排序方式: 共有46条查询结果,搜索用时 15 毫秒
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慢性肾功能衰竭是多种肾脏病晚期的严重综合症。笔者从7个方面,仅就所见资料进行了综述.以资临床参考借鉴。 相似文献
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本文对用于制备抗胃癌单抗的三种免疫流程进行了比较,并对所获得的单抗的选择性进行了评价。免疫流程Ⅰ以胃癌细胞系MGC 803为免疫原制备出单抗PD4。免疫流程Ⅱ采用胃癌细胞系M85以抗正常胃粘膜组织及混合淋巴细胞血清包被处理作为免疫原,制备出单抗 相似文献
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MONOCLONAL ANTIBODIES AGAINST HUMAN GASTRIC CANCER 总被引:1,自引:0,他引:1
Spleen cells from Balb/c mice immunized with five human gastric cancer cell lines in sequence were fused with murine myeloma cell line SP2/0, and hybridomas 3F4, 3G9 and 3H11, secreting monoclonal antibodiees (MoAbs) against gastric cancer, were obtained through selective culture and screening. These MoAbs have both good selectivity and a high positive rate of reaction for gastric cancer, reaching 5/5 and 84.8% to 93.5% for gastric cancer cells and tissues respectively. The reaction of MoAbs with normal cells and tissues was neglible.The corresponding antigens of the MoAbs were sensitive to digestion by trypsin and pronase and resistant to treatment with sodium periodate, indicating their nature as proteins. The antigen 3G9 could be visualized with Western blotting as two bands with molecular weights of 100KD and 70KD, however no band was found for antigens 3F4 and 3H11. There was a high expression of antigens in the majority of gastric cancer cells and tissues independent of his-topathological type of 相似文献
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胃癌单克隆抗体3H11的应用 总被引:2,自引:0,他引:2
胃癌单克隆抗体(McAb)3H11具有高阳性反应率、高选择性及高亲和力的特点.以~(131)I标记后注入荷胃癌裸鼠模型中,其瘤/肝比可达8.26±1.26,定位指数达6.08 ±1.51,ID%/g达11.00±2.62.该McAb与~(131)I偶联后可明显增强后者对肿瘤的杀伤效应及减低毒副反应.~(131)I标记的McAb 3H11静脉注入19例拟行手术的胃癌患者中,16例获阳性显像(84.2%).经胃镜引导注入癌旁粘膜下行胃癌放射免疫导向手术,判别胃壁肿瘤浸润的灵敏度、特异性及准确率分别为946%,967%及959%.判别淋巴结转移的上述指标分别为99.2%、97.7%及98.8%. 相似文献
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双特异性抗体介导胃癌杀伤效应的研究 总被引:1,自引:0,他引:1
为制备P210/MMC、P210/TNP及P40/CD3三种双特异性抗体(BsAb),采用不同技术路线进行细胞融合11次,接种7.484孔,生长1,111孔.双阳性孔为223,但仅获分泌BgAb的2次杂交瘤5株,可见BsAb的制备殊非易事。桥联法在确认BsAb的分泌性状时有重要意义.12株分泌γ及μ两种重链的三体杂交瘤,仅2株分BsAb,因此γ与μ形战组合的机率为167(2/12).BsAb(P210/TNP)带有“通用接头”,可介导多种TNP化的药物或毒素对胃癌靶细胞的杀伤效应。BsAb(P40/CD3)可介导外周血淋巴细胞(PBLs)对胃癌的杀伤效应,采用局部注射,4次冶疗可使移植胃癌全部消退,对临床试用有参考价值。 相似文献
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肿瘤相关杭原表达的异质性以及由之造成阴性表达的肿瘤细胞对导向杀伤的逃逸,是单克隆抗体(mAb)靶向治疗研究中的主要障碍之一。干扰素对某些肿瘤相关抗原表达可能有上调作用(up-regulation)。单克隆抗体的组合配伍(cocktail)可增加其对靶细胞的结合。本文拟由此途径提高mAbB靶向效应, 相似文献
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<正> 苏子降气汤出自《太平惠民和剂局方》由苏子、半夏、前胡、厚朴、肉桂、川当归、甘草、生姜、大枣、薄荷组成。其主要功效为降气平喘,温化寒痰。主治上实下虚之痰涎壅盛,喘咳短气,胸膈满闷等症。《医方集解》记载,一方内有沉香而无肉桂,治虚阳上浮之气不降,痰涎壅盛,咳嗽呕血等症。笔者临证有本方加减治疗凡属上盛下虚之证收到较好的效果。现述之于笔端,以便交流。 相似文献