全文获取类型
收费全文 | 2806篇 |
免费 | 296篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 86篇 |
妇产科学 | 33篇 |
基础医学 | 370篇 |
口腔科学 | 31篇 |
临床医学 | 281篇 |
内科学 | 543篇 |
皮肤病学 | 107篇 |
神经病学 | 263篇 |
特种医学 | 249篇 |
外科学 | 312篇 |
综合类 | 66篇 |
预防医学 | 341篇 |
眼科学 | 62篇 |
药学 | 202篇 |
中国医学 | 1篇 |
肿瘤学 | 155篇 |
出版年
2021年 | 36篇 |
2020年 | 35篇 |
2019年 | 48篇 |
2018年 | 50篇 |
2017年 | 46篇 |
2016年 | 48篇 |
2015年 | 58篇 |
2014年 | 75篇 |
2013年 | 66篇 |
2012年 | 135篇 |
2011年 | 119篇 |
2010年 | 73篇 |
2009年 | 55篇 |
2008年 | 112篇 |
2007年 | 111篇 |
2006年 | 105篇 |
2005年 | 100篇 |
2004年 | 99篇 |
2003年 | 90篇 |
2002年 | 105篇 |
2001年 | 106篇 |
2000年 | 88篇 |
1999年 | 66篇 |
1998年 | 53篇 |
1997年 | 40篇 |
1996年 | 62篇 |
1995年 | 40篇 |
1994年 | 51篇 |
1993年 | 49篇 |
1992年 | 85篇 |
1991年 | 74篇 |
1990年 | 62篇 |
1989年 | 65篇 |
1988年 | 47篇 |
1987年 | 55篇 |
1986年 | 71篇 |
1985年 | 67篇 |
1984年 | 44篇 |
1983年 | 38篇 |
1982年 | 35篇 |
1981年 | 32篇 |
1980年 | 43篇 |
1979年 | 27篇 |
1978年 | 16篇 |
1977年 | 16篇 |
1976年 | 17篇 |
1975年 | 15篇 |
1974年 | 21篇 |
1970年 | 15篇 |
1967年 | 14篇 |
排序方式: 共有3126条查询结果,搜索用时 15 毫秒
71.
As a consequence of inhibition of the hepatic cytochrome P450 3A4 isozyme, treatment with HIV protease inhibitors can result in significant drug?drug interactions. One noteworthy interaction is between protease inhibitors and inhaled or intranasal corticosteroids. This interaction can result in adrenal insufficiency and iatrogenic Cushing's syndrome (with symptoms such as rapid weight gain, obesity, facial hirsutism and swelling), as well as hypertension, osteoporosis and decreased CD4 cell count. In this paper, we review and unite pharmacokinetic data, case reports and current research regarding this drug?drug interaction in order to suggest options for the clinical management of HIV‐positive patients requiring treatment with protease inhibitors and inhaled or intranasal corticosteroids. 相似文献
72.
73.
John Kautter Gregory C. Pope 《International journal of health care finance and economics》2014,14(2):95-108
The traditional Medicare fee-for-service program may be able to purchase clinical laboratory test services at a lower cost through competitive bidding. Demonstrations of competitive bidding for clinical laboratory tests have been twice mandated or authorized by Congress but never implemented. This article provides a summary and review of the final design of the laboratory competitive bidding demonstration mandated by the Medicare Modernization Act of 2003. The design was analogous to a sealed bid (first price), clearing price auction. Design elements presented include covered laboratory tests and beneficiaries, laboratory bidding and payment status under the demonstration, composite bids, determining bidding winners and the demonstration fee schedule, and quality under the demonstration. Expanded use of competitive bidding in Medicare, including specifically for clinical laboratory tests, has been recommended in some proposals for Medicare reform. The presented design may be a useful point of departure if Medicare clinical laboratory competitive bidding is revived in the future. 相似文献
74.
JML Williamson M Finch-Jones I Pope 《Annals of the Royal College of Surgeons of England》2014,96(3):e1-e2
Pancreatic haemangiomas are rare benign tumours that can affect both adults and children. They have an unknown incidence and only 15 adult cases have been reported, all from histological examination. Patients present with vague symptoms relating to tumour mass or they are detected incidentally. Cross-sectional imaging is the mainstay of investigation and may reveal arterially enhancing cystic lesions but in the case presented here, it was non-diagnostic. The use of endoscopic ultrasonography confirmed the nature of the benign lesion, allowing a conservative approach as opposed to operative resection. 相似文献
75.
76.
Agnes Schwieger‐Briel M.D. Alexandra Balma‐Mena M.D. BoYee Ngan M.D. Anne Dipchand M.D. Elena Pope M.D. 《Pediatric dermatology》2010,27(5):509-513
Abstract: Immunosuppression is necessary in a large number of conditions to modify immune responses and control disease severity. It is a vital part of treatment regimes following organ and bone marrow transplants. However, the use of immunosuppressive drugs has been shown to cause infections with common and unusual pathogens. We present the case of a 5‐year‐old female heart transplant recipient. Nine months after the transplant, she developed a tender acneiform eruption on her face consisting of numerous small yellowish to pink papules and pustules. Many of the lesions had a central, firm, small spinulous excrescence or a central dell. Histopathology demonstrated abnormal maturation of the hair follicles, nucleated eosinophilic cells with trichohyalin granules. The clinical presentation and histological features were in keeping with trichodysplasia spinulosa, a rare complication in immunosuppressed subjects. Treatment trials included reduction of immunosuppression combined with topical and oral retinoids, topical acyclovir, and oral valganciclovir with limited success. 相似文献
77.
When achalasia becomes far advanced and leads to esophageal resection, inflammation of the esophageal mucosa is almost universal. The histology of the esophageal mucosa in less advanced cases of achalasia has not been firmly established. We have studied endoscopic biopsies obtained during evaluation of patients with achalasia. Two to four endoscopic biopsies from the lower esophagus of 26 patients with manometrically verified achalasia were mounted on mesh, serially sectioned, stained, coded and interpreted by two independent observers using recognized criteria. The histological findings were correlated with clinical data. Ten of 26 patients had at least one abnormal biopsy. Five of these 10 patients had a previous Heller myotomy; another patient had several pneumatic dilatations, and two other patients had endoscopically proven candida infections. Of the 16 patients with normal histology, four had prolonged stasis, five had heartburn and one patient had both heartburn and stasis. Unless the patient with achalasia has had a Heller myotomy, balloon dilatation, or a candida infection, the esophageal mucosa on biopsy appears to be within normal limits, even in patients with years of esophageal stasis or complaints of heartburn. 相似文献
78.
79.
OBJECTIVE: To determine the prescribing and monitoring practices of disease modifying antirheumatic drugs (DMARD) for Canadian rheumatologists in their treatment of rheumatoid arthritis (RA). METHODS: A survey questionnaire was mailed to 279 rheumatologists with a 70% response rate after 2 mailings. RESULTS: Antimalarials are prescribed commonly, with the preference being hydroxychloroquine (HCQ). For antimalarials, 78% do not routinely monitor laboratory results. There was wide variability in monitoring for ocular complications. Thirty-eight percent of rheumatologists never do a baseline eye examination and 39% always do. All rheumatologists frequently use methotrexate (MTX) in RA. The reported mean maximum dose for MTX was 25.1 mg/week (range 7.5-50), with 86% routinely using folate. Ninety-eight percent prescribe sulfasalazine (SSZ) for RA. Mean maximum dose prescribed for SSZ was 2.8 g/day. Most never used oral gold, while IM gold was used by 95%. Only 9% frequently use azathioprine in RA, to a mean maximum dose of 185 mg/day. Less commonly prescribed DMARD included cyclosporine (66% frequently; 25% never) and D-penicillamine (2% frequently; 53% never). There was a wide range of what exactly was monitored with respect to laboratory tests, and at what frequency, for many of the DMARD. Nearly all (99%) used combination DMARD, the most popular combination being MTX-HCQ. There were some significant differences in treatment trends when comparing year of fellowship completion, but no sex or type of practice differences were found. Those completing fellowships prior to 1984 were more likely to prescribe azathioprine (p < 0.03), chloroquine (p < 0.01) and chronic steroids (p < 0.1) in RA. There was, however, regional variability in the use of IM gold and newer DMARD--they were most prescribed in Western Canada and least in Quebec. Cyclosporine was prescribed most frequently in Quebec compared to Western Canada and least in Ontario and the Atlantic Provinces. CONCLUSION: Canadian rheumatologists are fairly similar in their use of common DMARD and combination therapies in RA. There is variability in the use of some older medications including azathioprine and chloroquine, depending on when rheumatology training was completed, and use of some drugs varies by region. 相似文献
80.
Effects of Median Nerve Neural Mobilization in Treating Cervicobrachial Pain: A Randomized Waiting List–Controlled Clinical Trial 下载免费PDF全文