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991.
Akira Tanaka Michio Sato Toshie Tsuchiya Tohru Adachi Toshio Niimura Tsutomu Yamaha 《Archives of toxicology》1986,59(2):82-88
1,2,4-Trichlorobenzene (TCB) labeled with C-14 was given perorally to rats at a dosage of 50 mg/kg for excretion and distribution studies.About 66% and 17% of the oral dose was excreted in the urine and feces, respectively, within 7 days. Trapped radioactivity in the expired air amounted to 2.1% of the dose, but production of labeled carbon dioxide was negligible. Tissue residues were evenly distributed throughout the organs and tissues examined, except for the adipose tissue which consistently had a little higher concentration.The urinary, fecal and expiratory metabolites were identified. Free 2,4,5- and 2,3,5-trichlorophenol (TCP) and their conjugates were mainly detected in the urine. 5- or 6-Sulfhydryl, methylthio, methylsulfoxide and methylsulfone derivatives of TCB were also detected as minor metabolites. Dichlorobenzenes and unchanged TCB were confirmed in the expired air. Reductive dechlroination seems to be catalysed by intestinal microflora enzymes. 相似文献
992.
A 64-year-old man was admitted to our hospital because of headache and fever. Four months before admission, he had suffered from thrombophlebitis of the legs, erythema, oral aphtha and genital ulcers, and was diagnosed as having Beh?et disease. Several days prior to admission he developed fever and was treated with enoxacine, which caused disorientation and abnormal behavior. These psychiatric symptoms disappeared after enoxacine was discontinued. On admission he was neurologically normal. Fever and headache disappeared spontaneously. However, he complained again of headache, and was suspected to have cerebral sinus thrombosis. Brain CT scan showed no abnormality, but brain MRI and cerebral angiography demonstrated right transverse sinus thrombosis and stasis. He was treated with colchicine, isosorbide, and ticlopidine. Because he had a gastric ulcer, corticosteroids were not indicated. Two months later, brain MRI demonstrated reduction of the size of the sinus thrombosis, and the clinical outcome was favorable. We would like to emphasize the usefulness of MRI and colchicine in the patient with Beh?et disease complicated by sinus thromboses. 相似文献
993.
M Fukuda Y Satomi Y Senga H Suzaki M Nakahashi K Ide I Kondo 《Hinyokika kiyo. Acta urologica Japonica》1987,33(7):993-997
Nine cases of metastatic renal cell carcinoma to the lung were studied to assess the efficacy of surgical management. Between January, 1965 and December 1981, 116 cases of metastatic renal cell carcinoma to the lung were treated. Nine of these cases (7.8%), were treated with surgical resection for the pulmonary metastases. The overall crude survival rate after pulmonary resection was 33.3% (3/9) at 3 years and 22.2% (2/9) at 5 years. Two patients are long-term survivors, one still being in good health 108 months, and the other 72 months after pulmonary resection. Pulmonary resection for metastatic renal cell carcinoma was considered effective in some selected slow-growing cases as protection against metastasis from a metastasis. 相似文献
994.
Toshitaka Nagao Isamu Sugano Yasuo Ishida Akira Asoh Shigeru Munakata Kazuto Yamazaki Akiyoshi Konno Keiichi Iwaya Tohru Shimizu Hiromi Serizawa Yoshiro Ebihara 《Modern pathology》2002,15(7):724-733
Hybrid carcinomas of the salivary gland are a recently defined and rare tumor entity, consisting of two histologically distinct types of carcinoma within the same topographic area. In this study, we examined nine such cases, which mainly arose in the parotid gland (seven cases), with an additional one each from submandibular and lacrimal glands, and analyzed their clinicopathologic profiles, including immunohistochemical features and p53 gene alterations. The prevalence of hybrid carcinomas was 0.4% among the 1863 cases of parotid gland tumors in our series. The nine patients comprised five men and four women, ranging in age from 40 to 81 years (mean, 62 y). Tumor size ranged from 2 to 10 cm (mean, 4.2 cm). Of the seven patients who were followed up, two were alive with disease and five were alive with no evidence of disease, although the follow-up period was short. Three cases had cervical lymph nodal metastases. The combinations of carcinoma components in our hybrid carcinomas were as follows: epithelial-myoepithelial carcinoma and basal cell adenocarcinoma in two cases, epithelial-myoepithelial carcinoma and squamous cell carcinoma in one case, salivary duct carcinoma and adenoid cystic carcinoma in two cases, myoepithelial carcinoma and salivary duct carcinoma in one, acinic cell carcinoma and salivary duct carcinoma in one, and squamous cell carcinoma and salivary duct carcinoma in two. Although the proportion of each carcinoma component in a tumor mass varied from case to case, the minor component always represented >or= 10% of the area. Differences in cellular composition were studied by immunohistochemistry and electron microscopy. The Ki-67-labeling index apparently differed between the two carcinoma elements in five cases. Diffusely positive p53 immunoreactivity was observed in four cases, restricted to the more aggressive component in each pair. Furthermore, p53 gene alteration analysis of these p53-positive cases revealed that all and three cases demonstrated loss of heterozygosity at p53 microsatellite loci and p53 gene point mutations, respectively, which were detected only in the p53-immunoreactive carcinoma component. Therefore, there is the possibility that such molecular-genetic events take an integral part for inducing the transformation from histologically lower to higher grade tumor during the hybrid carcinoma genesis of the salivary glands. 相似文献
995.
996.
Hiromune Shimamura Tohru Furukawa Tomohiro Kodama Gaku Matsumoto Mitsuhiro Kimura Tohru Yusa Katsumi Amikura Makoto Sunamura Kazunori Takeda Masao Kobari Seiki Matsuno 《Journal of Hepato-Biliary-Pancreatic Surgery》1997,4(2):168-172
To evaluate appropriate surgical treatment and to predict prognosis for mucin-producing tumors (MPTs) of the pancreas, we
conducted a retrospective clinicopathological study in 25 patients with MPT. Eight patients who had mild dysplasia of the
pancreas were diagnosed with benign disease and 17 patients with ductal lesions of the pancreas with severe dysplasia/carcinoma
in situ or with invasive foci were diagnosed as malignant. Clinical symptoms and histories, tumor markers, cytological examination,
and radiological and gross pathological features were compared in the benign and malignant groups. Clinical symptoms, history,
and tumor markers were of no value for predicting prognosis. Cytological examination results were ambiguous because of too
many falsenegatives. Radiological features, including the diameters of the cystic space and of the main pancreatic duct (MPD)
were shown to be valuable. The significant maximal diameters, above which malignancy was seen, were 30mm for the diameter
of the cystic space and 10mm for the MPD. In regard to gross features, the uniformly dilated main duct-type and focally dilated
main duct-type were significant indicators of malignancy. Long term follow-up was available in 22 patients. Seven patients
died of recurrence of the tumor or other malignancies. We could have predicted prognosis by the radiological features and
gross appearance. Surgical treatment should be considered the primary choice for MPT. Total pancreatectomy would be ideal
for patients with the uniformly dilated main duct-type. Because of the probability of multicentricity and the transforming
potential of mild dysplasia, very careful follow-up is necessary for patients with MPT. 相似文献
997.
Jun Nishigami Tatsunori Takayasu Tohru Ohshima 《International journal of legal medicine》1995,107(4):165-170
Toxicological analysis for chlorpromazine and diazepam was performed using chemically fixed organ tissue specimens. After chlorpromazine and diazepam had been injected into rabbits, organ tissues (brain, lung, liver, kidney and skeletal muscle) were collected and fixed in 3 fixative solutions: buffered 10% formalin solution (pH 7.4, 10% BF), non-buffered 10% formalin solution (pH 5.1, 10% non-BF), buffered 4% paraformaldehyde solution (pH 7.4, 4% BPA). Chlorpromazine and diazepam were determined by GC-MS (gas chromatography-mass spectrometry) after 5 different fixation periods, and were detected even after 28 days of fixation. Recoveries of chlorpromazine and diazepam in 10% BF were within the range 48–86% and 68–171%, respectively after 28-day fixation, those in 10% non-BF were 22–54% and 48–78%, respectively, and those in 4% BPA solution were 13–59% and 14–50%, respectively. Thus, 10% BF was found to be the most suitable fixation medium for analysis of chlorpromazine and diazepam. 相似文献
998.
Nine female technicians using both manual and automatic processingmethods were matched by age, sex and smoking habits with controlsfrom the occupational therapy department. All were interviewedusing a questionnaire about symptoms experienced during theday in question and the preceding month. Sickness absence informationfor 1987 was obtained, and the working environment was assessedby standard occupational hygiene methods. The technicians andcontrols had similar numbers of episodes of sickness absence(23 versus 24, respectively) but aggregated substantially moredays absence attributed to sickness (204 versus 41). The totalnumber of monthly symptoms experienced by thetechnicians was greater than the controls (44 versus 30) aswas the number of daily complaints (26 versus6). In all cases, respiratory symptoms were responsible forabout one-third of problems, but statistical analysis (Wilcoxonmatched pairs signed ranks tests) showed that the differenceswere not statistically significant. Occupational hygiene resultswere all within normal limits. 相似文献
999.
Fusao Ikawa Tohru Uozumi Katsuzo Kiya Kazunori Arita Kaoru Kurisu Kunyu Harada 《Neurosurgical review》1995,18(4):277-280
Orbital apex syndrome is a symptomatologic complex. In this paper, the usefulness of several clinical diagnostic MR methods in preparing for surgery is discussed. These include dynamic MRI and the spoiled GRASS (SPGR) image for a cavernous sinus meningioma presenting with orbital apex syndrome. A 53 year old man, who had right cavernous sinus tumor presenting with orbital apex syndrome, was examined by several new MRI techniques. The tumor was partially removed and fibroblastic meningioma was confirmed pathologically. 相似文献
1000.