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991.
目的:观察宫颈癌同步放、化疗联合复方斑蝥胶囊的临床疗效。方法将经病理检测证实的宫颈鳞癌患者108例分为观察组54例(给予同步放、化疗联合复方斑蝥胶囊治疗)和对照组54例(给予单纯同步放、化疗治疗)。观察治疗后患者发生骨髓抑制、乏力及盗汗等放、化疗相关不良反应情况。结果观察组骨髓抑制、乏力、盗汗发生率分别为79.6%(43/54)、16.7%(9/54)、24.1%(13/54),对照组分别为96.3%(52/54)、64.8%(35/54)、55.6%(30/54),两组比较,差异均有统计学意义(χ2=7.083、25.926、11.167,P<0.05)。结论宫颈癌同步放、化疗联用复方斑蝥胶囊可有效减少不良反应的发生,保证治疗过程的顺利进行。 相似文献
992.
Kazuya Murata Yumi Abe Megumi Futamura-Masuda Akemi Uwaya Fumiyuki Isami Shixin Deng Hideaki Matsuda 《Journal of natural medicines》2014,68(3):498-504
The aim of this study was to investigate the effect of Morinda citrifolia fruit on blood fluidity. M. citrifolia fruit extract (MCF-ext) was investigated for its influence on blood aggregation and fibrinolysis. MCF-ext inhibited polybrene-induced erythrocyte aggregation and thrombin activity. The fibrinolytic activity of MCF-ext, in the euglobulin lysis time test and fibrin plate assay, is reported here for the first time. One of the active compounds was an iridoid glycoside, asperulosidic acid. The results indicated that MCF-ext is a potentially useful health food which is capable of improving blood flow and preventing lifestyle-related diseases. 相似文献
993.
De-Gang Xing Yan Zhang Gan-Jian Lin Yang-Yin Xie Shu-Yong Deng Hong-Liang Huang Guang-Bin Jiang Yun-Jun Liu 《Medicinal chemistry research》2014,23(10):4376-4382
A new Ru(II) complex [Ru(dmb)2(AHPIP)](ClO4)2 (Ru1) was synthesized and characterized by elemental analysis, electrospray ionization mass spectra, and 1H NMR and 13C NMR. The cytotoxicity in vitro toward BEL-7402, HeLa, MCF-7, and MG-63 cells was studied by MTT method. The complex shows moderate cytotoxic activity and the IC50 values are 20.2 (±1.6), 16.8 (±1.3), 39.9 (±2.5), and 46.7 (±2.0) μM toward BEL-7402, HeLa, MCF-7, and MG-63 cell lines, respectively. Apoptosis was studied by acridine orange/ethidium bromide staining and flow cytometry. The cellular uptake showed that the complex can enter into the cytoplasm. The cell cycle arrest showed that Ru1 inhibits the proliferation of BEL-7402 cells in the G0/G1 phase. In addition, the antioxidant activity of the complex against hydroxyl radical (·OH) was also investigated. 相似文献
994.
Qiao Deng Qing-Gang Ji Zhi-Qiang Ge Xiao-Fei liu Dan Yang Lv-Jiang Yuan 《Medicinal chemistry research》2014,23(12):5224-5236
A series of novel quinolin-2(1H)-one derivatives were synthesized and characterized by IR, 1H NMR, 13C NMR, and MS spectral data. All the new compounds were screened for their antimicrobial activities against six trains of bacteria and five fungi in vitro by twofold serial dilution technique. The bioactive assay showed that most of the compounds exhibited moderate to good antimicrobial activities in comparison with the streptomycin, especially, compound 6a, the fluoro-substituted aromatic amide derivative, showed good antibacterial activities against B.proteus and P.aeruginosa with minimal inhibitory concentration value of 32 and 16 μg/ml, respectively. 相似文献
995.
Peizhen Li Yueli Tian Honglin Zhai Fangfang Deng Meihong Xie Xiaoyun Zhang 《Medicinal chemistry research》2014,23(6):2869-2879
The development of EGFR kinase inhibitors attracts much attention of research for treating of cancer in recent years. In this work, based on a dataset composed of 46 EGFR kinase inhibitors, the combination of three-dimensional quantitative structure–activity relationship (3D-QSAR), molecular docking was applied to reveal structural characteristics impacting the inhibitory activity of EGFR, and to provide a better understanding of the binding modes between inhibitors and EGFR kinase. 3D-QSAR models of pyrazoline derivatives were established to reveal how steric, electrostatic, hydrophobic, and H-bond acceptor interactions contribute to inhibitors’ bioactivities, which were unanimous in the docking results. Furthermore, based on the most active compound, several new molecules with high inhibitory activity were obtained. 相似文献
996.
Qing-Gang Ji Dan Yang Qiao Deng Zhi-Qiang Ge Lv-Jiang Yuan 《Medicinal chemistry research》2014,23(5):2169-2177
A series of novel 1-methyl-3-substituted quinazoline-2,4-dione derivatives was designed, synthesized, and evaluated for their antimicrobial activities against six strains of bacteria and five fungi in vitro. The synthesized compounds were characterized by spectral methods. The bioactive assays showed that most of the compounds exhibited moderate antimicrobial activities against the tested strains. 相似文献
997.
目的:探讨骨瓜提取物致过敏性休克的临床特点及发生规律,为临床合理用药提供参考。方法:以“骨瓜提取物”、“休克”、“过敏反应”为关键词进行检索,对文献中的有关数据进行统计与分析。结果:检索到骨瓜提取物致过敏性休克文献29篇,病例36例。骨瓜提取物在近两年引起过敏性休克25例,占69.4%,75.0%的过敏性休克发生在首次用药过程中,66.7%发生在用药开始后的10 min内。结论:骨瓜提取物注射剂导致过敏性休克发生时间短,病情危重,应引起临床高度重视。 相似文献
998.
999.
目的:观察不同剂量糖皮质激素治疗眼带状疱疹的临床效果及安全性。方法:眼带状疱疹患者60例,随机分为两组,各30例,观察组采用强的松60mg qd,疗程7d。对照组采用强的松30mg qd,疗程7d。观察两组的水肿消退时间,疼痛减轻时间,3月后后遗症发生率及激素副作用。结果:两组患者水肿消退时间,疼痛减轻时间存在统计学差异。3月后后遗症发生率与激素副作用均无统计学差异。结论:较大剂量糖皮质激素在消除眼带状疱疹水肿及减轻疼痛方面优于小剂量糖皮质激素,未发现明显毒副作用,对后遗症的发生无明显影响。 相似文献
1000.
Zhiqiang Li Tianyong Hou Fei Luo Zhengqi Chang Xuehui Wu Junchao Xing Moyuan Deng Jianzhong Xu 《International orthopaedics》2014,38(11):2391-2398