全文获取类型
收费全文 | 1995篇 |
免费 | 66篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 37篇 |
妇产科学 | 33篇 |
基础医学 | 150篇 |
口腔科学 | 29篇 |
临床医学 | 106篇 |
内科学 | 541篇 |
皮肤病学 | 16篇 |
神经病学 | 102篇 |
特种医学 | 51篇 |
外科学 | 514篇 |
综合类 | 7篇 |
预防医学 | 70篇 |
眼科学 | 8篇 |
药学 | 111篇 |
中国医学 | 5篇 |
肿瘤学 | 273篇 |
出版年
2023年 | 8篇 |
2022年 | 9篇 |
2021年 | 42篇 |
2020年 | 25篇 |
2019年 | 30篇 |
2018年 | 33篇 |
2017年 | 30篇 |
2016年 | 44篇 |
2015年 | 48篇 |
2014年 | 48篇 |
2013年 | 77篇 |
2012年 | 106篇 |
2011年 | 126篇 |
2010年 | 63篇 |
2009年 | 66篇 |
2008年 | 122篇 |
2007年 | 141篇 |
2006年 | 119篇 |
2005年 | 134篇 |
2004年 | 115篇 |
2003年 | 119篇 |
2002年 | 125篇 |
2001年 | 32篇 |
2000年 | 32篇 |
1999年 | 36篇 |
1998年 | 30篇 |
1997年 | 20篇 |
1996年 | 22篇 |
1995年 | 13篇 |
1994年 | 7篇 |
1992年 | 14篇 |
1991年 | 22篇 |
1990年 | 24篇 |
1989年 | 13篇 |
1988年 | 20篇 |
1987年 | 15篇 |
1986年 | 18篇 |
1985年 | 17篇 |
1984年 | 12篇 |
1983年 | 21篇 |
1981年 | 7篇 |
1980年 | 10篇 |
1979年 | 5篇 |
1978年 | 4篇 |
1977年 | 7篇 |
1974年 | 4篇 |
1969年 | 4篇 |
1968年 | 5篇 |
1967年 | 4篇 |
1966年 | 5篇 |
排序方式: 共有2078条查询结果,搜索用时 31 毫秒
61.
T Tsuzuki H Iwase M Shimada N Hirashima Y Hibino N Ryuge M Saito D Tamaki A Kamiya M Yokoi Y Yokomaku S Fujisaki W Sugiura H Goto 《Nihon Shokakibyo Gakkai zasshi》2012,109(7):1186-1196
At Nagoya Medical Center, 10 patients co-infected with HIV and HCV received peginterferon α (PEG-IFNα) plus ribavirin therapy. Three of the cases were HCV genotype 1b, 2 cases were HCV 3b, and 1 case each were 2b, 2c, 3a, 4a and 6n. Nine patients received anti HIV therapy from the beginning. In 5 of these patients, anti HIV therapy was modified when PEG-IFNα plus ribavirin treatment was started. Of the above, 7 patients completed the protocol. No patients had severe adverse effects. Sustained virological response was achieved in 1 of 4 (25%) of the patients with genotypes 1 or 4, and in 5 of 6 (83%) of the patients with other genotypes. PEG-IFNα plus ribavirin therapy is considered a safe and efficacious treatment for patients co-infected with HIV and HCV. 相似文献
62.
63.
Chie Shimizu Takayuki Fujita Yoshinobu Fuke Minako Yabuki Mamiko Kajiwara Seiichiro Hemmi Atsushi Satomura Masayoshi Soma 《International urology and nephrology》2013,45(3):803-808
Purpose
Cyclosporine (CsA) is often prescribed to patients with glucocorticoid (GC)-dependent nephrotic syndrome. Although it is well known that long-term administration of GC causes osteoporosis, the effects of CsA on bone metabolism are not fully established. Therefore, we examined the effects of CsA on bone metabolism in patients with GC-dependent nephrotic syndrome in remission.Methods
We followed 23 patients treated with prednisolone alone (GC alone group) and 17 patients treated with CsA in combination with prednisolone (GC + CsA group). Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry, and biochemical markers of bone metabolism were simultaneously measured in serum and urine samples.Results
BMD decreased significantly in the GC group from 752 to 623 mg/cm2 but non-significantly in the GC + CsA group from 751 to 684 mg/cm2. Although the cumulative dose of GC increased in both groups, there were no significant differences in biochemical markers at either the start or the end of the study. Vertebrate bone fracture and other side effects associated with CsA treatment did not occur in our study.Conclusions
Our results indicate that CsA does not accelerate GC-induced osteoporosis in patients with nephrotic syndrome. We conclude that CsA is appropriate for the treatment of GC-dependent nephrotic syndrome, because it does not adversely affect bone metabolism and has favorable glomerular effects. 相似文献64.
65.
Shigehiro Uezono Seiichiro Hara Yuji Sato Hiroyuki Komatsu Naoko Ikeda Yoshiya Shimao 《Renal failure》2013,35(7):549-555
As the numbers of aging patients with manifestations of renal disease increase, the elderly must frequently undergo renal biopsies. This study examined the characteristics of clinicopathological correlations in elderly patients. Medical and clinical records from renal biopsies registered in two hospitals between January 2000 and December 2004 were reviewed. Among 406 patients (female: male 224/182; age 43.9 ± 18.8 years, mean ± SD) who underwent renal biopsies, 61 (15.1%) who were aged 65 years and older (female: male, 29/32; age 72.8 ± 5.2 years) were selected. The elderly usually underwent percutaneous renal biopsies for renal diseases such as nephrotic syndrome (43%) and acute or rapidly progressive renal failure (A/RPRF, 39%). Focal/segmental glomerulosclerosis (23%), minimal change disease (19%), and membranous nephropathy (15%) are frequently diagnosed based on biopsy specimens from patients with nephrotic syndrome. Among patients presenting with A/RPRF, 17 (71%) and 4 (17%) had pauci-immune, MPO-ANCA positive, crescentic glomerulonephritis and interstitial nephritis, respectively, and benefited from therapeutic intervention. Histopathological and pre-biopsy clinical diagnoses differed in nine (15%) patients. The complication rate after biopsy was low (3%). Primary glomerular diseases presenting with nephrotic syndrome and primary crescentic glomerulonephritis associated with rapidly progressive renal failure were the most frequently diagnosed among the elderly who underwent renal biopsy. Percutaneous renal biopsy provides clinically useful information about the elderly because clinical presentation and the predicted diagnosis sometimes vary. 相似文献
66.
Tetsuyoshi Horiuchi Junpei Nitta Shigetoshi Ishizaka Kohei Kanaya Takao Yanagawa Kazuhiro Hongo 《Neurosurgical review》2013,36(4):559-565
Previous studies have shown that extracranial–intracranial (EC-IC) bypass surgery has no preventive effect on subsequent ipsilateral ischemic stroke in patients with symptomatic atherosclerotic internal carotid occlusion and hemodynamic cerebral ischemia. A few studies have assessed whether an urgent EC-IC bypass surgery is an effective treatment for main trunk stenosis or occlusion in acute stage. The authors retrospectively reviewed 58 consecutive patients who underwent urgent EC-IC bypass for symptomatic internal carotid artery or the middle cerebral artery stenosis or occlusion between January 2003 and December 2011. Clinical characteristics and neuroimagings were evaluated and analyzed. Based on preoperative angiogram, responsible lesions were the internal carotid artery in 19 (32.8 %) patients and the middle cerebral artery in 39 (67.2 %). No hemorrhagic complication occurred. Sixty-nine percent of patients showed improvement of neurological function after surgery, and 74.1 % of patients had favorable outcome. Unfavorable outcome was associated with insufficient collateral flow and new infarction after bypass surgery. 相似文献
67.
Background
Low fraction of inspired oxygen (FIO2) reduces the atelectasis area during anesthesia induction. However, atelectasis may occur during laryngoscopy and endotracheal intubation because lungs can collapse within a fraction of a second. We assessed the effects of ventilation with 100 and 40 % oxygen on functional residual capacity (FRC) in patients undergoing general anesthesia.Methods
Twenty patients scheduled for elective open abdominal surgery were randomized into 40 % oxygen (GI, n = 10) and 100 % oxygen (GII, n = 10) groups and FRC was measured. Preoxygenation and mask ventilation with 40 and 100 % oxygen were used in GI and GII, respectively. In both groups, 40 % oxygen was used for anesthesia maintenance after intubation. Bilateral lung ventilation was performed with volume guarantee and low tidal volume (7 ml/kg predicted body weight) using bilevel airway pressure. We measured FRC and blood gas in all patients during preoxygenation, after intubation, and during surgery.Results
FRC decreased from during preoxygenation (GI 2380 ml, GII 2313 ml) to after intubation (GI 1569 ml, GII 1586 ml) and significantly decreased during surgery (GI 1338 ml, GII 1417 ml) (P < 0.05). PaO2/FIO2 decreased from during preoxygenation (GI 419 mmHg, GII 427 mmHg) to after intubation (GI 381 mmHg, GII 351 mmHg) and significantly decreased during surgery (GI 333 mmHg, GII 291 mmHg) (P < 0.05). No significant differences were found between the groups in both parameters.Conclusions
FRC significantly decreased from the awake state to surgery in both groups. FRC was not influenced by FIO2 elevation at anesthesia induction. 相似文献68.
Kentaro Chiba Yasuo Aihara Seiichiro Eguchi Masahiko Tanaka Takashi Komori Yoichi Nakazato Yoshikazu Okada 《Child's nervous system》2013,29(6):1039-1045
Introduction
Juvenile xanthogranuloma (JXG) preferentially occurs in childhood, and its characteristics have been thought to be benign and with slow growth. JXG is classified as an inflammatory disease, which forms multiple lesions in the patients’ head, neck, and other organs and typically skin. JXG is rare, and few case reports have been published in the past, particularly with multiple intracranial lesions, which as in our case, is an extremely rare finding.Case
Patient is a 4-year-old boy who presented with polydypsia and polyuria for 1 year. He had been followed up only under l-deamino-8-d-arginine vasopressin until he started vomiting and his level of consciousness deteriorated. Then, magnetic resonance imaging (MRI) revealed multiple intracranial lesions. He underwent biopsy via small craniotomy, and pathology was confirmed as juvenile xanthogranuloma. The patient received chemotherapy, in complete compliance with JLSG-02 protocol.Findings
JXG is characteristic with homogenous enhancement with contrast matter and, most importantly, high intensity on diffusion-weighted image (DWI). The DWI was high when the degree of diffusion of water is restricted, as seen in inflammation and, additionally, the change of intensity after administration of steroid would reflect its anti-inflammatory nature. However, though the steroid therapy made high-intensity lesions decrease signal intensity, the size and the number of lesions did not change at all. As we expected, after we stopped steroid administration to the patient, his consciousness deteriorated and we found again the very-high-intensity lesions. We consider the intensity on DWI to reflect progression of the lesions. 相似文献69.
Comparison of mirabegron and imidafenacin for efficacy and safety in Japanese female patients with overactive bladder: A randomized controlled trial (COMFORT study) 下载免费PDF全文
70.