铅对女工及其子代健康的影响

前言 五十年代以来,我国在铅对女工及其子代健康的影响研究方面作了一些工作。迄今,全国已发表论文75篇,共计调查了6,215人。其中包括1987年11月第一届全国妇女劳动卫生学术讨论会13篇、调查2,778人。按论文性质可分为综述性19篇、对女工健康影响9篇、对子代健康影响27篇、动物实验及细胞遗传毒性13篇。生     

Responses of CDKs and p53 in Delayed Ischemic Neuronal Death

Stroke is a debilitating disease that affects millions each year.While in many cases cerebral ischemic in jury can be limited by effectivw resuscitation or thrombolytic treatment,the injured neurons wither in a process known as delayed neuronal death(DND).Mounting evidence indicates that DND is not simply necrosis played out in slow motion but apoptosis is triggered.Of particular interest are two groups of signal proteins that participate in apoptosis-cyclin dependent kinases(CDKs) and p53-among a myriad of signaling events after an ischemic insult.Recent investigations have shown that CDKs,a family of enzymes initially known for their role in cell cycle regulation,are activated in injured neurons in DND.As for p53,new reports suggest that its up-regulation may represent a failed attempt to rescue in jured neurons,although its up-regulation was previously considered an indication of apoptosis.These observations thus rekindle an old quest to identify new neuroprotective targets to minimize the stroke damage.In this review,the author will examine the evidence that indicates the participation of CDKs and p53 in DND and then introduce pre-clinical data to explore CDK inhibition as a potential neuroprotective target.Finally,using CDK inhibition as an example,this paper will discuss the pertinent criteria for a viable neuroprotective strategy for ischemic in jury.     

从肾虚论治“幼稚子宫”一得

从肾虚论治“幼稚子宫”一得郝淑然河南医科大学第一附属医院（４５００５２）王桂枝河南省偃师市中医院（４７１９００）朱庸代河南医科大学第一附属医院（４５００５２）主题词性腺机能减退／中医药疗法“幼稚子宫”是指妇女在发育成熟期（１４～１８岁）以后，子宫发育...     

血清腺苷脱氨酶对肝脏疾病的诊断研究

本文肝病患者采用检测血清腺苷脱氨酶发现该酶在判断急性肝损伤及残存病病。协助诊断慢性肝病都优于ＡＬＴ，γ－ＧＴ，与正常人对照差异有显著性（Ｐ〈０．０１），提示ＡＤＡ对诊断各型肝病有诊断价值。     

冠心病患者65例院前急救及转归

冠心病患者６５例院前急救及转归０５００７１河北省人民医院急救中心甄胜西王学忠齐晓勇张国志急诊医学已成为一门独立新兴的边缘学科，院前急救是其首要的一环，是降低急诊死亡率之关键。诸多资料表明〔１～３〕，院前死亡占急诊死亡的４５％，冠心病猝死者约２／３死于...     

肠淋巴液对休克大鼠心肌特性的影响

大鼠重度失血性休克３０ｍｉｎ后，左心室内压的最大上升速率和左心室收缩压都显著下降，而左心室舒张末压却有所增高。说明心肌的收缩功能和舒张功能出现障碍，给少量淋巴液后使休克时下降的左心室内压的最大上升速率和左心室收缩压显著回升，而增的左心室舒张末压回落不明显，提示巴液改善休克心肌的收缩功能障碍，但对低血容量情况下的心肌舒功能无明显改善。     

胃癌单克隆抗体偶合物导向化疗的实验研究

胃癌单克隆抗体偶合物导向化疗的实验研究祝金泉王崇文张昆和谢勇胡伟（江西医学院消化内科研究所，南昌３３０００６）本文采用Ｂ淋巴细胞杂交瘤方法制备的鼠抗人胃癌单克隆抗体（代号８７１１Ｃ１ＭｃＡｂ），经盐析和ＤＥＡＥ－５２离子交换层析法纯化后，以Ｉｏｄｏｇ...     

PCR检测胃癌MCC,DCC基因和YNZ22位点串联重复序列的杂全…

为探讨抑基因杂合性丢失（ＬＯＨ）在胃癌发生、发展中作用，应用聚合酶链反应技术对４５例胃癌ＭＣＣ、ＤＣＣ基因和ＹＮＺ２２位点数量可变的串联重复序列（ＶＮＴＲ）区进行了分析。结果发现，胃癌ＭＣＣ基因ＬＨＯ率为３７．５％；ＤＣＣ为３３．３％；ＹＮＺ２２位点为５１．６％。ＬＯＨ与肿瘤大小、组织学分类、浸润深度、淋巴结转移无关。ＤＣＣ基因ＬＯＨ率在胃癌Ⅲ、Ⅳ期组显著高于Ⅰ、Ⅱ期组（１４．３％）。结果提示，Ｍ