人参二醇对鱼藤酮MPP＋诱导的BV2细胞活性下降的作用

目的观察人参二醇对鱼藤酮、MPP＋诱导的小鼠小胶质细胞活性下降的影响。方法以小鼠BV2细胞为研究对象,以鱼藤酮（0．03、0．1、0．3、1、3μmol／L）或MPP＋（10、30、100、300、1000μmol／L）处理24h和诱导细胞活性下降。设阴性对照组、人参二醇对照组（100mg／L）,鱼藤酮（0．1μmol／L）或MPP＋（100μmol／L）损伤组,人参二醇治疗组（10、25、50、75、100mg／L）。采用MTT法检测细胞活性。结果各浓度人参二醇对BV2细胞的活性无明显影响。鱼藤酮或MPP＋处理24h可诱导BV2细胞活性下降,各浓度人参二醇不能逆转鱼藤酮或MPP＋造成的细胞活性下降。结论人参二醇对鱼藤酮或MPP＋诱导的BV2细胞活性下降无保护作用。     

内外联动探索引才机制创新 对话厦门市卫生局局长杨叔禹

正强化人才优先战略,这是杨叔禹一直倡导的。从临床专家到职业院长,再到区域卫生的规划者和决策者,厦门市卫生局局长杨叔禹秉持了制度创新、机制创新、服务创新的理念,坚持以需求和学科建设为导向,以引进和培养并重为抓手,以高端人才、基层人才、管理人才为重点的发展思路。     

曾益新:建立中国医生的国家标准

正医院里,时常能听到患者抱怨:"你们大医院人太多,排队排一上午,医生却只看几分钟,我们如果去乡镇医院,医生能看好久呢。"有人说:"那你怎么不去呢?"患者不好意思了:"不是这里看的好嘛,担心地方看不了啊。"     

聚焦首届中国卫生论坛

当下开展的深化医药卫生体制改革，作为30年卫生改革的延续和深化，更要以前一阶段的改革作为基础，总结以往的经验教训，进一步摆正价值取向。     

健康

性格外向有助长寿，运动前不宜吃香蕉和巧克力，阿司匹林或增加脑微出血风险     

骨盆骨肉瘤的外科治疗策略探讨

Objectives To investigate the clinical outcome of consecutive pelvic osteosarcoma treated with surgery and chemotherapy in a single institution, and to discuss the surgical strategy, resection and reconstruction. Methods Twenty-one consecutive cases with pelvic osteosarcoma underwent surgical procedures between June 2000 and June 2009. There were 12 male and 9 female with a mean age of 32 years. According to Enneking and Dunham pelvic classification system, type I was 3 cases, type I + IV 3 cases,type I + Ⅱ 4 cases,type Ⅱ + Ⅲ 4 cases,type I + Ⅱ + Ⅲ 1 case,type Ⅲ 1 case,and type I + Ⅱ + Ⅳ 5 cases. Among the 21 cases, 19 were diagnosed as classical osteosarcoma and 2 were diagnosed as low-grade pathologically. All the tumors were stage Ⅱ B. All the patients received en-bloc resection with 13 wide resection and 8 marginal resection. Thirteen patients underwent modular hemipelvic endoprosthesis reconstruction, and 5 patients underwent rod-screw system reconstruction combined with autograft. Two patients received hemipelvectomy and one type Ⅲ patients had resection without reconstruction. The mean follow-up period was 30. 3 months (range,6. 0-87. 0). Results Thirteen patients out of 21 survived after treatment The overall survival rate was 61. 9% , and 23. 8% patients were alive without disease. The estimated 5-year survival rate was 44. 2% based on Kaplan-Meier curve. The local recurrence rate was 28.6% , among which 4 cases were type Ⅱ resection, 1 was type I resection, 1 was type I + Ⅳ resection. No local relapse was found on the hemipelvectomy and type Ⅲ resection cases. The local recurrence rate after wide resection was 23. 1% ,and 37. 5% for marginal resection. Nine patients had lung metastases and one patient was found bone and lymph node metastases. The MSTS 93 function score was 20. 6±5. 4 for 13 patients,and 22. 5±2. 1 for rod-screw reconstruction cases. The function score was 17. 7±5. 5 for hemipelvic prosthetic reconstruction. Conclusion Limb salvage procedures could be performed on most pelvic osteosarcoma cases, and satisfying function outcome could be achieved with proper reconstruction,however,the overall survival is still lower compared with those in extremities.     

追踪《护士条例》施行一周年

对于中国正在快速发展的护理事业来说，为护士立法，使她们的权利有了法律的支持和保障只是个开始。将不断涌现的现实问题在执行层面及时调整和解决，使相关条款在现行的医疗体制下落到实处，才是百万护士所殷切希望的。     

我国首次开展国际护士执业水平考试

11月11日，国际护士执业水平考试（International Standards Programfor Professional Nurses，ISPN）在我国首次开考。48名考生分别在北京、上海、沈阳参加了考试。     

为利贫卫生政策制定服务——访HPSP知识管理领域负责人高军

《中国卫生人才》：知识管理在国际上是一个很新的概念。能否请您具体介绍一下知识管理的概念、起源和应用情况，以及从国际经验看，知识管理如何服务于卫生政策制定？