全文获取类型
收费全文 | 1717篇 |
免费 | 147篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 74篇 |
妇产科学 | 56篇 |
基础医学 | 204篇 |
口腔科学 | 47篇 |
临床医学 | 186篇 |
内科学 | 422篇 |
皮肤病学 | 21篇 |
神经病学 | 154篇 |
特种医学 | 140篇 |
外科学 | 161篇 |
综合类 | 32篇 |
一般理论 | 2篇 |
预防医学 | 151篇 |
眼科学 | 26篇 |
药学 | 175篇 |
1篇 | |
中国医学 | 1篇 |
肿瘤学 | 54篇 |
出版年
2023年 | 9篇 |
2021年 | 15篇 |
2020年 | 10篇 |
2019年 | 19篇 |
2018年 | 26篇 |
2017年 | 28篇 |
2016年 | 23篇 |
2015年 | 39篇 |
2014年 | 43篇 |
2013年 | 56篇 |
2012年 | 53篇 |
2011年 | 71篇 |
2010年 | 57篇 |
2009年 | 55篇 |
2008年 | 51篇 |
2007年 | 91篇 |
2006年 | 79篇 |
2005年 | 63篇 |
2004年 | 74篇 |
2003年 | 61篇 |
2002年 | 63篇 |
2001年 | 51篇 |
2000年 | 66篇 |
1999年 | 58篇 |
1998年 | 66篇 |
1997年 | 65篇 |
1996年 | 75篇 |
1995年 | 57篇 |
1994年 | 41篇 |
1993年 | 43篇 |
1992年 | 18篇 |
1991年 | 34篇 |
1990年 | 25篇 |
1989年 | 27篇 |
1988年 | 39篇 |
1987年 | 38篇 |
1986年 | 35篇 |
1985年 | 24篇 |
1984年 | 14篇 |
1983年 | 13篇 |
1982年 | 12篇 |
1981年 | 13篇 |
1980年 | 19篇 |
1979年 | 10篇 |
1978年 | 7篇 |
1977年 | 10篇 |
1976年 | 9篇 |
1975年 | 7篇 |
1974年 | 7篇 |
1973年 | 7篇 |
排序方式: 共有1911条查询结果,搜索用时 46 毫秒
71.
72.
73.
74.
该文旨在介绍Beth Israel医疗中心采用大剂量术中放疗(HDR-IORT)治疗复发头颈癌的经验。对2001-2010年间头颈癌局部复发接受大剂量HDR-IORT的患者进行回顾分析。结果,76例患者的87个部位在肿瘤切除后接受了治疗。术后2年控制率为62%。平均总生存期为19个月,其中42%的患 相似文献
75.
76.
María?Jesús?IzquierdoEmail author Mónica?Cavia Pilar?Mu?iz Angel?LM?de Francisco Manuel?Arias Javier?Santos Pedro?Abaigar 《BMC nephrology》2012,13(1):159
Background
Treatment with selective vitamin D receptor activators such as paricalcitol have been shown to exert an anti-inflammatory effect in patients on hemodialysis, in addition to their action on mineral metabolism and independently of parathyroid hormone (PTH) levels. The objective of this study was to evaluate the additional antioxidant capacity of paricalcitol in a clinical setting.Methods
The study included 19 patients with renal disease on hemodialysis, of whom peripheral blood was obtained for analysis at baseline and three months after starting intravenous paricalcitol treatment. The following oxidizing and inflammatory markers were quantified: malondialdehyde (MDA), nitrites and carbonyl groups, indoleamine 2,3-dioxygenase (IDO), tumor necrosis factor alfa (TNF-α), interleukin-6 (IL-6), interleukin-18 (IL-18) and C-reactive protein (CRP). Of the antioxidants and anti-inflammatory markers, superoxide dismutase (SOD), catalase, reduced glutathione (GSH), thioredoxin, and interleukin-10 (IL-10) levels were obtained.Results
Baseline levels of oxidation markers MDA, nitric oxide and protein carbonyl groups significantly decreased after three months on paricalcitol treatment, while levels of GSH, thioredoxin, catalase and SOD activity significantly increased. After paricalcitol treatment, levels of the inflammatory markers CRP, TNF-α, IL-6 and IL-18 were significantly reduced in serum and the level of anti-inflammatory cytokine IL-10 was increased.Conclusions
In renal patients undergoing hemodialysis, paricalcitol treatment significantly reduces oxidative stress and inflammation, two well known factors leading to cardiovascular damage.77.
78.
79.
IntroductionAcute general surgical units (AGSUs) are changing the way in which acute appendicitis is managed. In the AGSU at John Hunter Hospital, some patients wait more than 48 hours from admission to undergo an appendicectomy, usually because they are not unwell enough to precipitate an operation before that time. We analysed this subgroup of appendicectomy patients to determine how effectively they are being managed and how this might be improved.MethodsA retrospective review of prospectively collected data was conducted of all patients who received an appendicectomy while admitted under the AGSU at John Hunter Hospital in the five years between January 2009 and December 2013.ResultsA total of 1,039 appendicectomies were performed in the study period, with 81 patients (7.8%) waiting >48 hours for their operation (delayed appendicectomy group). Overall, the negative appendicectomy (NA) rate was 21.6%; the NA rate in delayed appendicectomies was 50.62% and a non-therapeutic operation occurred in 47% of this group (n=38). No significant difference was found in the incidence of perforation/gangrenous appendicitis between patients having surgery in <48 hours and the delayed appendicectomy groups (11.2% vs 9.9%, p=0.85). A combination of negative diagnostic imaging result, a normal white cell count and normal C-reactive protein (ie a negative ‘triple test’) was the best predictor of a negative appendicectomy (p=0.0158, negative predictive value: 0.91, 95% confidence interval: 0.59–0.99), in the delayed appendicectomy group.ConclusionsIn the delayed appendicectomy group, the incidence of perforation/gangrenous appendicitis was not significantly different from that found in patients having appendicectomy performed sooner. However, the NA and non-therapeutic operation rates were unacceptably high. An appendix triple test can improve diagnostic accuracy significantly without an unacceptable rise in the rates of perforation/gangrenous appendicitis. 相似文献
80.