Background: Reports of major and minor sequelae following lidocaine spinal anesthesia have generated interest in an alternative short-acting intrathecal agent. Of the available anesthetics suitable for short-duration spinal anesthesia, prilocaine is perhaps the most promising agent. However, data comparing the neurotoxicity of these agents are lacking. Accordingly, the present experiments investigate whether prilocaine and lidocaine differ with respect to sensory impairment and histologic damage when administered intrathecally in the rat.
Methods: Ninety rats were divided into three groups to receive an intrathecal infusion of 2.5% prilocaine in saline, 2.5% lidocaine in saline, or normal saline. The animals were assessed for persistent sensory impairment 4 days after anesthetic administration using the tail-flick test. Three days later, the animals were killed, and specimens of the spinal cord and nerve roots were obtained for histopathologic examination.
Results: Prilocaine and lidocaine produced equivalent elevations in tail-flick latency that differed significantly from saline. Histologic injury scores with prilocaine were greater than with lidocaine, but this difference did not reach statistical significance. 相似文献
Schistosomiasis'' japonica is one of the most important parasitic
diseases in China. Ever since its dscovery in this eountry (j) its
inCidenee、and extent Of enilemiCity haVe bec0删:e inCreaSlngIy evident
With imprOvement Of diagnoStiC methodS and a8 a reSUlt Of inVeStiga-
戗On8 made by VariOU8 W0rkerS. It iS Well knOWn that reglonS watered
by the Yan或ze RiVer were rampant w托h this di8ea8e. The vast areas
of endemlelty lnclude not only the territories im!mediately traversed by
the main stream and its lnnumerable tributarie8 but also districts adjaeent
to the mammoth bodies of water such as Great Lake(太湖),Poyanghu
t都防湖),and Tung七inghu(洞庭湖). Thus Kiangsu(江袜),、Chekiang
【浙江),Anhwei(安徽),Kiangsi(江西),Hupeh(湖北)and Hunan
(湖南) are the proVinees of high endemicity. Rampaney of the
infeStation dOes nOt, hoWever, COnfine to reglOnS of tbe Central and
lOWer YangtZe Valley aS eaSeS Of SChiStOSOmiaSiS have been reCOrded
il土the central plains Of Szechuan(四J”) (2—4)and sou¨thwest parC of
Chin可ihcluding Kwangsi(魔西)(5)and Yunnan(雷南)(艿。8). 相似文献
Sebrell in 1938 (i)五rst suspected that pellagra might be
a manifestation of multiple deficiency in which ribofiavin .might
play a role. Experiments carrie.d out by him and Butler in the
''same year showed that diets low in ribofiavin content would
produce a clinical syndrome, which we now know to'' be char-
acteristic of ribofiaviri. deficiency. The w~rk of these authors w.as
later confirmed by workers in all partbs of the world. Spies (2)i
Sydenstricker (3), Viakil(二), Gopalan (5), Hou (6), (7), etc.
a:re important contributors. The disease has been reported in
tIhe United States of America,''England, Africa, India, M.alaya
and is quite common in China, especially among soldiers, students,
coolies, refugees and prisoners. . 相似文献
INTRODUCTION
Feelings of discomfort may be experienced by persons entering
artificially cooled buildings in hot weather. For some years p4st,
residents in India, Mal.aya and notably in Shanghai have complained
that the cooling of public building,s by means of air-conditioning
syst;ems frequently fails to solve the problem of comfort during hot
weather. It is a common experience that an acute sense of chilling
descri''oed as "cold shock" may be felt on entering an air-conditioned
building from the street, whilst on leaving it an overpowering sensation
of heat may be encountered. 相似文献