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351.
Jrmie Sellam Sandrine Marion‐Thore Florent Dumont Sbastien Jacques Henri‐Jean Garchon Stphanie Rouanet Yassine Taoufik Houria Hendel‐Chavez Jean Sibilia Jacques Tebib Xavier Le Loët Bernard Combe Maxime Dougados Xavier Mariette Gilles Chiocchia 《Arthritis \u0026amp; Rheumatology》2014,66(8):2015-2025
352.
El Hassani Y Fournet M Momjian S Pollo C Seeck M Pegna A Schaller K 《Acta neurochirurgica》2012,154(8):1337-1342
Background
The neuropsychological results of temporal lobe epilepsy surgery are well reported in the literature. The aim of this study was to analyse the neuropsychological outcome in a consecutive series of patients with extra-temporal epilepsy.Methods
We retrospectively analysed the data of patients operated between 1996 and 2008 for extra-temporal epilepsy. Standard neuropsychological tests were applied. We assessed the neuropsychological outcome after surgery and the correlation of the neuropsychological outcome with (1) side and localisation of surgery, (2) Engel scale for seizure outcome and (3) timing of surgery.Findings
Patients had a better neuropsychological outcome when undergoing non-frontal resection [χ2 (2) =6.66, p?=?0.036]. Subjects who had undergone left or right resection showed no difference in outcome [χ2 (2) =0.533, p?=?0.766]. The correlation between the Engel scale for seizure re-occurence and the neuropsychological scores showed only a tendency for better outcome (Spearman ρ?=??0.437; p?=?0.069). The global measure of change did not correlate significantly with delay of surgery (Spearman ρ?=??0.163; p?=?0.518).Conclusions
Resective epilepsy surgery improves neuropsychological status outcome in patients with extra-temporal epilepsy even if the patient did not become seizure free. The outcome is better for non-frontal localisation.353.
Spyros Pournaras Aggeliki Poulou Konstantina Dafopoulou Yassine Nait Chabane Ioulia Kristo Demosthenes Makris Julie Hardouin Pascal Cosette Athanassios Tsakris Emmanuelle Dé 《Antimicrobial agents and chemotherapy》2014,58(2):828-832
Two colistin-susceptible/colistin-resistant (Cols/Colr) pairs of Acinetobacter baumannii strains assigned to international clone 2, which is prevalent worldwide, were sequentially recovered from two patients after prolonged colistin administration. Compared with the respective Cols isolates (Ab248 and Ab299, both having a colistin MIC of 0.5 μg/ml), both Colr isolates (Ab249 and Ab347, with colistin MICs of 128 and 32 μg/ml, respectively) significantly overexpressed pmrCAB genes, had single-amino-acid shifts in the PmrB protein, and exhibited significantly slower growth. The Colr isolate Ab347, tested by proteomic analysis in comparison with its Cols counterpart Ab299, underexpressed the proteins CsuA/B and C from the csu operon (which is necessary for biofilm formation). This isolate also underexpressed aconitase B and different enzymes involved in the oxidative stress response (KatE catalase, superoxide dismutase, and alkyl hydroperoxide reductase), suggesting a reduced response to reactive oxygen species (ROS) and, consequently, impaired colistin-mediated cell death through hydroxyl radical production. Cols isolates that were indistinguishable by macrorestriction analysis from Ab299 caused six sequential bloodstream infections, and isolates indistinguishable from Ab248 caused severe soft tissue infection, while Colr isolates indistinguishable from Ab347 and Ab249 were mainly colonizers. In particular, a Cols isolate identical to Ab299 was still invading the bloodstream 90 days after the colonization of this patient by Colr isolates. These observations indicate considerably lower invasiveness of A. baumannii clinical isolates following the development of colistin resistance. 相似文献
354.
355.
G Laurent S Saal MY Amarouch DM Béziau RF Marsman L Faivre J Barc C Dina G Bertaux O Barthez C Thauvin-Robinet P Charron V Fressart A Maltret E Villain E Baron J Mérot R Turpault Y Coudière F Charpentier JJ Schott G Loussouarn AA Wilde JE Wolf I Baró F Kyndt V Probst 《Journal of the American College of Cardiology》2012,60(2):144-156
356.
357.
With the continued development of non-toxic photosensitizer drugs, interstitial photodynamic therapy (iPDT) is showing more favorable outcomes in recent clinical trials. IPDT planning is crucial to further increase the treatment efficacy. However, it remains a major challenge to generate a high-quality, patient-specific plan due to uncertainty in tissue optical properties (OPs), µa and µs. These parameters govern how light propagates inside tissues, and any deviation from the planning-assumed values during treatment could significantly affect the treatment outcome. In this work, we increase the robustness of iPDT against OP variations by using machine learning models to recover the patient-specific OPs from light dosimetry measurements and then re-optimizing the diffusers’ optical powers to adapt to these OPs in real time. Simulations on virtual brain tumor models show that reoptimizing the power allocation with the recovered OPs significantly reduces uncertainty in the predicted light dosimetry for all tissues involved. 相似文献
358.
Roger A. Fielding Donato Rivas Gregory J. Grosicki Yassine Ezzyat Lisa Ceglia Lori Lyn Price Cemal Orhan Kazim Sahin Kelli Fowler Tyler White Shane Durkee Katja Kritsch Aouatef Bellamine 《Nutrients》2021,13(11)
The primary objective of this study was to investigate the potential synergy between low doses of L-carnitine tartrate and creatine monohydrate to induce muscle protein synthesis and anabolic pathway activation in primary human myoblasts. In addition, the effects of Lipid multi-particulates (LMP) formulation on creatine stability and bioavailability were assessed in rodents and healthy human subjects. When used individually, L-carnitine tartrate at 50 µM and creatine monohydrate at 0.5 µM did not affect myoblast protein synthesis and signaling. However, when combined, they led to a significant increase in protein synthesis. Increased AKT and RPS6 phosphorylation were observed with 50 µM L-carnitine tartrate 5 µM creatine in combination in primary human myoblasts. When Wistar rats were administered creatine with LMP formulation at either 21 or 51 mg/kg, bioavailability was increased by 27% based on the increase in the area under the curve (AUC) at a 51 mg/kg dose compared to without LMP formulation. Tmax and Cmax were unchanged. Finally, in human subjects, a combination of LMP formulated L-carnitine at 500 mg (from L-carnitine tartrate) with LMP formulated creatine at 100, 200, or 500 mg revealed a significant and dose-dependent increase in plasma creatine concentrations. Serum total L-carnitine levels rose in a similar manner in the three combinations. These results suggest that a combination of low doses of L-carnitine tartrate and creatine monohydrate may lead to a significant and synergistic enhancement of muscle protein synthesis and activation of anabolic signaling. In addition, the LMP formulation of creatine improved its bioavailability. L-carnitine at 500 mg and LMP-formulated creatine at 200 or 500 mg may be useful for future clinical trials to evaluate the effects on muscle protein synthesis. 相似文献
359.
Amine Bouchlarhem Leila Haddar Oussama Lamzouri Onci-Es-Saad Siham Nasri Narjisse Aichouni Houssam Bkiyar Yassine Mebrouk Imane Skiker Brahim Housni 《Radiology Case Reports》2021,16(11):3602
Since the introduction of tyrosine kinase inhibitors as primary therapy for patients with chronic myeloid leukemia (CML), the prognosis of these patients has improved significantly, and the number of patients who progress to the blast phase has decreased considerably. We report the case of a 35 year-old CML patient in accelerated phase treated with nilotinib, who presents a severe COVID-19 infection requiring non-invasive ventilation, and who subsequently presents a multiple cranial nerve palsy revealing a blast crisis of his CML. Multiple cranial nerve palsy is a sign of neurological involvement of CML in its blast phase. The blast crisis represents a real challenge for the clinician, especially during COVID-19 infection. The treatment remains the association of a tyrosine kinase inhibitors with a chemotherapy protocol, as well as the administration of methotrexate and cytarabine by intrathecal and intravenous infusion in high doses. Despite the importance of the association of CML with COVID-19 infection, there is not yet enough data to know the true impact of this infection on the evolution of this hemopathy. 相似文献
360.
Hazem Beji Mohamed Fadhel Chtourou Slim Zribi Yassine Kallel Mahdi Bouassida Hassen Touinsi 《World Journal of Clinical Cases》2023,11(9):2116-2118
The present letter to the editor is related to the work entitled “Large leiomyoma of lower esophagus diagnosed by endoscopic ultrasonography-fine needle aspiration: A case report.” Although endoscopic ultrasonography seems necessary in a suspected leiomyoma of the esophagus, the performance of biopsies via fine needle aspiration is controversial as it increases the risk of complications such as bleeding, infection, and intraoperative perforations. Laparoscopy is the best treatment strategy for small tumors. Laparotomy with tumor enucleation or esophageal resection can be considered in large leiomyomas. 相似文献