全文获取类型
收费全文 | 4501篇 |
免费 | 308篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 58篇 |
儿科学 | 110篇 |
妇产科学 | 67篇 |
基础医学 | 786篇 |
口腔科学 | 114篇 |
临床医学 | 426篇 |
内科学 | 813篇 |
皮肤病学 | 114篇 |
神经病学 | 645篇 |
特种医学 | 151篇 |
外科学 | 558篇 |
综合类 | 14篇 |
一般理论 | 2篇 |
预防医学 | 274篇 |
眼科学 | 101篇 |
药学 | 278篇 |
中国医学 | 8篇 |
肿瘤学 | 310篇 |
出版年
2024年 | 3篇 |
2023年 | 35篇 |
2022年 | 25篇 |
2021年 | 140篇 |
2020年 | 76篇 |
2019年 | 107篇 |
2018年 | 109篇 |
2017年 | 110篇 |
2016年 | 145篇 |
2015年 | 173篇 |
2014年 | 207篇 |
2013年 | 235篇 |
2012年 | 389篇 |
2011年 | 357篇 |
2010年 | 223篇 |
2009年 | 190篇 |
2008年 | 302篇 |
2007年 | 319篇 |
2006年 | 338篇 |
2005年 | 264篇 |
2004年 | 245篇 |
2003年 | 198篇 |
2002年 | 165篇 |
2001年 | 71篇 |
2000年 | 44篇 |
1999年 | 54篇 |
1998年 | 55篇 |
1997年 | 26篇 |
1996年 | 23篇 |
1995年 | 12篇 |
1994年 | 11篇 |
1993年 | 8篇 |
1992年 | 19篇 |
1991年 | 15篇 |
1990年 | 23篇 |
1989年 | 10篇 |
1988年 | 8篇 |
1987年 | 9篇 |
1986年 | 14篇 |
1985年 | 6篇 |
1984年 | 5篇 |
1983年 | 5篇 |
1977年 | 3篇 |
1976年 | 6篇 |
1973年 | 5篇 |
1971年 | 6篇 |
1968年 | 4篇 |
1967年 | 2篇 |
1966年 | 4篇 |
1965年 | 5篇 |
排序方式: 共有4829条查询结果,搜索用时 22 毫秒
61.
The compartment syndrome is an extremely rare complication after varicose vein surgery. If the early symptoms are not recognized and a treatment is not performed immediately most patients lose sensomotory function. Three cases with compartment syndrome after varicose vein stripping were the reason to point out the anatomy and pathophysiology of this complication and to explain the surgical technique. 相似文献
62.
Katrin Ergezinger J. Müller-Scholden K. Sandhage 《Monatsschrift für Kinderheilkunde》1998,146(8):758-760
Zusammenfassung
Für die Diagnose einer rheumatischen Valvulitis wird nach den revidierten Jones-Kriterien von 1992 ein pathologischer Auskultationsbefund
gefordert, der echokardiographische Befund einer Mitralklappeninsuffizienz wird nicht akzeptiert. Wir stellen eine Patientin
mit akutem rheumatischem Fieber vor, bei der sich neben einer Chorea minor keine weiteren Major- oder Minorsymptome fanden.
Allerdings konnte echokardiographisch neben einem Perikardergu? eine Mitralklappeninsuffizienz nachgewiesen werden.
Diskussion: Bei Patienten mit akutem rheumatischem Fieber wird eine Mitralklappeninsuffizienz ohne auskultatorisches Korrelat weitaus
h?ufiger als bei gesunden Kindern nachgewiesen und ist unter Anwendung strenger echokardiographischer Kriterien von physiologischen
Mitralklappenregurgitationen abgrenzbar. Da sich auch bei Patienten ohne klinische Zeichen einer Valvulitis nach langer Latenz
ein rheumatischer Herzfehler manifestieren kann, sollte – unter Anwendung strenger echokardiographischer Kriterien – der Nachweis
einer pathologischen Mitralklappeninsuffizienz in den Jones-Kriterien berücksichtigt werden.
相似文献
63.
Markus Grube Henriette Meyer Zu Schwabedissen Katrin Draber Damaris Pr?ger Klaus-Uwe M?ritz Knud Linnemann Christoph Fusch Gabriele Jedlitschky Heyo K Kroemer 《Drug metabolism and disposition》2005,33(1):31-37
L-carnitine is assumed to play an important role in fetal development, and there is evidence that carnitine is transported across the placenta. The protein involved in this transfer, however, has not been identified on a molecular level. We therefore characterized localization and function of the carnitine transporter OCTN2 in human placenta. Significant expression of OCTN2 mRNA was detected in human placenta applying real-time polymerase chain reaction technology. Confocal immunofluorescence microscopy using an antibody directed against the carboxy terminus of OCTN2 protein revealed that it is predominantly expressed in the apical membrane of syncytiotrophoblasts. This was confirmed by the costaining of organic anion-transporting polypeptide B and MRP2, which are known to be expressed mainly in the basal and apical syncytiotrophoblasts membrane, respectively. To further support this finding, we performed transport studies using basal and apical placenta membrane vesicles. We could demonstrate that the carnitine uptake into the apical vesicles was about eight times higher compared with the basal ones. Moreover, this uptake was sodium- and pH-dependent with an apparent K(m) value of 21 muM and inhibited by verapamil, which is in line with published data for recombinant OCTN2. Finally, experiments using trophoblasts in cell culture revealed that expression of OCTN2 paralleled human choriogonadotropin production and thus is modulated by cellular differentiation. In summary, we show expression and function of OCTN2 in human placenta. Moreover, several lines of evidence indicate that OCTN2 is localized in the apical membrane of syncytiotrophoblasts, thereby suggesting a major role in the uptake of carnitine during fetal development. 相似文献
64.
Katrin Trummal Külli T?nism?gi Ene Siigur Anu Aasp?llu Annika Lopp Tarvo Sillat Riste Saat Lagle Kasak Indrek Tammiste Priit Kogerman Nisse Kalkkinen Jüri Siigur 《Toxicon》2005,46(1):46-61
A novel endothelial cell apoptosis inducing metalloprotease (VLAIP) was found in the snake venom of Vipera lebetina. This metalloprotease is a heterodimeric glycoprotein with molecular mass of about 106 kDa. The protease hydrolyzes azocasein, fibrinogen and oxidized insulin B-chain. The enzyme readily hydrolyzes the Aalpha-chain and more slowly Bbeta-chain of fibrinogen. VLAIP does not cleave fibrin. The complete amino acid sequences of the two different monomers of VLAIP are deduced from the nucleotide sequences of cDNAs encoding these proteins. The full-length cDNA sequences of the VLAIP-A and VLAIP-B encode open reading frames of 616 and 614 amino acids that include signal peptide, propeptide and mature metalloproteinase with disintegrin-like and cysteine-rich domains. VLAIP belongs to the metalloprotease/disintegrin family of reprolysins and has high identity with the proteins that induce apoptosis of endothelial cells. Treatment of HUVEC cells with VLAIP induces changes in the attachment of cells to the substrate and causes cell death. We demonstrated that VLAIP inhibits endothelial cell adhesion to extracellular matrix proteins: fibrinogen, fibronectin, vitronectin, collagen I, and collagen IV. The induction of apoptosis by VLAIP was shown by means of a typical DNA fragmentation pattern of apoptotic cells as well as by monitoring phosphatidylserine externalization using annexin V-FITC staining and flow cytometric analysis. 相似文献
65.
Katrin Lamszus Marc A Brockmann Carmen Eckerich Peter Bohlen Chad May Ulrich Mangold Regina Fillbrandt Manfred Westphal 《Clinical cancer research》2005,11(13):4934-4940
PURPOSE: Inhibition of angiogenesis can influence tumor cell invasion and metastasis. We previously showed that blockade of vascular endothelial growth factor receptor-2 (VEGFR-2) with the monoclonal antibody DC101 inhibited intracerebral glioblastoma growth but caused increased tumor cell invasion along the preexistent vasculature. In the present study, we attempted to inhibit glioma cell invasion using a monoclonal antibody against the epidermal growth factor receptor (EGFR), which in the context of human glioblastomas, has been implicated in tumor cell invasion. In addition, we analyzed whether blockade of vascular endothelial (VE)-cadherin as a different antiangiogenic target could also inhibit glioblastoma angiogenesis and growth. EXPERIMENTAL DESIGNS: Nude mice who received intracerebral glioblastoma xenografts were treated using monoclonal antibodies against VEGFR-2 (DC101), EGFR (C225), and VE-cadherin (E4G10) either alone or in different combinations. RESULTS: Increased tumor cell invasion provoked by DC101 monotherapy was inhibited by 50% to 66% by combined treatment with C225 and DC101. C225 inhibited glioblastoma cell migration in vitro, but had no effect on the volume of the main tumor mass or on tumor cell proliferation or apoptosis in vivo, either alone or in combination with DC101. The anti-VE-cadherin monoclonal antibody E4G10 was a weaker inhibitor of tumor angiogenesis and growth than DC101, and also caused a weaker increase in tumor cell invasion. CONCLUSIONS: Inhibition of angiogenesis achieved by blocking either VEGFR-2 or VE-cadherin can cause increased glioma cell invasion in an orthotopic model. Increased tumor cell invasion induced by potent inhibition of angiogenesis with DC101 could be inhibited by simultaneous blockade of EGFR. 相似文献
66.
67.
68.
69.
TNFα and IL‐17A are differentially expressed in psoriasis‐like vs eczema‐like drug reactions to TNFα antagonists 下载免费PDF全文
70.
Whole‐body MR angiography: First experiences with the new TimCT technology with single contrast injection 下载免费PDF全文