盐酸氟西汀对帕金森病患者的早期应用

帕金森病是老年人群最常见的神经系统变性病之一.而抑郁症又是帕金森病后主要的急性和慢性并发症,干扰和阻碍了帕金森患神经功能障碍的康复过程,并影响其生活质量.氟西汀为5-HT再摄取抑制剂（SSRI）,是精神科首选的一线抗抑郁药,但需2～3周才能起效,故当发现抑郁症再抗抑郁治疗,往往会错过帕金森病患的最佳康复期.     

隐匿阴茎并尿道上裂1例分析

我们在2002-06月对1例隐匿阴茎合并尿道上裂患者行阴茎包皮旋转、切除纤维条索、尿道沟黏膜尿道成形术,效果满意,总结分析如下.     

葡萄糖利尿作用对输尿管结石CDFI超声诊断的价值

目的：探讨彩色多普勒超声（CDFI）对输尿管结石的诊断价值。方法：采用口服50％葡萄糖溶液20ml，软水300－500ml，于30分钟后施行常规断面超声加压探头扫查法。结果：460例输尿管结石，均经彩色多普勒超声（CDFI）、X线平片、静脉肾盂造影及逆行输尿管造影等检查确诊。超声符合率94．78％（436／460），经手术治疗176例及中西医结合治疗自然排石284例，均获满意疗效。结论：应用50％葡萄糖溶液利尿作用对输尿管结石的（CDFI）超声诊断，具有一定的临床应用价值。     

孤啡肽对大鼠离体心脏功能的调节作用及其对去甲肾上腺素诱发心脏功能变化的影响

Objective To investigate the effects of orphanin FQ (OFQ) on simple and norepinephrineactivated cardiac function in isolated rat heart.Methods Male SD rats aged 3-4 months weighing 250-280 g were anesthetized with intraperitoneal 25% urethane 1.4-1.8 ml.Their hearts were excised and passively perfused with K-H solutionin a Lanngendorff apparatus.A fluid-filled latex balloon was inserted into left ventricle for measurement of developed pressure.Left ventricular systolic pressure(LVSP),left ventricular end-diastofic pressure(LVEDP),left ventricular developed pressure(LVDP=LVSP-LVEDP),HR and±dp/dtmax were measured.Sixty isolated rat hearts were randomly divided into 10 groups(n=6 each):Ⅰ control group (group C);Ⅱ,Ⅲ,Ⅳ OFQ1,OFQ2,OFQ3 group--OFQ 10-6,10-7,10-8 mol/L were administered via perfusion system respectively;Ⅴ OFQ+UFP group--OFQ 10-6 mol/L+UFP-101 (all OFQ antagonist) 10-6 mol/L were administered;Ⅵ NE group--norepinephrine 10-5 mol/L;Ⅶ,Ⅷ,Ⅸ NE+OFQ groups--NE 10-5 mol/L+OFQ 10-6,10-7,10-8 mol/L were administered respectively;Ⅹ NE+OFQ+UFP group--NE 10-5 mol/L+OFQ 10-6mol/L+UFP-101 10-6mol/L.Results LVSP,LVDP and±dp/dtmax were significantly increased while HR was significantly decreased in the 3 OFQ groups as compared with control group.LVSP,LVDP±dp/dt max and HR were significantly increased in the 3 NE+OFQ groups as compared with NE group.Conclusion OFQ has positive inotropic action and negative chronotropic effect on the isolated rat heart.OFQ Can enhance the positive inotropic and chronotropic effect of NE on the heart.     

高频彩色多普勒超声诊断睾丸肿瘤的临床价值

目的探讨高频超声以及彩色多普勒血流(CDFI)显像技术诊断睾丸肿瘤的临床价值。方法回顾性分析经手术、病理检查证实的33例睾丸肿瘤的二维及CDFI声像图表现。结果 33例睾丸肿瘤的病理类型为精原细胞瘤16例,混合性生殖细胞瘤6例,胚胎癌7例,畸胎瘤3例,表皮样囊肿1例。其共同声像图表现为睾丸形态失常,体积增大,实质回声不均匀,可见大小不等的实性团块回声;不同病理类型的睾丸肿瘤有其各自的一些声像图特点。结论二维声像结合CDFI能对睾丸肿瘤良、恶性作出初步的诊断和鉴别诊断,具有较高的临床应用价值,为进一步治疗方案的制定提供依据,是睾丸肿瘤的首选影像学检查方法。     

坏死性筋膜炎早期诊断及治疗分析

目的 探讨坏死性筋膜炎的早期诊断及治疗,从而降低死亡率.方法 回顾性分析25例坏死性筋膜炎患者的临床资料.结果 25例患者,痊愈20例,死亡5例.结论 早期诊断及有效的治疗是治愈本病的关键.     

非小细胞肺癌循环肿瘤细胞的定量检测意义

Objective To investigate the sensitivity, specificity and clinical significance of detecting circulating tomor cells (CTCs) in NSCLC. Methods Twenty-five patients who undetwent surgical resection for NSCLC form Jan 2007 to Apr 2007 were in- cluded in this study. Control group included 10 patients with benign pulmonary diseses (2 case of hamartoma and 8 case of pulmonary tu berculosis) and 10 healthy volunteers. The pulmonary veins blood and peripheral vein blood were collected respectively. The CD326 immunomagnetic beads and CK-fluorescein isothiocyanate (CK-FITC) were served as the marker antibodies of CTCs. Firstly mononu- clear cell marked by minibeads conjugated with CD326, the mononuclear cells were enriched and separated though Magnetic-activated cell separation(MACS), then the positive separtion cells were marked by anti-CK-FTTC and anti-leukocyte antibody CD45-phyco- erythrine (anti-CD45-PE), finally those cells detected and analyzed by flow cytometry . Results For stage Ⅰ and stage Ⅱ patients (n= 16), CTCs were detected from peripheral vein blood of in 5 (5/16, 31.25%) and from pulmonary veins blood in 9 (9/16, 56.25%). For stage Ⅲ and stage Ⅳ, CTCs were detected from peripheral vein blood in 5 (5/9, 55.56%) and from pulmonary veins blood in 9(7/9,77.78%).For stage Ⅰ,CTCs were detected from peripheral vein blood in 3(3/13,23%)and from pulmo- nery veins blood in 8(8/13,61.54%).The whole CTCs positive detection rate from pilmonary veins blood was 64%(16/25)which higher than feom peripheral vein blood(40%,10/25)(P<0.05).Conclusion The method was set up by MACS combined with FCM to detect the CTCs of pulmonary veins blood and peripheral vein blood of patients.with NSCLC,MACS combined with FCM may improve detection rate of CTCs.This technique appears to be an efficient to detect circulating tumor cells and may be important for dinical practice in the future.     

膝关节骨挫伤的MRI诊断价值

骨挫伤是外伤后骨的隐匿性损伤,临床表现缺乏特异性,主要表现为关节附近疼痛、肿胀、活动受限。X线及CT等传统影像学在骨挫伤的诊断方面存在局限性,明确诊断需依靠MRI检查。骨挫伤多发生在长骨的干骺部或骨端,常见于膝关节的股骨髁及胫骨平台,并且多数合并韧带或半月板损伤。本文总结我院经临床和MRI诊断的骨挫伤病人45例,探讨MRI在骨挫伤诊断中的应用价值,提高对骨挫伤的认识。     

小剂量多巴胺在肾缺血-再灌注损伤中的抗损伤作用

目的 探讨多巴胺在抗肾缺血-再灌注中损伤中的作用及其可能的作用机制.方法 选取体质量(2.1±0.2)kg的日本大耳白兔23只,随机分为生理盐水对照组(n=11)和多巴胺组(n=12),采用双盲法,通过夹闭家兔肾动脉的方式建立肾缺血模型,两组家兔在实验过程中分别持续静滴生理盐水或多巴胺1.5～2μg/(kg·min).分别于夹闭肾动脉前和缺血50 min再灌注30 min后取家兔肾静脉血,检测血肌酐(Scr)、血尿素氮(BUN)和丙二醛(MDA),并记录缺血再灌注前后的尿量.结果 两组血肌酐、血尿素氮和丙二醛在再灌注后较夹闭前均明显升高(P<0.05);再灌注30 min后对照组各指标升高更明显(P<0.05),而尿量无明显统计学差异(P>0.05).结论 小剂量多巴胺对肾缺血-再灌注损伤具有抗损伤保护作用,其作用机制可能与抗氧化作用有关.