全文获取类型
收费全文 | 195395篇 |
免费 | 9337篇 |
国内免费 | 2157篇 |
专业分类
耳鼻咽喉 | 3196篇 |
儿科学 | 6690篇 |
妇产科学 | 4711篇 |
基础医学 | 27056篇 |
口腔科学 | 5227篇 |
临床医学 | 16096篇 |
内科学 | 34941篇 |
皮肤病学 | 4880篇 |
神经病学 | 17173篇 |
特种医学 | 9655篇 |
外国民族医学 | 45篇 |
外科学 | 30785篇 |
综合类 | 5170篇 |
现状与发展 | 5篇 |
一般理论 | 38篇 |
预防医学 | 9843篇 |
眼科学 | 5204篇 |
药学 | 14413篇 |
23篇 | |
中国医学 | 1750篇 |
肿瘤学 | 9988篇 |
出版年
2023年 | 1188篇 |
2022年 | 1196篇 |
2021年 | 2690篇 |
2020年 | 2195篇 |
2019年 | 2228篇 |
2018年 | 3818篇 |
2017年 | 3264篇 |
2016年 | 4076篇 |
2015年 | 4876篇 |
2014年 | 5257篇 |
2013年 | 6683篇 |
2012年 | 10231篇 |
2011年 | 9846篇 |
2010年 | 5809篇 |
2009年 | 4629篇 |
2008年 | 9001篇 |
2007年 | 9752篇 |
2006年 | 9804篇 |
2005年 | 10194篇 |
2004年 | 9388篇 |
2003年 | 9120篇 |
2002年 | 8998篇 |
2001年 | 6728篇 |
2000年 | 6845篇 |
1999年 | 6087篇 |
1998年 | 1980篇 |
1997年 | 1690篇 |
1996年 | 1292篇 |
1995年 | 1069篇 |
1994年 | 940篇 |
1993年 | 848篇 |
1992年 | 2612篇 |
1991年 | 2493篇 |
1990年 | 2429篇 |
1989年 | 2272篇 |
1988年 | 1983篇 |
1987年 | 1964篇 |
1986年 | 1812篇 |
1985年 | 1735篇 |
1984年 | 1324篇 |
1983年 | 1054篇 |
1979年 | 1393篇 |
1978年 | 1021篇 |
1977年 | 855篇 |
1975年 | 1084篇 |
1974年 | 1123篇 |
1973年 | 1016篇 |
1972年 | 1026篇 |
1971年 | 1006篇 |
1970年 | 894篇 |
排序方式: 共有10000条查询结果,搜索用时 826 毫秒
11.
Notfall + Rettungsmedizin - 相似文献
12.
13.
14.
Y.R. Song B. Wu Y.T. Yang J. Chen L.J. Zhang Z.W. Zhang H.Y. Shi C.L. Huang J.X. Pan P. Xie 《Brazilian journal of medical and biological research》2015,48(11):973-982
Bipolar disorder (BD) is a common psychiatric mood disorder affecting more than 1-2%
of the general population of different European countries. Unfortunately, there is no
objective laboratory-based test to aid BD diagnosis or monitor its progression, and
little is known about the molecular basis of BD. Here, we performed a comparative
proteomic study to identify differentially expressed plasma proteins in various BD
mood states (depressed BD, manic BD, and euthymic BD) relative to healthy controls. A
total of 10 euthymic BD, 20 depressed BD, 15 manic BD, and 20 demographically matched
healthy control subjects were recruited. Seven high-abundance proteins were
immunodepleted in plasma samples from the 4 experimental groups, which were then
subjected to proteome-wide expression profiling by two-dimensional electrophoresis
and matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight tandem
mass spectrometry. Proteomic results were validated by immunoblotting and
bioinformatically analyzed using MetaCore. From a total of 32 proteins identified
with 1.5-fold changes in expression compared with healthy controls, 16 proteins were
perturbed in BD independent of mood state, while 16 proteins were specifically
associated with particular BD mood states. Two mood-independent differential
proteins, apolipoprotein (Apo) A1 and Apo L1, suggest that BD pathophysiology may be
associated with early perturbations in lipid metabolism. Moreover, down-regulation of
one mood-dependent protein, carbonic anhydrase 1 (CA-1), suggests it may be involved
in the pathophysiology of depressive episodes in BD. Thus, BD pathophysiology may be
associated with early perturbations in lipid metabolism that are independent of mood
state, while CA-1 may be involved in the pathophysiology of depressive episodes. 相似文献
15.
16.
17.
18.
Magon Stefano Pfister Armanda Laura Gaetano Lüthi Martin Papadopoulou Athina Kappos Ludwig Sprenger Till 《Brain imaging and behavior》2020,14(6):2159-2175
Brain Imaging and Behavior - Motor learning is a multi-stage process, in which the involvement of different brain regions is related to the specific stage. We aimed at characterising short... 相似文献
19.
20.
Peng Li Sha-Sha Tao Meng-Qin Zhao Jun Li Xiu Wang Hai-Feng Pan 《Immunological investigations》2015,44(7):603-615
Objective: Association of matrix metalloproteinases (MMPs) gene polymorphisms with rheumatoid arthritis is controversial. We conduct a meta-analysis to clarify this dispute.Methods: We systematically searched the electronic PUBMED, EMBASE and CNKI databases for research articles about MMPs (MMP-1, MMP-2, MMP-3, MMP-9) gene polymorphisms and rheumatoid arthritis (RA) up to January 2015. According to the heterogeneity, fixed-effects or random-effects models were used to calculate crude odds ratios (ORs) and 95% confidence intervals (95% CIs).Results: A total of 11 articles involving 2143 cases and 2049 controls were included in this meta-analysis. Overall, no significant associations were observed between MMP-1-1607 1G/2G polymorphism and RA. Stratification by ethnicity, no significant associations were observed in Caucasian populations. Similarly, no significant associations were observed between MMP-3-1171 5A/6A, MMP-9-1562 C/T polymorphisms and RA in overall and Caucasian populations, respectively. However, a weak association was found between MMP-2-1306 C/T polymorphism and RA (C vs. T, OR?=?0.813, 95%CI?=?0.694–0.953, p?=?0.010) in overall populations.Conclusions: The present meta-analysis suggests that MMP-1-1607 1G/2G, MMP-3-1171 5A/6A, MMP-9-1562 C/T polymorphisms are not associated with the susceptibility of RA, but MMP-2 -1306 C/T is weakly associated with susceptibility to RA. Further studies with more sample size are needed for definitive conclusions. 相似文献