The galea fascia flap in orbital reconstruction: innovative harvest technique.

AIM: To report the treatment of a recurrent adenoid-cystic carcinoma of the lacrimal gland required orbital exenteration with an en bloc resection of the lateral orbital rim and wall and an anterior portion of the temporal muscle. Reconstruction was planned with both the objectives of a shortened healing time for faster epithetic reconstruction and no visible scars. METHOD: After a cranially extended temporal approach, the dissection of the superficial galea layer was connected with the subcutaneous dissection of the upper and lower eyelid after subciliary incisions. RESULTS: Ample exposure of the temporal, frontal and orbital region was obtained, facilitating the orbital exenteration with en bloc resection of the lateral orbital rim and wall and the anterior portion of the temporal muscle. The epithelialization of the eye socket covered with the galea fascia flap was accelerated, providing faster epithetic reconstruction, without visible scars. CONCLUSIONS: Healing time is accelerated, providing faster epithetic rehabilitation without visible scars, which is important in the postoperative rehabilitation ladder after eye exenteration for both patient and surgeon. Further more ablative surgery within this region gets safer and easier due to the ample exposure of this innovative surgical technique. Further evaluation of the effectiveness and safety of this new approach is advisable.     

Cytotoxic lipid esters from Peucedanum ledebourielloides

Two cancer cell growth inhibitory esters, 1,2-dipalmitoyl-3-glucosyl glycerol (1) and 1,6-dihydroxy-hexane-bis-palmitoyl ester (2), together with arachidic acid-2-hydroxy-glycerol ester, daucosterol, and oleanolic acid, were isolated from the roots of Peucedanum ledebourielloides (Apiaceae family). The structures were determined by spectroscopic analyses. The esters 1 and 2 displayed significant activity against the SGC-7901, HT-29, and HL-60 cancer cell lines.     

类风湿关节炎伴发抑郁症动物模型的建立

目的：建立类风湿关节炎伴发抑郁症动物模型。方法：以复合造模思路，在采用胶原诱导复制大鼠类风湿关节炎模型基础上，结合孤养法和慢性不可预知的温和应激方法，造成类风湿关节炎伴发抑郁症动物模型。结果：造模后给予行为学测试和下丘脑5-HT、5-HIAA含量测定，模型组大鼠踝关节肿大畸形，关节炎指数增高，蔗糖水饮用量、旷野试验中水平及垂直得分、下丘脑5-HT、5-HIAA含量都明显小于正常组，有非常显著性差异（P〈0．01）。结论：类风湿关节炎伴发抑郁症动物模型关节肿大畸形，关节炎指数增高，呈抑郁状态，兴趣丧失，快感缺乏，运动迟滞等，能充分模拟类风湿关节炎伴发抑郁患者的核心症状，实验重复性较好，是研究类风湿关节炎伴发抑郁的理想模型。