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11.
Microarray analysis of senescent vascular smooth muscle cells: A link to atherosclerosis and vascular calcification 总被引:1,自引:0,他引:1
12.
Development of a Patient Decision Aid for Syncope in the Emergency Department: the SynDA Tool 下载免费PDF全文
Marc A. Probst MD MS Erik P. Hess MD MSc Maggie Breslin MDes Dominick L. Frosch PhD Benjamin C. Sun MD MPP Marie‐Noelle Langan MD Lynne D. Richardson MD 《Academic emergency medicine》2018,25(4):425-433
Objectives
The objective was to develop a patient decision aid (DA) to promote shared decision making (SDM) for stable, alert patients who present to the emergency department (ED) with syncope.Methods
Using input from patients, clinicians, and experts in the field of syncope, health care design, and SDM, we created a prototype of a paper‐based DA to engage patients in the disposition decision (admission vs. discharge) after an unremarkable ED evaluation for syncope. In phase 1, we conducted one‐on‐one semistructured exploratory interviews with 10 emergency physicians and 10 ED syncope patients. In phase 2, we conducted one‐on‐one directed interviews with 15 emergency care clinicians, five cardiologists, and 12 ED syncope patients to get detailed feedback on DA content and design. We iteratively modified the aid using feedback from each interviewee until clarity and usability had been optimized.Results
The 11 × 17‐inch, paper‐based DA, titled SynDA, includes four sections: 1) explanation of syncope, 2) explanation of future risks, 3) personalized 30‐day risk estimate, and 4) disposition options. The personalized risk estimate is calculated using a recently published syncope risk‐stratification tool. This risk estimate is stated in natural frequency and graphically displayed using a 100‐person color‐coded pictogram. Patient‐oriented questions are included to stimulate dialogue between patient and clinician. At the end of the development process, patient and physician participants expressed satisfaction with the clarity and usability of the DA.Conclusions
We iteratively developed an evidence‐based DA to facilitate SDM for alert syncope patients after an unremarkable ED evaluation. Further testing is required to determine its effects on patient care. This DA has the potential to improve care for syncope patients and promote patient‐centered care in emergency medicine.13.
An exploratory mixed‐methods crossover study comparing DVD‐ vs. Web‐based patient decision support in three conditions: The importance of patient perspectives 下载免费PDF全文
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Franchi Francesco Schneider David J. Prats Jayne Fan Weihong Rollini Fabiana Been Latonya Taatjes-Sommer Heidi S. Bhatt Deepak L. Deliargyris Efthymios N. Angiolillo Dominick J. 《Journal of thrombosis and thrombolysis》2022,54(3):373-381
Journal of Thrombosis and Thrombolysis - Low dose enteric-coated aspirin (EC-ASA) is routinely used for secondary cardiovascular event prevention. However, absorption of EC tablets is poor, which... 相似文献
15.
Dominick J. Laddy 《International reviews of immunology》2013,32(3-4):99-123
The field of DNA vaccine development began over 16 years ago with the observation that plasmid DNA could be injected into and expressed in vivo and drive adaptive immune responses. Since then, there has been great interest in developing this technology to create a new generation of vaccines with the ability to elicit both humoral and cellular immune responses from an inherently innocuous injection. However, DNA vaccines have yet to proceed past phase I/II clinical trials in humans – primarily due to a desire to induce more potent immune responses. This review will examine how DNA vaccines function to induce an immune response and how this information might be useful in future vaccine design. 相似文献
16.
Susan J Wilson Jonathan A Ward Helen M Pickett Simonetta Baldi Ana R Sousa Peter J Sterk Kian Fan Chung Ratko Djukanovic Barbro Dahlen Bo Billing Dominick Shaw Norbert Krug Thomas Sandstrӧm Christopher Brightling Peter H Howarth the U-BIOPRED consortium 《Clinical and experimental allergy》2021,51(2):296-304
17.
Rubinder Birk Dominick Shaw Cheika Kennedy Yutaro Higashi Roma Patel Ayushman Gupta Iain Au-Yong 《Current problems in diagnostic radiology》2021,50(5):656-661
PurposeCritically ill patients with coronavirus disease 2019 (COVID-19) are at increased risk of thrombosis. There are limited data on PE rates in COVID-19 patients at presentation to the emergency department (ED). In this study, we evaluated the detection rates of PE in patients presenting to the ED with suspected and proven COVID-19.MethodsA single-centre retrospective study was undertaken of 285 consecutive patients undergoing CT pulmonary angiogram (CTPA) in the Emergency Department at Nottingham University Hospitals NHS Trust in the United Kingdom between 25 March and 30 April 2020. At our institution, CTPA is performed in all patients undergoing CT for triage. The study group consisted of patients considered COVID-19 positive based on polymerase chain reaction (PCR) results and CTPA findings. The detection rate of PE in COVID-19 patients was compared to patients undergoing CTPA for suspected PE only and for suspected COVID-19 with no COVID CT findings and negative PCR (control group 1); and CTPAs prior to the coronavirus pandemic (control group 2).ResultsOne of 48 patients in the study group had a PE (2%) compared to 25/215 (12%) in control group 1 and 10/50 (20%) in control group 2. Prevalence of PE in the study group was lower than in control group 1 (P = 0.058) and compared to control group 2 (P = 0.005). Eleven patients undergoing CTPA had negative PCR but positive CT for COVID-19.ConclusionDetection rate of pulmonary embolus is low in patients with COVID-19 undergoing CTPA on a triage pathway. 相似文献
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Glyn Elwyn Isabelle Scholl Caroline Tietbohl Mala Mann Adrian GK Edwards Catharine Clay France Légaré Trudy van der Weijden Carmen L Lewis Richard M Wexler Dominick L Frosch 《BMC medical informatics and decision making》2013,13(Z2):S14