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51.
Francesco Bandello Marco Coassin Antonio Di Zazzo Stanislao Rizzo Ilaria Biagini Nadezhda Pozdeyeva Maksim Sinitsyn Alexander Verzin Pasquale De Rosa Francesco Calabr Teresio Avitabile Vincenza Bonfiglio Francesco Fasce Rafael Barraquer Jos Lamarca Mateu Thomas Kohnen Marino Carnovali Boris Malyugin Group LEADER- Investigators 《Eye (London, England)》2020,34(11):2112
BackgroundCataract surgery is the most common operation performed worldwide. A fixed topical corticosteroid-antibiotic combination is usually prescribed in clinical practice for 2 or more weeks to treat post surgical inflammation and prevent infection. However, this protracted schedule may increase the incidence of corticosteroid-related adverse events and notably promote antibiotic resistance.MethodsThis International, multicentre, randomized, blinded-assessor, parallel-group clinical study evaluated the non-inferiority of 1-week levofloxacin/dexamethasone eye drops, followed by 1-week dexamethasone alone, vs. 2-week gold-standard tobramycin/dexamethasone (one drop QID for all schedules) to prevent and treat ocular inflammation and prevent infection after uncomplicated cataract surgery. Non-inferiority was defined as the lower limit of the 95% confidence interval (CI) around a treatment difference >–10%. The study randomized 808 patients enrolled in 53 centres (Italy, Germany, Spain and Russia). The primary endpoint was the proportion of patients without anterior chamber inflammation on day 15 defined as the end of treatment. Endophthalmitis was the key secondary endpoint. This study is registered with EudraCT code: 2018-000286-36.ResultsAfter the end of treatment, 95.2% of the patients in the test arm vs. 94.9% of the control arm had no signs of inflammation in the anterior chamber (difference between proportions of patients = 0.028; 95% CI: −0.0275/0.0331). No case of endophthalmitis was reported. No statistically significant difference was evident in any of the other secondary endpoints. Both treatments were well tolerated.ConclusionsNon-inferiority of the new short pharmacological strategy was proven. One week of levofloxacin/dexamethasone prevents infection, ensures complete control of inflammation in almost all patients and may contain antibiotic resistance.Subject terms: Health care, Drug therapy 相似文献
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Capuano Vittorio Sacconi Riccardo Borrelli Enrico Miere Alexandra Gelormini Francesco Farci Roberta Bandello Francesco Souied Eric H. Querques Giuseppe 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(8):1597-1605
Graefe's Archive for Clinical and Experimental Ophthalmology - To describe the “dimple,” a previously unreported structural optical coherence tomography (OCT) finding in... 相似文献
54.
Francesco Bandello Marco Coassin Antonio Di Zazzo Stanislao Rizzo Ilaria Biagini Nadezhda Pozdeyeva Maksim Sinitsyn Alexander Verzin Pasquale De Rosa Francesco Calabr Teresio Avitabile Vincenza Bonfiglio Francesco Fasce Rafael Barraquer Jos Lamarca Mateu Thomas Kohnen Marino Carnovali Boris Malyugin Group LEADER- Investigators 《Eye (London, England)》2020,34(11):2150
55.
Giuffrè Chiara Cicinelli Maria Vittoria Marchese Alessandro Coppola Michele Parodi Maurizio Battaglia Bandello Francesco 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(4):787-793
Graefe's Archive for Clinical and Experimental Ophthalmology - To assess the functional and anatomical outcomes of concurrent administration of aflibercept injection and dexamethasone (DEX)... 相似文献
56.
Effect of chromogranin A‐derived vasostatin‐1 on laser‐induced choroidal neovascularization in the mouse 下载免费PDF全文
57.
Marina Trento Pietro Passera Martina Trevisan Francesca Schellino Elena Sitia Stefano Albani Marcello Montanaro Francesco Bandello Lucia Scoccianti Lorena Charrier Franco Cavallo Massimo Porta 《Acta diabetologica》2013,50(6):873-877
Diabetic retinopathy may induce visual impairment. We evaluated vision-related quality of life in patients with visual acuity <5/10 in the better eye induced by retinopathy using the 25-item National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25). The NEI VFQ-25 was self-administered to 196 patients in 3 Italian centres (A, B and C; n = 64, 61 and 71, respectively) dedicated to DR screening and treatment. Patients in the 3 centres did not differ by age, gender, occupation and diabetes duration. Multivariate analysis demonstrated that reduced visual acuity was associated with decreased scores for General Vision, Near Activities, Distance Activities, Visual-Specific Social Functioning, Mental Health, Role Difficulties and Dependency, Driving, Colour Vision and Peripheral Vision (p < 0.01, all). Treatment by photocoagulation was associated with reduced scores in General Health (?8.3; p = 0.002), General Vision (?7.2; p = 0.001), Visual-Specific Role Difficulties (?8.8; p = 0.015) and Driving (?13.7; p = 0.003). Centre affiliation was associated with different scores for General Health, Ocular pain, Distance Activities, Visual-Specific Social Functioning and Role Difficulties and Peripheral Vision. Women had higher scores for General Vision (p = 0.015), Near Activities (p = 0.005), Distance Activities (p = 0.006), Visual-Specific Social Functioning (p = 0.03), Visual-Specific Mental Health (p = 0.035) and Colour Vision (p = 0.012). Diabetic retinopathy and vision loss modify the way people perceive their own ability to function autonomously. More data should be collected to confirm this interpretation and to guide the development of more appropriate settings to improve approach and support to patients. 相似文献
58.
Evolving European guidance on the medical management of neovascular age related macular degeneration
59.
Lanzetta P Polito A Del Borrello M Narayanan R Shah VA Frattolillo A Bandello F 《American journal of ophthalmology》2006,142(5):771-776
PURPOSE: To evaluate the efficacy of pars plana vitrectomy with infracyanine green (IFCG)-assisted internal limiting membrane peeling for the treatment of idiopathic macular hole. DESIGN: Prospective, noncomparative interventional case series. METHODS: Thirty-eight consecutive eyes of 35 patients with idiopathic macular hole were included in the study. Patients underwent early treatment diabetic retinopathy (ETDRS) visual acuity examination, dilated ophthalmoscopy, and optical coherence tomography before treatment and during follow-up. Fluorescein angiography was done in selected cases. Patients underwent a three-port pars plana vitrectomy with complete posterior hyaloid and epiretinal membrane removal. The internal limiting membrane (ILM) was stained with 0.5 cc of IFCG (0.5 mg/ml, 308 mOsm) and peeled up to the vascular arcades. Perfluoropropane gas (C(3)F(8)) 10% was used as tamponade. RESULTS: Mean follow-up duration was 10 +/- 5 months (range, 3 to 24 months). Six eyes had stage 2 macular hole, 15 eyes stage 3, and 16 eyes stage 4. Overall, 37 of 38 macular holes closed after a single surgery. Median visual acuity was 20/100 (range, 20/400 to 20/50) before surgery and 20/50 (range, 20/640 to 20/25) after surgery. Visual acuity after surgery was 20/50 or better in 24 of 38 (63.1%) eyes. Twenty-five (65.8%) eyes improved by 2 or more lines, nine (23.7%) eyes were stable, and four (10.5%) eyes worsened by 2 or more lines. CONCLUSIONS: This study suggests that IFCG (0.05%) effectively stains the ILM with apparent safety, and that IFCG-assisted peeling of the ILM may be useful in the treatment of idiopathic macular hole. 相似文献
60.
Parodi MB Di Crecchio L Lanzetta P Polito A Bandello F Ravalico G 《American journal of ophthalmology》2004,138(2):263-269
PURPOSE: Evaluation of visual acuity outcomes of photodynamic therapy with verteporfin for subfoveal choroidal neovascularization (CNV) secondary to multifocal choroiditis. DESIGN: Open-label, prospective, interventional case series. METHODS: Thirteen patients (13 eyes) diagnosed with subfoveal CNV associated with multifocal choroiditis at the Eye Clinics of Trieste and Udine were considered for the study. Inclusion criteria were the presence of subfoveal CNV no larger than 5,400 microm in greatest linear dimension and best-corrected visual acuity, Snellen equivalent, of approximately 20/400 or better. The primary outcome was the number of eyes that had fewer than 8 letters lost (less than approximately 1.5 lines) at the 12-month examination compared with the baseline examination. Secondary outcomes included fluorescein angiographic features such as progression and CNV size. RESULTS: Baseline and final best-corrected visual acuity were 0.52 logarithm of the minimal angle of resolution (20/62(-2) Snellen equivalent) and 0.55 logarithm of the minimal angle of resolution (20/62(-2) Snellen equivalent), respectively. By the 12-month visit, one patient (7.7%) had gained at least 1.5 lines, two patients (15.4%) had lost 1.5 or more lines, and no patient lost 3 or more lines of visual acuity, whereas 10 patients (84.6%) showed less than 1.5-line change. Mean CNV area was 0,69 mm(2) and 0.63 mm(2) at baseline and at the 12-month visit, respectively. By the month 12 examination, patients had received an average of 1.7 treatments. CONCLUSIONS: Photodynamic therapy may be considered a viable therapeutic option for subfoveal CNV associated with multifocal choroiditis at least for a 1-year period. Further studies with longer follow-up are needed to confirm these results. 相似文献