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31.
Design,synthesis, biological evaluations,molecular docking,and in vivo studies of novel phthalimide analogs 下载免费PDF全文
Magdy A. H. Zahran Bishoy El‐Aarag Ahmed B. M. Mehany Amany Belal Ali S. Younes 《Archiv der Pharmazie》2018,351(5)
32.
Younes El-Kardi Ali Jafri Amal Anide Abdelfettah Derouiche 《Nutrition Clinique et Métabolisme》2018,32(1):33-36
Introduction
High salt intake is associated with high blood pressure. This pilot study aimed to measure the salt content of some fast foods in Casablanca, Morocco.Materials and methods
Thirty-eight fast foods were collected from different snacks and restaurants in Casablanca, between 1st March and 30th May 2014. Six types of fast foods were targeted: tuna sandwich (n = 8), merguez sandwich (n = 8), minced meat sandwich (n = 6), eggs sandwich (n = 6), shawarma (n = 6) and pizza (n = 4). The total weight of each fast food was recorded and then each sandwich was cut and mixed until homogeneous doughs using a mixer robot. The doughs obtained were immediately put in plastic food bags and frozen at ? 20 ?C until analysis. Analysis of the sodium content was carried out according to the Mohr method in an accredited public laboratory.Results
The sodium content values were from 0.25 g/100 g (0.62 g of salt/100 g) in minced meat sandwiches to 0.44 g/100 g (1.1 g of salt/100 g) in pizzas. Salt content expressed per individual serving showed that the pizzas had the highest average amount (2.62 g/serving), while the minced meat sandwiches had the lowest average amount (1.42 g/serving). These values varied according to portion size.Conclusion
This pilot study showed for the first time in Morocco that salt content of some fast foods is higher and consumption of only one serving of these fast foods can exceed half of the daily recommendation of salt (5 g/day). 相似文献33.
Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis 下载免费PDF全文
Laurent Younes J. Tilak Ratnanather Timothy Brown Elizabeth Aylward Peg Nopoulos Hans Johnson Vincent A. Magnotta Jane S. Paulsen Russell L. Margolis Roger L. Albin Michael I. Miller Christopher A. Ross PREDICT‐HD Investigators Coordinators of the Huntington Study Group 《Human brain mapping》2014,35(3):792-809
Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT‐HD study, we use statistical shape analysis with deformation markers obtained through “Large Deformation Diffeomorphic Metric Mapping” of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico‐basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention. Hum Brain Mapp 35:792–809, 2014. © 2012 Wiley Periodicals, Inc. 相似文献
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Hepatitis viral infections are important causes of morbidity and mortality in haemodialysis patients. The aim of the present work is to study the prevalence and possible risk factors of hepatitis C virus (HCV), hepatitis B virus (HBV) and dual infection in haemodialysis patients. Three hundred forty patients with end-stage renal disease, 266 males (78.2%) with mean age of 50.9?±?11.6 years and 74 females (21.8%) with mean age of 53.5?±?10.5 years on haemodialysis, were recruited from four haemodialysis units. They were screened for the presence of HCV, HBV and dual HCV and HBV infections and possible risk factors for acquiring these infections in those patients during the period between June 2007 and August 2009. One hundred ninety-six (57.7%) patients were HCV positive while 12 (3.5%) patients had HBV infection. A dual infection with both viruses was observed in 26 patients (7.6%).There was a significant difference in the number of blood transfusions among HCV-positive, HBV-positive and dual infection patients and negative patients (12.4?±?7.6, 13.8?±?6.8, 13.5?±?8.3 vs. 5.2?±?3.4 transfusions, p?<?0.01). HCV, HBV and dual HCV and HBV patients have been on dialysis for a longer period than the negative patients (7.5?±?5, 6.2?±?3.6, 7.5?±?5.4 vs. 4.4?±?4 years, p?<?0.01). Higher HCV was associated with longer haemodialysis duration and history of previous blood transfusion and not associated with dialysis in multicentres. HBV and dual infection is less prevalent than HCV in haemodialysis units. 相似文献
37.
Comparison of the postprandial release of peptide YY and proglucagon-derived peptides in the rat 总被引:4,自引:0,他引:4
Younes Anini Xiaomei Fu-Cheng Jean Claude Cuber Alain Kervran Jacques Chariot C. Rozé 《Pflügers Archiv : European journal of physiology》1999,438(3):299-306
Endocrine L-cells of the distal intestine synthesize both peptide YY (PYY) and proglucagon-derived peptides (PGDPs), whose
release has been reported to be either parallel or selective. Here we compare the release mechanisms of PYY, glucagon-like
peptide-1 (GLP-1), and oxyntomodulin-like immunoreactivity (OLI) in vivo. Anaesthetized rats were intraduodenally (ID) given
either a mixed semi-liquid meal or oleic acid, or they received oleic acid or short chain fatty acids (SCFA) intracolonically
(IC). The ID meal released the three peptides with a similar time-course (peak at 30 min); ID oleic acid produced a progressive
release of PYY and OLI, while GLP-1 release was less. IC oleic acid or SCFA released smaller (but significant) amounts of
PYY but no OLI or GLP-1. Hexamethonium inhibited most of the response to the ID meal and ID oleic acid, but did not change
the PYY response to IC oleic acid. N
G
-nitro-l-arginine methyl ester (l-NAME, a nitric oxide synthase inhibitor) inhibited meal-induced PYY release and left OLI and GLP-1 unaffected. BW10 (a gastrin-releasing
peptide antagonist) had no effect on the meal-induced release of either peptide. These results suggest a parallel initial
release of PYY, OLI and GLP-1 after the ID meal, or oleic acid, by an indirect mechanism triggered in the proximal bowel,
using nicotinic synapses, and involving nitric oxide release for PYY and an unknown mediator for PGDPs. For PYY there is a
later phase of peptide release, probably induced by direct contact between nutrients and colonic L-cells.
Received: 8 January 1999 / Received after revision: 25 March 1999 / Accepted: 26 April 1999 相似文献
38.
Mariam Siala Nadia Mahfoudh Radhouane Gdoura Mohamed Younes Hela Fourati Arwa Kammoun Ilhem Chour Nihel Meddeb Lilia Gaddour Faiza Hakim Sofien Baklouti Naceur Bargaoui Sleheddine Sellami Adnene Hammami Hafedh Makni 《Rheumatology international》2009,29(10):1193-1196
The purpose of the present study is to investigate the frequency of HLA-B27 and its alleles in reactive arthritis (ReA) and
in ankylosing spondylitis (AS) in Tunisia. HLA-B27 alleles were typed by PCR amplification with sequence-specific primers.
We studied 17 patients with ReA associated with urethritis or with gastrointestinal infection; 42 HLA-B27-positive patients
with AS and 100 healthy controls. Eleven ReA patients (67.7%) were HLA-B27 positive. There was an increased frequencies of
HLA-B27 (P = 7.76 × 10−12, OR = 59.30) and a moderate increase of HLA-B51 (P = 0.015; OR = 4.91) alleles in ReA patients when compared with healthy controls. Four B27 subtypes were identified: B*2702,
05, 09 and B*2712. The distribution of these alleles in the ReA patients was 37.5% for B*2702 and B*2705. Only these two subtypes
were detected in 18 (42.8%) and 24 (57.1%), respectively, of the AS patients. B*2709 and B*2712 were relatively rare in ReA
patients and were identified in one case each. Our results showed a restricted number of HLA-B27 subtypes associated with
ReA and AS. B*2702 and 2705 were common in ReA and AS patients. 相似文献
39.
Younes S Labssita Y Baziard-Mouysset G Payard M Rettori M Renard P Pfeiffer B Caignard D 《European journal of medicinal chemistry》2000,35(1):107-121
Continuing our previous work that established that some chromones substituted by an aryl alkyl piperazino alkyl side chain are potent and selective sigma ligands and could be interesting in the treatment of psychosis, we synthesized 60 new compounds, replacing the chromone moiety by various cyclic systems. Many derivatives bind to the sigma sites in the nanomolar range and are generally selective in comparison with 5HT(1A) and the D(2) receptors. One of the most potent ligands of these series, 1-(2-naphthyl methyl)-4-benzyl piperazine 29, has been studied in various pharmacological tests. Although it doesn't have potential in the treatment of psychosis, the results we obtained confirm the data which indicates that such derivatives could be interesting in the treatment of inflammatory diseases. 相似文献
40.