全文获取类型
收费全文 | 1524篇 |
免费 | 88篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 96篇 |
妇产科学 | 15篇 |
基础医学 | 170篇 |
口腔科学 | 29篇 |
临床医学 | 101篇 |
内科学 | 445篇 |
皮肤病学 | 29篇 |
神经病学 | 96篇 |
特种医学 | 37篇 |
外科学 | 270篇 |
综合类 | 5篇 |
预防医学 | 23篇 |
眼科学 | 1篇 |
药学 | 101篇 |
中国医学 | 4篇 |
肿瘤学 | 187篇 |
出版年
2023年 | 8篇 |
2021年 | 29篇 |
2020年 | 15篇 |
2019年 | 31篇 |
2018年 | 26篇 |
2017年 | 27篇 |
2016年 | 36篇 |
2015年 | 39篇 |
2014年 | 57篇 |
2013年 | 56篇 |
2012年 | 92篇 |
2011年 | 77篇 |
2010年 | 49篇 |
2009年 | 49篇 |
2008年 | 78篇 |
2007年 | 109篇 |
2006年 | 122篇 |
2005年 | 82篇 |
2004年 | 75篇 |
2003年 | 79篇 |
2002年 | 78篇 |
2001年 | 20篇 |
2000年 | 15篇 |
1999年 | 21篇 |
1998年 | 31篇 |
1997年 | 44篇 |
1996年 | 33篇 |
1995年 | 24篇 |
1994年 | 24篇 |
1993年 | 24篇 |
1992年 | 19篇 |
1991年 | 10篇 |
1990年 | 11篇 |
1989年 | 8篇 |
1988年 | 7篇 |
1987年 | 7篇 |
1986年 | 6篇 |
1985年 | 10篇 |
1984年 | 4篇 |
1983年 | 5篇 |
1981年 | 4篇 |
1980年 | 4篇 |
1979年 | 5篇 |
1978年 | 5篇 |
1958年 | 18篇 |
1957年 | 8篇 |
1956年 | 10篇 |
1955年 | 4篇 |
1954年 | 6篇 |
1940年 | 2篇 |
排序方式: 共有1622条查询结果,搜索用时 312 毫秒
51.
Yoshinobu Yanagi Hidenobu Matsuzaki Naoki Katase Tomoo Onoda Marina Hara Teruhisa Unetsubo Hitoshi Nagatsuka Jun-ichi Asaumi 《Oral Radiology》2012,28(2):157-165
Adenoid cystic carcinoma (ACC) of the head and neck region is an uncommon epithelial tumor of the major and minor salivary glands. In the oral region, although ACC arising from the minor salivary glands is the second most commonly found tumor in the tongue base, its occurrence in the anterior part of the tongue is rare. Histopathologically, ACC is categorized into three growth patterns (tubular, cribriform, and solid types) and three histologic grades (I?CIII) that are based on the proportions of these patterns. According to this classification, tubular- and cribriform-type ACCs are considered to be lower grade lesions, while solid-type ACCs are considered to be higher grade lesions. A fourth histopathological type has recently been reported by some authors, namely, dedifferentiation or high-grade transformation of ACC. However, very few studies have focused on the imaging features of these ACCs. We report here the case of a 63-year-old female patient with ACC of the tongue with dedifferentiated components, together with the radiological images and pathological features of this ACC. 相似文献
52.
Tomoko Katsui Taniyama Chigusa Morizane Kohei Nakachi Satoshi Nara Hideki Ueno Shunsuke Kondo Tomoo Kosuge Kazuaki Shimada Minoru Esaki Masafumi Ikeda Shuichi Mitsunaga Taira Kinoshita Masaru Konishi Shinichiro Takahashi Takuji Okusaka 《Pancreatology》2012,12(5):428-433
ObjectivesA global consensus on how to treat recurrent pancreatic cancer after adjuvant chemotherapy with gemcitabine (ADJ-GEM) does not exist.MethodsWe retrospectively reviewed the clinical data of 41 patients with recurrences who were subsequently treated with chemotherapy.ResultsThe patients were divided into two groups according to the time until recurrence after the completion of ADJ-GEM (ADJ-Rec): patients with an ADJ-Rec < 6 months (n = 25) and those with an ADJ-Rec ≥ 6 months (n = 16). The disease control rate, the progression-free survival after treatment for recurrence and the overall survival after recurrence for these two groups were 68 and 94% (P = 0.066), 5.5 and 8.2 months (P = 0.186), and 13.7 and 19.8 months (P = 0.009), respectively. Furthermore, we divided the patients with an ADJ-Rec < 6 months into two groups: patients treated with gemcitabine (n = 6) and those treated with alternative regimens including fluoropyrimidine-containing regimens (n = 19) for recurrent disease. Patients treated with the alternative regimens had a better outcome than those treated with gemcitabine.ConclusionsFluoropyrimidine-containing regimens may be a reasonable strategy for recurrent disease after ADJ-GEM and an ADJ-Rec < 6 months. 相似文献
53.
Seiji Oguro Kazuaki Shimada Yoji Kishi Satoshi Nara Minoru Esaki Tomoo Kosuge 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2013,398(4):531-538
Purpose
Although a pancreaticoduodenectomy (PD) has been recently regarded as a safe surgical procedure at high-volume centers, the efficacy of PD for patients 80 years of age and older is controversial. The aim of this study was to evaluate the perioperative and long-term outcomes following PD in patients 80 years of age and older.Methods
Elderly patients 80 years of age and older who underwent PD between 2001 and 2009 were identified. The perioperative and long-term outcomes were compared with patients younger than 80 years of age.Results
Of 561 total patients, 22 patients (3.9 %) were 80 years of age or older. Mortality occurred in one patient (4.5 %). Postoperative major complications (Clavien–Dindo classification ≥grade III) occurred in six patients (27.3 %) in this group, which was significantly higher than in patients younger than 80 years of age (P?=?0.008). The survival of the elderly patients undergoing PD for pancreatic cancer was significantly shorter than that for the same patient group with other diseases (median survival, 13 versus 82 months; P?=?0.014). Only one elderly patient with pancreatic cancer survived more than 3 years.Conclusions
PD for pancreatic cancer in patients aged 80 and older should be carefully selected, because it is associated with a higher incidence of severe postoperative complications and a small change of long-term survival. 相似文献54.
55.
Arata Tsutsumida Yuhei Yamamoto Mitsuru Sekido Tomoo Itoh 《Journal of plastic surgery and hand surgery》2013,47(2):105-107
A patient presented with malignant melanoma of the parotid gland with no obvious primary lesions, which was treated by total parotidectomy with excision of skin. Despite radiotherapy for brain metastases and combination chemotherapy for lung and lymph node metastases, she died 13 months after the initial operation. 相似文献
56.
Makoto Uchino Satoshi Yamashita Katsuhisa Uchino Akira Mori Akio Hara Tomohiro Suga Tomoo Hirahara Tatsuya Koide En Kimura Taro Yamashita Akihiko Ueda Ryoichi Kurisaki Junko Suzuki Shoji Honda Yasushi Maeda Teruyuki Hirano Yukio Ando 《Clinical neurology and neurosurgery》2013
Objective
The characteristic pathological muscular findings of polymyositis (PM) and dermatomyositis (DM) have been shown to reflect their different pathogeneses. Here, we characterized the muscle biopsy findings of PM and DM patients with or without malignancy.Methods
We evaluated the muscle biopsy findings of 215 consecutive PM and DM patients admitted to our hospital between 1970 and 2009. Pathology of the lesion biopsy sections was classified into 3 types: endomysial infiltration-type, perivascular infiltration-type, and rare-infiltrative-type.Results
There was no difference between the muscle pathology of PM patients with and without malignancy. However, the incidence of rare-infiltrative type muscle pathology in DM patients with malignancy was significantly higher than in those without such tumors (p = 0.0345).Conclusion
The incidence of rare-infiltrative type muscle pathology may be a predictive marker of DM with malignancy. 相似文献57.
58.
59.
Yoshihiro Sakamoto Shutaro Hori Seiji Oguro Junichi Arita Yoji Kishi Satoshi Nara Minoru Esaki Akio Saiura Kazuaki Shimada Takeharu Yamanaka Tomoo Kosuge 《Journal of gastrointestinal surgery》2016,20(3):595-603
Background
A retrospective analysis indicated that the incidence of delayed gastric emptying (DGE) was less after using a circular stapler (CS) for duodenojejunostomy than that after hand-sewn (HS) anastomosis in pylorus-preserving pancreaticoduodenectomy (PpPD). This randomized clinical trial compared the incidence of DGE postoperative after CS duodenojejunostomy with that of conventional HS anastomosis in PpPD.Methods
We randomly assigned 101 patients (age 20–80) undergoing PpPD to receive CS duodenojejunostomy (group CS, n?=?50) or HS duodenojejunostomy (group HS, n?=?51) in two Japanese cancer center hospitals between 2011 and 2013. The patients were stratified by institution and size of the main pancreatic duct (<3 or ≥3 mm). The primary endpoint was the incidence of grade B or C DGE according to the international definition with a non-inferiority margin of 5 %. This trial is registered with University hospital Medical Information Network (UMIN) Center: UMIN000005463.Results
Per-protocol analysis of data on 95 patients showed that grade B or C DGE was found in 4 (8.9 %) of 45 patients who underwent CS anastomosis and in 8 (16 %) of 50 patients who underwent HS anastomosis (P?=?0.015). There were no differences in the overall incidence of DGE (P?=?0.98), passage of the contrast medium through the anastomosis (P?=?0.55), or hospital stays (P?=?0.22).Conclusions
CS duodenojejunostomy is not inferior to HS anastomosis with respect to the incidence of clinically significant DGE, justifying its use as treatment option.60.
Kuniyasu NIIZUMA Hiroaki SHIMIZU Takashi INOUE Mika WATANABE Teiji TOMINAGA 《Neurologia medico-chirurgica》2014,54(10):812-818
Carotid endarterectomy (CEA) is intended to remove atheromatous plaque by dissecting a plane between the intima and the media (circular medial fibers), but this may not be the optimal dissection plane. The present technique is based on identifying the plane that divides the media from the plaque, so preserving the media on the adventitia as much as possible. This plane is more difficult to find and follow than the easy-to-dissect plane usually located between the media and the adventitia, because the plaque invades the media and so the dividing plane is located within the media. In this prospective observational study, CEA was performed in 22 patients to histologically examine the excised plaques and small samples of the whole arterial wall, and evaluate the clinical outcomes. Plaque had invaded the luminal part of the media in the whole arterial wall sample of 80% of cases. Thin medial layers covering > 80% of the surface of the plaque were found in 16 of 22 plaques (73%). Some atheromatous component was sometimes left in the preserved media, rather than completely removed with the media. No morbidity or mortality had occurred by discharge. Only 1 small ipsilateral infarction (4.5%) and no restenosis of greater than 50% were detected during the mean follow-up period of 7 years. Since the plaque usually invades the media, the optimum dissection plane may be located within the media, dividing it into two layers. The presence of some remnant atheromatous components in the preserved media was not associated with surgical complications or restenosis. 相似文献