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991.
本文报告4例外伤性迟发性脑内血肿。结合文献就本病的诊断标准、发生率和发病机理进行讨论。 相似文献
992.
肺表面活性物质蛋白质(8P)在肺表面活性物质(PS)的生理功能发挥中起着重要的作用。本文采用Sephadex LH-20柱层析分离纯化了牛肺PS,SDS-聚丙烯酰胺凝胶电泳分析SP分子量分别为30×10~3、10.37×10~3和5.08×10~3。并采用膜天平测定表面活性比较了含SP与不合SP的PS磷脂的生物活(忄牛),发现SP在PS吸附性、单分子膜形成性和稳定性中起着不可缺少的作用。 相似文献
993.
994.
BACKGROUND:
The FocalPoint Slide Profiler is an automated cervical cytology screening system that is approved for primary screening. It identifies up to 25% of slides as requiring No Further Review. However, few studies have evaluated FocalPoint performance with glandular abnormalities.METHODS:
Sixty‐six SurePath Papanicolaou (Pap) tests with a diagnosis of atypical glandular cells were identified. A total of 172 Pap tests with a diagnosis of “endometrial cells present” were included as controls. Follow‐up histology was abnormal if diagnosed as high‐grade squamous intraepithelial lesions, adenocarcinoma in situ, carcinoma, or complex endometrial hyperplasia. The FocalPoint software ranked each case into 1 of 7 categories: quintiles 1 (high risk) through 5 (low risk), No Further Review, and Process Review.RESULTS:
A total of 215 slides were qualified for review; 38 (57.6%) atypical glandular cells cases were abnormal on follow‐up biopsy, and 27 (71.1%) atypical glandular cells with abnormal follow‐up qualified for review; no cases were classified No Further Review, and 9 (33%) were ranked in quintile 1. Twenty‐three (82.1%) atypical glandular cells with benign follow‐up were qualified for review; 3 (11%) cases were classified No Further Review, and 4 (17%) were ranked in quintile 1. There was a statistically significant difference between the ranking of benign atypical glandular cells cases, abnormal atypical glandular cells cases, and control cases (P = .03). However, when collapsed into No Further Review versus all other quintiles, the differences were not significant (P = .20).CONCLUSIONS:
The FocalPoint Slide Profiler did not classify glandular lesions with abnormal follow‐up in the No Further Review category. However, these cases were not preferentially ranked in quintile 1. FocalPoint‐screened slides need to be carefully reviewed for glandular abnormalities, regardless of the quintile ranking. Cancer (Cancer Cytopathol) 2010. © 2010 American Cancer Society. 相似文献995.
Wing-Yee So Peter C. Tong Gary T. Ko Ronald C. Ma Risa Ozaki Alice P. Kong Xilin Yang Chung-Shun Ho Christopher C. Lam Juliana C. Chan 《Diabetes research and clinical practice》2009,86(2):89-95
Adiponectin is an adipocytokine with insulin sensitizing effect while chronic inflammation damages pancreatic β-cells leading to reduced insulin response. We aimed to prove the hypothesis that adiponectin levels and inflammatory markers (white blood cell counts [WCC], Helicobacter pylori [HP] titers, high sensitivity C-reactive protein [hs-CRP]) may interact to affect risk of diabetes. We studied 288 Chinese men (age-median: 41.0 years, IQR: 35.3–46.0 years) being recruited from the community in Hong Kong. The mean adiponectin level was 5.39 ± 2.81 μg/ml and 40.9% (n = 107) had low adiponectin level (<4 μg/ml). On multiple regression analysis, adiponectin was negatively associated with diabetes, HOMA insulin resistance top quartile, plasma glucose (PG) and 2 h insulin; and positively associated with HOMA insulin sensitivity index. WCC was independently associated with PG and 15′ insulin, and negatively associated with HOMA insulin sensitivity top quartile. HP titre was associated with 30′ PG level and diabetes. hs-CRP did not enter the multivariable model. In conclusion, adiponectin, WCC and HP titer are independent predictors for hyperglycemia and reduced insulin sensitivity in Chinese men. These findings may explain the high risk for diabetes in Chinese population despite their relatively low adiposity. 相似文献
996.
通过SoildWorks软件构建血液流场和8种不同结构裸支架(支架形状和通透率不同)的三维实体模型.利用计算流体力学方法,借助于有限元软件ANSYS 11.0对不同结构内支架分别置入血管后进行仿真研究.一定通透率范围内,对于半圆形截面支架模型血液从半圆面流向平面时的流阻大于反向流过时的流阻;通透率大到一定值时,结果相反.无论是网格状支架模型还是正弦状支架模型,血液从支架正反两个方向流过时的流阻大小随通透率的增加而减小;相同通透率下,血液从相同方向流过支架时,网格状支架模型的流阻比正弦状支架模型的大一些,大概在1.5倍左右.结果提示,血液从不同方向流过半圆形支架丝时的流阻存在一定的差异,这为支架结构设计提供了重要的理论指导意义. 相似文献
997.
OBJECTIVE: To investigate gamma-aminobutyric acid-ergic (GABAergic) innervation in the end-organs of human vestibule. METHODS: A modified pre-embedding immunostaining technique of immunoelectron microscopy were applied to accomplish this study with a polyclonal antibody to gamma-aminobutyric acid. RESULTS: GABA-immunoreactive products were confined to the nerve terminals, which were rich in synaptic vesicles and the non-myelinated fibers. The GABA-immunoreactive nerve fibers synapse with afferent calices surrounding the type I hair cells. CONCLUSION: This study shows that GABAergic fibers of human vestibular end-organs belong to the vestibular efferent system. 相似文献
998.
我院2005年6月-2010年3月,通过门诊及住院部排查及诊治先天性喉喘鸣11例,5例初诊诊断为支气管炎、3例诊断为支气管肺炎,现报告如下。 相似文献
999.
When a DNA probe hybridizes a DNA target and generates a G/A mismatch in the probe-target DNA heteroduplex, the mismatch enzyme, mutY, will cut the A base at the site of the mismatch. This specific cleavage at the mismatched A on the known probe will reveal the complementary DNA sequences of the targets. This study shows mismatch cleavage assays identify the complementary sequence of cryptic plasmid target in the extract of chlamydia infected cells in culture. In addition, the specific cleavage at a single base permits differentiation of two sequences with one base difference. This was shown in differentiating the subtypes of human immunodeficiency virus (HIV) type 1. The addition of amines in the assays increases the sensitivity by freeing the target for recycling. The combined assay system of high sensitivity and demonstrated specificity allows further evaluation for direct identification of pathogenic microorganisms in patient samples. 相似文献
1000.
Magnitude and time course of impaired primary haemostasis after stopping chronic low and medium dose aspirin in healthy volunteers 总被引:6,自引:2,他引:4
Aspirin ingestion within the previous 7-10 days is often considered a
relative contraindication to performing invasive procedures. However,
aspirin is an important component of many patients' treatment and
withholding therapy for this time may be dangerous. To measure both the
magnitude of the impairment in primary haemostasis induced by aspirin and
how much recovery of platelet function occurs within 48 h of stopping
aspirin, we studied serial changes in bleeding time (BT) in a randomized,
double-blind, placebo-controlled study. Fifty-two healthy volunteers had BT
performed before and at 2, 9, 24 and 48 h after a 7- day course of either
aspirin 75 mg, 300 mg or placebo. The main outcome recorded was BT at each
time. Nearly 25% of subjects had extended BT to more than 10 min, but no BT
were greater than 10 min, 48 h after stopping aspirin. There was a small
but statistically significant (P < 0.01) difference between the 48-h and
baseline BT in both aspirin groups (49 and 64 s in the 75 mg and 300 mg
groups, respectively). There was no difference in the magnitude or time
course of effect between low and medium dose aspirin (P = 0.392 and P =
0.797, respectively). We conclude that despite considerable
inter-individual variability in the magnitude of aspirin effect on primary
haemostasis, the time course of effect was consistent. In healthy
volunteers, the defect in primary haemostasis had largely disappeared 48 h
after the last dose.
相似文献