全文获取类型
收费全文 | 17353篇 |
免费 | 1211篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 166篇 |
儿科学 | 547篇 |
妇产科学 | 453篇 |
基础医学 | 2238篇 |
口腔科学 | 123篇 |
临床医学 | 2409篇 |
内科学 | 3194篇 |
皮肤病学 | 238篇 |
神经病学 | 1607篇 |
特种医学 | 430篇 |
外科学 | 1915篇 |
综合类 | 179篇 |
一般理论 | 16篇 |
预防医学 | 2162篇 |
眼科学 | 245篇 |
药学 | 1152篇 |
中国医学 | 15篇 |
肿瘤学 | 1503篇 |
出版年
2023年 | 103篇 |
2022年 | 71篇 |
2021年 | 387篇 |
2020年 | 249篇 |
2019年 | 418篇 |
2018年 | 476篇 |
2017年 | 351篇 |
2016年 | 395篇 |
2015年 | 470篇 |
2014年 | 603篇 |
2013年 | 895篇 |
2012年 | 1354篇 |
2011年 | 1358篇 |
2010年 | 724篇 |
2009年 | 691篇 |
2008年 | 1076篇 |
2007年 | 1225篇 |
2006年 | 1184篇 |
2005年 | 1166篇 |
2004年 | 1008篇 |
2003年 | 997篇 |
2002年 | 847篇 |
2001年 | 167篇 |
2000年 | 162篇 |
1999年 | 202篇 |
1998年 | 194篇 |
1997年 | 131篇 |
1996年 | 120篇 |
1995年 | 120篇 |
1994年 | 98篇 |
1993年 | 91篇 |
1992年 | 86篇 |
1991年 | 81篇 |
1990年 | 84篇 |
1989年 | 59篇 |
1988年 | 86篇 |
1987年 | 69篇 |
1986年 | 66篇 |
1985年 | 48篇 |
1984年 | 65篇 |
1983年 | 45篇 |
1982年 | 61篇 |
1981年 | 43篇 |
1980年 | 46篇 |
1979年 | 33篇 |
1978年 | 36篇 |
1977年 | 27篇 |
1976年 | 29篇 |
1975年 | 30篇 |
1973年 | 27篇 |
排序方式: 共有10000条查询结果,搜索用时 435 毫秒
21.
Association of Hypoalbuminemia on the First Postoperative Day and Complications Following Esophagectomy 总被引:1,自引:0,他引:1
Aoife M. Ryan Aine Hearty Ruth S. Prichard Aileen Cunningham Suzanne P. Rowley John V. Reynolds 《Journal of gastrointestinal surgery》2007,11(10):1355-1360
Objective Changes in serum albumin may reflect systemic immunoinflammation and hypermetabolism in response to insults such as trauma
and sepsis. Esophagectomy is associated with a major metabolic stress, and the aim of this study was to determine if the absolute
albumin level on the first postoperative day was of value in predicting in-hospital complications.
Methods A retrospective study of 200 patients undergoing esophagectomy for malignant disease at St. James Hospital between 1999 and
2005 was performed. Patients who had pre and postoperative (days 1, 3, and 7) serum albumin levels measured were included
in the study. Patients were subdivided into three postoperative albumin categories <20 g/l, 20–25 g/l, >25 g/l. Logistic regression
analysis was performed to calculate the odds of morbidity and mortality according to the day 1 albumin level.
Results Patients with an albumin of less than 20 g/l on the first postoperative day were twice as likely to develop postoperative
complications than those with an albumin of greater than 20 g/l (54 vs 28% respectively, p < 0.011). Correspondingly, these patients also had a significantly higher rate of Adult Respiratory Distress Syndrome (22
vs 5%, p < 0.001), respiratory failure (27 vs 8%, p < 0.01) and in-hospital mortality (27 vs 6% (p < 0.001). On multivariate logistic regression analysis, day 1 albumin level was independently related to postoperative complications
(odds ratios, 0.89: 95%; confidence intervals, 0.83–0.96; p < 0.005). In addition, albumin <20 g/l on the first postoperative day was associated with the need for further surgery and
a return to ICU.
Conclusion Serum albumin concentration on the first postoperative day is a better predictor of surgical outcome than many other preoperative
risk factors. It is a low cost test that may be used as a prognostic tool to detect the risk of adverse surgical outcomes. 相似文献
22.
Ohne Zusammenfassung 相似文献
23.
Franz F Immer Urs Hagen Pascal A Berdat Friedrich S Eckstein Thierry P Carrel 《European journal of cardio-thoracic surgery》2005,27(4):654-657
OBJECTIVES: Prompt diagnosis of subsequent dilatation of the dissected aorta is crucial to reduce late mortality in these patients. This study focuses on risk factors for dilatation of the aorta after type A aortic dissection (AADA) affecting a normal-sized or slightly dilated aorta. METHODS: Overall 531 CT scans were analysed. Patients were included in the study if at least 3 CT scans were available after operative repair. 64 patients (59.8%) out of 107 patients full-field the inclusion criteria. Volumetric analyses of the aorta were performed. Patients were divided in 3 groups: group A included 26 patients (40.6%) without progression of the aortic diameter, group 2, 27 patients (42.2%) with slight progression and group 3, 11 patients (17.2%) with important progression, requiring surgery in 9 patients (81.8%). Risk-factors for progression of the aortic size were analysed and compared between the groups. RESULTS: Patients from group 3 were younger 57.7+/-13.4 vs. 61.9+/-11.6 in group 1 (P<0.05) and were more frequent female (45.4 vs. 23.1%; P<0.05). Dissection of the supraaortic branches (100 vs. 80.8%; P<0.05), the presence of preoperative cerebral, visceral or peripheral malperfusion (54.6 vs. 26.9%; P<0.05) and contrast enhancement in the false lumen during the follow-up (72.7 vs. 57.7%; P=0.07) were additional risk factors for late aortic dilatation in these patients. CONCLUSIONS: Acute type A aortic dissection in younger patients, involving the supraaortic branches and/or combined with malperfusion syndrome favour secondary dilatation. A close follow-up is mandatory to prevent acute complications of the diseased downstream aorta following repair of a AADA. 相似文献
24.
Association of polymorphonuclear leukocytes with sites of aortic catheter-induced injury in rabbits 总被引:4,自引:0,他引:4
C W Cole P O Hagen J F Lucas E M Mikat M K O'Malley Z S Radic R G Makhoul R L McCann 《Atherosclerosis》1987,67(2-3):229-236
The kinetics of the association of polymorphonuclear leukocytes (PMNs) with arterial balloon catheter-induced injury have been examined. An average of 6 X 10(7) PMNs were isolated from 20 ml of blood and labelled with 111In-oxine for reinfusion into the donor rabbit. The cells remained viable as demonstrated by both in vitro and in vivo tests of cell function. The abdominal aorta of rabbits was denuded of endothelium and immediately, 24 h, or 5 weeks later, exposed to autologous radiolabelled PMNs for 1 h. The presence of PMNs at sites of denudation was demonstrated by detection of the radioactive label and was confirmed by light and electron microscopy after 24 h, but not at 5 weeks. Immediately following denudation radioactivity was 2.44 +/- 0.33 times control (P = 0.006); 2.52 +/- 0.18 at 24 h (P = 0.005); and 1.88 +/- 0.32 times control at 5 weeks (P = 0.045). The presence of PMNs, or their products, 5 weeks after denudation suggests a more complex role of PMNs and possibly a direct involvement in the long term changes resulting from arterial balloon catheter injury. 相似文献
25.
Dysphagia was studied in 29 patients after implantation of an Angelchik prosthesis for persistent reflux oesophagitis. The incidence of postoperative dysphagia occurred after three months (61%), six months (45%), and one year or more (41%). Severe dysphagia necessitated removal of the prosthesis in five patients (17%). The reoperative findings with regard to a possible explanation of dysphagia are discussed, and comparison is made with reports in literature. Implantation of the Angelchik prosthesis seems only indicated for the treatment of intractable reflux oesophagitis in patients where other operative modalities failed and who are at high risk for operation. The Nissen fundoplication remains the operation of choice. 相似文献
26.
Dr. James C. Garrelts Pharm.D. W. Dale Horst Ph.D. Beryl Silkey Sc.M. Dr. Suzanne Gagnon M.D. 《Pharmacotherapy》1994,14(4):438-445
Study Objectives . To characterize patient sociodemographics and health, describe vancomycin treatment parameters and clinician-rated outcomes, and determine costs associated with treatment including preparation and administration, adverse events, and toxicity. Design . A prospective study to develop a model for costs associated with antibiotic treatment (vancomycin). Setting . A community hospital. Patients . One hundred adults with active infections. Interventions . Mean duration of therapy was 10 days, and most patients received 2000 mg/day. Serum concentrations were monitored in two of three patients. Detailed cost analyses were completed on a subset of 26 patients selected at random from the overall sample. Measurements and Main Results . Sepsis and skin and skin structure infections were the most common indications for vancomycin therapy. Treatment was effective in 81 patients, failed in 9, and was not evaluable in 10. Thirty-eight percent of patients experienced adverse events attributable to the drug. Phlebitis was common, and red man syndrome, nephrotoxicity, and ototoxicity were infrequent. Conclusions . Total cost of vancomycin treatment for 100 patients was $30,251: $23,855 for preparation and administration, $1710 for monitoring serum concentrations, and $4686 for treating adverse reactions. Drug costs accounted for only 55% of the total cost. Vancomycin is safe and effective, but phlebitis is underreported and significantly affects cost. 相似文献
27.
The synthesis of the title compounds starting from 2-Chlormethylbenzdioxan and Tetrahydroisochinolines is presented. Their actions on the platelet aggregation and the inhibition of alpha-adrenoceptors at the isolated rabbit aorta and the vas deferens of the guinea pig were investigated. 相似文献
28.
29.
Ohne Zusammenfassung 相似文献
30.