EFFECTS OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE IV INHIBITOR, Ro20,1724, ON PANCREATIC EXOCRINE SECRETION IN DOG

1. The effects of the cyclic nucleotide phosphodiesterase (PDE) inhibitors, Ro20,1724, 3-isobutyl-1-methylxanthine (IBMX), trifluoperazine (TFP) and amrinone on pancreatic exocrine secretion were investigated in anaesthetized dogs in comparison with those of secretin and cholecystokinin octapeptide (CCK-8). 2. Ro20,1724 (1–30 nmol/kg), IBMX (3–30 nmol/kg), secretin (0.01–0.1 pmol/kg) or CCK-8 (0.1–1 pmol/kg) injected i.a. elicited a dose-dependent increase in the secretion of pancreatic juice, but TFP and amrinone (up to 1 μmol/ kg) did not. 3. The bicarbonate concentration in pancreatic juice was increased and the protein concentration was decreased by Ro20,1724, IBMX and secretin. Cholecystokinin octapeptide increased the protein concentration but did not alter the bicarbonate concentration. 4. Ro20,1724 and IBMX elicited more than the respective additive secretory response when added together with secretin, although the stimulatory effects of CCK-8 with Ro20,1724 and IBMX were additive. 5. Ro20,1724 and IBMX increased cyclic AMP concentration but did not affect cyclic GMP concentration. 6. These results suggest that Ro20,1724 and IBMX have secretory properties on pancreatic exocrine glands of the dog, which may be mediated through an increase in cyclic AMP subsequent to inhibition of PDE activity. Furthermore, pancreatic PDE enzymes in the dog may be mainly type IV.     

高强度训练法对新兵心理健康的作用

目的探索高强度训练法在新兵心理健康及维护中的作用。方法调查驻四川某部队2006年度新兵,将其随机分成研究组和对照组。研究组应用高强度训练法进行干预3个月,对照组只进行一般的行为干预。干预前后分别对研究组和对照组进行SCL-90问卷调查。结果干预前,研究组与对照组SCL-90各因子分比较,均无统计学差异(P>0.05)。研究组因子分≥3分者占2.9%~6.3%,对照组因子分≥3分者占2.9%~6.4%。研究组总分>160分者占32.40%,阳性项目分数>43分者占30.76%;对照组总分>160分者占32.13%,阳性项目分数>43分者占30.81%。干预后,研究组与对照组SCL-90各因子分比较,强迫、抑郁、焦虑、敌对性、恐怖、其他、总均分、阳性项目数和阳性症状均分统计学差异显著(P<0.01);躯体化、人际关系差异有统计学意义(P<0.05);偏执、精神病性无差异(P>0.05)。研究组因子分≥3分者占1.5%~4.9%,对照组因子分≥3分者占2.7%~6.0%。研究组总分>160分者占15.46%,阳性项目分数>43分者占13.98%;对照组总分>160分者占25.70%,阳性项目分数>43分者占22.90%。结论高强度训练法在新兵心理健康及维护中具有重要作用。     

肾盂切开气压弹道碎石治疗鹿角形肾结石(附46例报告)

目的 探讨肾盂切开气压弹道碎石治疗鹿角形肾结石的疗效。方法 对46例鹿角形肾结石采用肾盂切开气压弹道碎石，将结石分解成数块，再逐一取出。双侧肾结石采用一次分侧手术取石。结果 46例鹿角形肾结石均较顺利取出，无黏膜撕脱、出血等并发症。25例肾功不全者均显著改善。结论肾盂切开结合气压弹道碎石是治疗鹿角形肾结石较好方法；双侧肾结石多有梗阻致肾功能受损，应双侧一次取石，有利于双肾功能恢复。     

护士配制表柔比星致自身变态反应1例

表柔比星为半合成的第2代蒽环类抗生素，为多柔比星的同分异构体，4-位置上的羟基由顺式变为逆式。这种立体结构上的细微变化提高了抗肿瘤的治疗指数，且降低了骨髓和心脏的毒性。因此，该药目前临床上广泛用于抗肿瘤的治疗。但我院1名护士在配制表柔比星时出现变态反应，现介绍如下。     

Health status,work limitations,and return-to-work trajectories in injured workers with musculoskeletal disorders

BACKGROUND: The purpose of this study was to describe the health status and work limitations in injured workers with musculoskeletal disorders at 1 month post-injury, stratified by return-to-work status, and to document their return-to-work trajectories 6 months post-injury. METHODS: A sample of 632 workers with a back or upper extremity musculoskeletal disorder, who filed a Workplace Safety and Insurance Board lost-time claim injury, participated in this prospective study. Participants were assessed at baseline (1 month post-injury) and at 6 months follow-up. RESULTS: One month post-injury, poor physical health, high levels of depressive symptoms and high work limitations are prevalent in workers, including in those with a sustained first return to work. Workers with a sustained first return to work report a better health status and fewer work limitations than those who experienced a recurrence of work absence or who never returned to work. Six months post-injury, the rate of recurrence of work absence in the trajectories of injured workers who have made at least one return to work attempt is high (38%), including the rate for workers with an initial sustained first return to work (27%). CONCLUSIONS: There are return-to-work status specific health outcomes in injured workers. A sustained first return to work is not equivalent to a complete recovery from musculoskeletal disorders.     

Synthesis of 14C‐labeled piperidines and application to synthesis of [14C]SCH 351125, a CCR5 receptor antagonist

1‐Benzyl‐4‐hydroxy[2‐¹⁴C]piperidine, a useful intermediate in labeled compound synthesis, was prepared from [¹⁴C]formaldehyde in high yield. The distribution pattern of ¹⁴C in the product is consistent with a mechanism involving reversible iminium ion formation and rapid equilibration of the iminium ion through a cationic aza‐Cope rearrangement. These steps precede the rate‐determining intramolecular cyclization step. SCH 351125 is a potent, selective CCR5 receptor antagonist with potential as a treatment for HIV infection. [¹⁴C]SCH 351125, required for metabolism studies, was prepared from 1‐benzyl‐4‐hydroxy[2‐¹⁴C]piperidine in six steps. [¹⁴C]SCH 351125 is a mixture of four atropisomers. Preparation of [¹⁴C]SCH 351125 besylate salt of the desired atropisomer pair is also described. Copyright © 2007 John Wiley & Sons, Ltd.     

Lack of spontaneous activity of cutaneous spinal dorsal horn neurons in awake, drug-free, spinally transected cats

Extracellular single-unit activity was recorded from neurons with cutaneous input in the dorsal horn of the spinal cord (L4-L6) of awake, drug-free cats before (for several weeks) and after (day 1 through day 7) cord transection (T12). The spontaneous activity of the neurons was minimal or nonexistent in both recording conditions. The lack of spontaneous activity following spinal cord transection contrasts sharply with activity recorded in acute spinal-cord transected preparations in which high rates of spontaneous activity have been reported. This discrepancy may reflect an important difference between the chronic, awake, drug-free and acute preparations.