal tumors

Background To characterize borderline gastrointestinal stromal tumors (GISTs) and identify a set of borderline criteria for practical use. Methods Medical records and specimens of 840 patients from 12 hospitals were retrospectively examined. 485 and 76 patients with any of the parameters predictive of either malignant or benign tumors were excluded. The Kaplan-Meier method was used to calculate disease-free survival and overall survival rates. Results Among the remaining 279 borderline GIST patients, 223 were followed for time periods ranging from 1 to 31.48 years. Two patients developed local recurrence, and both were cured by subsequent operations alone. The 5-year disease-free survival and overall survival rates were 99% and 100%, respectively. Morphologically, borderline GISTs typically exhibited moderate cellularity, and subsets of them also showed moderate atypia, low mitotic activities, or large tumor size. According to the NIH (National Institutes of Health) consensus criteria, the risk levels of the 279 GISTs were classified to be very low to high. However, the disease-free survival rates were not significantly different among these risk groups (P = 0.681). Conclusions The proposed borderline GIST criteria in the current study may complement the existing NIH criteria, based primarily on tumor size and mitotic count, in the evaluation of the biological behaviors of GISTs. Since a subset of borderline GISTs with high risk level showed favorable outcome, the introduction of the borderline GIST system may avoid over-diagnosis and over-therapy.     

儿童感音神经性聋139例回顾性病因分析

本文对139例感音神经性聋患儿的病因、听功能进行回顾性分析。 资料与方法 一、临床资料2000年1月-2007年10月在我科治疗的感音神经性聋患儿139例234耳,双耳病变95例190耳,单耳病变44例,其中男89例158耳,女50例76耳。年龄4～15岁,平均9．5岁。     

老年2型糖尿病患者抑郁相关因素的调查

目的 了解老年2型糖尿病患者抑郁发生率及相关影响因素,为实施针对性干预提供依据.方法 采用Zung抑郁自评量表(SDS)与日常生活自理能力量表对158例老年2型糖尿病患者进行调查.结果 60例(38.5%)老年2型糖尿病患者发生抑郁.抑郁发生率因性别、糖化血红蛋白、病程、并发症数目、日常生活自理能力而存在统计学差异(P＜0.05,P＜0.01).病程长、并发症多及日常生活自理能力缺陷是其抑郁发生的重要危险因素(均P＜0.01,OR分别为5.183、2.216、3.042).结论 老年2型糖尿病患者抑郁发生率高,在常规药物、饮食、运动、血糖监测治疗同时,对病程长、并发症多和日常生活自理能力缺陷者重视心理干预及健康教育,将有利于控制病情,改善其生活质量.     

慢性苯中毒患者的心理分析与护理

目的分析慢性苯中毒患者的状况,研究护理方法和策略。方法对92例慢性苯中毒患者进行心理分析、临床治疗、一般护理、康复指导。结果本组92例患者经过心理分析和护理,治愈47例,有效41例,无效4例。结论慢性苯中毒一般病程较长、病情较重,优质的护理配合临床治疗能够有效帮助患者早日康复。     

重组人促红细胞生成素相关性纯红细胞再生障碍性贫血

重组人促红细胞生成素(rhEPO)是治疗肾性贫血的首选药物,目前全球有数百万慢性肾脏病(CKD)患者正在接受rhEPO治疗,在rhEPO开始使用的10年间,全球仅报道3例因rhEPO导致的纯红细胞再生障碍性贫血(PRCA),以后的病例报道逐渐增多。截至2002年底,全世界已报道PRCA患者200余例[1]。促     

动力髁螺钉治疗股骨粗隆间骨折生物力学的研究

[目的]探讨动力髁螺钉治疗股骨粗隆间骨折的疗效。[方法]采用动力髁螺钉治疗股骨粗隆间骨折17例。[结果]术后经6~20个月,平均9个月的随访;功能恢复按黄公怡[1]评价标准:优11例,良4例,优良率为88.24%。[结论]从生物力学角度分析:动力髁螺钉可用于动力髋螺钉不合适治疗股骨逆粗隆间骨折和股骨粗隆下极区域内严重粉碎性骨折类型骨折。     

胺碘酮联用缬沙坦治疗阵发性房颤临床疗效观察

目的：观察口服胺碘酮联合应用血管紧张素II受体拮抗剂（ARB）缬沙坦在阵发性心房颤动复律后维持窦律的疗效。方法：将145例阵发性房颤分为胺碘酮组（I组，n=72），胺碘酮加缬沙坦组（Ⅱ组，n=73），疗效观察24个月。结果：治疗6个月后两组左心房内径无显著差异，但12个月后两组有显著差异（p〈0．05），窦性心律维持12个月后有显著差异（p〈0．05）。结论：胺碘酮与缬沙坦联合治疗阵发性房颤维持，窦性心律的疗效优于单用胺碘酮，并能延缓左心房扩大。