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61.
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Renda MC Makrydimas G Nicolaides KH Fecarotta E Damiani G Picciotto F Jakil MC Maggio A 《European journal of haematology》2007,79(5):435-438
Coelocentesis offers a new opportunity for gaining access to the human embryos from 28 d postfertilization. However, while some studies about its biochemical composition have been reported, our knowledge about immunological pattern of this compartment is still limited. For this reason, we studied the human coelomic fluids sampled from 6.6 to 10 wk of gestation. The majority of cellular population consisted in mesenchymal/epithelial cells. In fluids sampled before 10 wk we found only a preT Cell Receptor expression and an absence or a very low frequency of B lymphocytes, T lymphocytes and NK (natural killer) antigens. These preliminary data suggest that the immunological system in human embryos could be in the ideal conditions to start a process of tolerance induction. 相似文献
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Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia 下载免费PDF全文
66.
Maggio A 《British journal of haematology》2007,138(4):407-421
This review outlines the main chelator groups studied to date, and the evidence for their clinical effectiveness. For each treatment, the strength of evidence was documented according to the guidelines from the American College of Cardiology and the American Heart Association. Three main haematological diseases were considered as models: thalassaemia major, sickle-cell disorders and myelodysplasia. Although the data in the literature do not allow firmly evidence-based conclusions, the findings suggest that in thalassaemia major: (i) deferoxamine remains the drug of choice for chelation treatment; (ii) if there is deferoxamine intolerance or a change of treatment is suggested, the options are deferiprone or, if the liver iron concentration is high, deferasirox treatment; and (iii) if the ferritin level is >2500 microg/l and liver iron concentation is >7 mg/g/dry weight, continuous subcutaneous (s.c.) or intravenous (i.v.) deferoxamine, or combined treatment with deferiprone and deferoxamine is advised. In case of heart failure, there is currently more solid documentation to support continuous s.c. or i.v. deferoxamine treatment than combined treatment with deferiprone and deferoxamine. However, more recent data in the literature suggest that the latter could be a satisfactory alternative. Finally, if iron chelation is required for sickle-cell disorders or myelodysplastic syndromes, the current data support the use of deferoxamine treatment. 相似文献
67.
Maggio R Peragine N Calabrese E De Propris MS Intoppa S Della Starza I Ariola C Vitale A Foà R Guarini A 《Leukemia & lymphoma》2007,48(2):302-310
The capacity to generate effective dendritic cells (DC) from adult acute lymphoblastic leukemia (ALL) patients in complete remission (CR) and off-therapy was investigated. Monocyte-derived DC cultured in the presence of granulocyte-macrophage colony-stimulating factor, interleukin (IL)-4 and tumor necrosis factor (TNF)-alpha expressed maturation markers, produced IL-12 and loaded apoptotic bodies to a similar extent to normal DC. Patients' circulating T and NK lymphocytes were normally represented and, after stimulation, were capable of producing TNF-alpha and interferon-gamma to a similar extent to control lymphocytes. DC loaded with leukemia-derived apoptotic bodies increased their ability to stimulate both allogeneic and autologous lymphocytes, and to generate specific anti-leukemic CD3 + cells. These findings offer a rationale for the design of DC-based vaccine programs for adult ALL patients in CR with the aim of controlling/eradicating the disease. 相似文献
68.
Maggio Emilia Mete Maurizio Sartore Mauro Bauci Francesco Guerriero Massimo Polito Antonio Pertile Grazia 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2022,260(3):807-815
Graefe's Archive for Clinical and Experimental Ophthalmology - To report a longitudinal analysis of specific optical coherence tomography (OCT) features in eyes with diabetic macular edema... 相似文献
69.
Real money: complications and hospital costs in trauma patients 总被引:1,自引:0,他引:1
Hemmila MR Jakubus JL Maggio PM Wahl WL Dimick JB Campbell DA Taheri PA 《Surgery》2008,144(2):307-316
70.
E. Nettis M. Marcandrea G. Di Maggio A. Ferrannini A. Tursi 《Immunopharmacology and immunotoxicology》2001,23(4):585-595
Urticaria and angioedema (UA) represent a syndrome that is frequently encountered in children and adults. However, although they are often associated (in up to 50% of some patient populations), these two clinical entities should not be considered synonymous because they have distinct clinical and histopathological characteristics. The frequency of UA in drug-induced pathologies is quite high
Here we report a retrospective survey of 2287 patients, observed between 1988 and 1997 presenting one or more episodes of drug-induced UA. In 1973 patients (86.2%) [639 (32.4%) males and 1334 (67.6%) females] a specific drug responsible for UA was identified. Particularly over the last two years the frequency of drug-induced UA has tended to increase, being more prevalent in females and the majority of cases (576: 23.1%) occuring during the third decade of life.
The most frequently involved drugs are anti-inflammatory (particularly acetylsalicylic acid) and antimicrobial agents (mainly β-lactams). 相似文献
Here we report a retrospective survey of 2287 patients, observed between 1988 and 1997 presenting one or more episodes of drug-induced UA. In 1973 patients (86.2%) [639 (32.4%) males and 1334 (67.6%) females] a specific drug responsible for UA was identified. Particularly over the last two years the frequency of drug-induced UA has tended to increase, being more prevalent in females and the majority of cases (576: 23.1%) occuring during the third decade of life.
The most frequently involved drugs are anti-inflammatory (particularly acetylsalicylic acid) and antimicrobial agents (mainly β-lactams). 相似文献