全文获取类型
收费全文 | 2025篇 |
免费 | 110篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 98篇 |
妇产科学 | 34篇 |
基础医学 | 232篇 |
口腔科学 | 77篇 |
临床医学 | 126篇 |
内科学 | 282篇 |
皮肤病学 | 17篇 |
神经病学 | 238篇 |
特种医学 | 25篇 |
外科学 | 255篇 |
综合类 | 34篇 |
预防医学 | 89篇 |
眼科学 | 152篇 |
药学 | 263篇 |
中国医学 | 10篇 |
肿瘤学 | 199篇 |
出版年
2023年 | 15篇 |
2022年 | 23篇 |
2021年 | 109篇 |
2020年 | 52篇 |
2019年 | 60篇 |
2018年 | 95篇 |
2017年 | 36篇 |
2016年 | 72篇 |
2015年 | 78篇 |
2014年 | 100篇 |
2013年 | 120篇 |
2012年 | 231篇 |
2011年 | 214篇 |
2010年 | 118篇 |
2009年 | 90篇 |
2008年 | 132篇 |
2007年 | 111篇 |
2006年 | 113篇 |
2005年 | 81篇 |
2004年 | 86篇 |
2003年 | 51篇 |
2002年 | 39篇 |
2001年 | 16篇 |
2000年 | 17篇 |
1999年 | 6篇 |
1998年 | 11篇 |
1997年 | 5篇 |
1996年 | 7篇 |
1995年 | 10篇 |
1994年 | 8篇 |
1993年 | 4篇 |
1992年 | 1篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1989年 | 4篇 |
1988年 | 1篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1984年 | 1篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1980年 | 4篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1970年 | 1篇 |
1968年 | 1篇 |
1964年 | 1篇 |
1956年 | 1篇 |
排序方式: 共有2145条查询结果,搜索用时 26 毫秒
21.
AIM: To study the in vivo anti-inflammatory activity of Tabernaemontana divaricata leaf extract on male albino mice. METHODS: Aqueous decoction and methanol leaf extracts were tested for their ability to reduce croton oil-induced edema in the mouse ear after topical application. The methanol leaf extract dose-dependently inhibited the croton oil-induced ear edema in mice (ID50 〈500 μg.cm-2). A bioassay-guided liquid-liquid fractionation of this methanol extract gave four active fractions: water insoluble (F1), hexane (F2), ethyl acetate (F3) and water (F4). RESULTS: The hexane fraction showed a very high activity (42.1% inhibition at 0.7 μg.cm-2) as compared to the control. The other fractions were less active (FI: 56.1% at 506.2 μg.cm-2; F3: 57.3% at 289.3 lag.cm-2; and F4: 31.9% for 203.8 μg.cm-2) while indomethacin gave 48.8% of inhibition at 90 μg-cm-2. The activity of F1 and F3 may be at least in part explained by the presence of anti-inflammatory flavonoids, while the activity was not correlated to the tannin contents. No compounds were detected in the most active F2 fraction. CONCLUSIONS: The results give a rational support to the traditional use of T. divaricata in tropical India as anti-inflammatory agent. 相似文献
22.
Krishna A Dani Celestine Santosh David Brennan Donald M Hadley Keith W Muir 《Journal of cerebral blood flow and metabolism》2012,32(12):2114-2117
Hyperoxia during T2*-weighted magnetic resonance imaging (oxygen challenge imaging (OCI)) causes T2*-weighted signal change that is dependent on cerebral blood volume (CBV) and oxygen extraction fraction (OEF). Crossed cerebellar diaschisis (CCD), where CBV is reduced but OEF is maintained, may be used to understand the relative contributions of OEF and CBV to OCI results. In subjects with large hemispheric strokes, OCI showed reduced signal change in the contralesional cerebellum (P=0.027, n=12). This was associated with reduced CBV in contralesional cerebellum (P=0.039, n=9). CCD may be a useful model to determine the relative contribution of CBV to signal change measured by OCI. 相似文献
23.
24.
Yash Paul Sharma Krishna Santosh Vemuri Dinakar Bootla Kewal Kanabar C.R. Pruthvi Navjyot Kaur Krishna Prasad Nevali Prashant Panda G. Kasinadhuni Lipi Uppal Soumitra Mohanty 《Indian heart journal》2021,73(2):174-179
BackgroundCardiovascular disease is the leading cause of death in India. Our aim is to study the clinical, epidemiological profile and in-hospital outcomes of patients presenting with acute coronary syndrome.MethodsWe did a prospective single center observational study of the 1203 patients presenting with ACS to a tertiary referral center in North India over a period of one year (July 2018–June 2019).ResultsThe mean age of study population was 58.4 ± 12.5 years. STEMI and NSTE-ACS accounted for 69.9% and 31.1% respectively. 62.1% of our patients were from rural background. The median time to hospital admission was 600 min for STEMI patients, thrombolysis was performed in 52% of cases. Cardiogenic shock at presentation was noted in 18%. Coronary angiography and percutaneous coronary intervention were done in 1062 (88.3%) and 733 (60.9%) patients respectively. The overall in-hospital mortality was 7.6%. STEMI patients had higher mortality than NSTE-ACS (8.9% vs 4.5% p < 0.001). Female gender (OR?3.306 C.I. 1.87–5.845), severe MR (OR?4.65, C.I.?1.187–18.18), acute kidney injury (AKI) at admission (OR-5.15, C.I.?2.5–10.63), higher Killip class (class III/IV) (OR?3.378,C.I.?1.292–8.849), AF (OR?3.25, C.I.?1,18–8.92), complete heart block (CHB) (OR?4.44,C.I.?2.09–9.43) and right bundle branch block (RBBB) (OR?2.86, C.I.?1.2–6.8) were significant predictors of in hospital mortality.ConclusionsOur study represents the predominance of STEMI as the initial ACS presentation with a considerable delay in first medical contact and higher prevalence of cardiogenic shock (CS). STEMI patients had higher mortality. Female sex, severe MR, AKI, higher Killips class, AF, CHB, RBBB being predictors of high in-hospital mortality in ACS patients. 相似文献
25.
Gentle Sunder Shrestha Pankaj Joshi Santosh Chhetri Ragesh Karn Subhash Prasad Acharya 《Indian Journal of Critical Care Medicine》2015,19(5):283-285
Refractory and super-refractory status epilepticus is a life-threatening neurological emergency, associated with high morbidity and mortality. Treatment should be aimed to stop seizure and to avoid cerebral damage and another morbidity. Published data about effectiveness, safety and outcome of various therapies and treatment approaches are sparse and are mainly based on small case series and retrospective data. Here we report successful management of two cases of super-refractory status epilepticus refractory to anesthetic therapy with midazolam and complicated by septic shock, managed successfully with ketamine infusion. 相似文献
26.
Santosh Paiaulla Pradeep Marur Venkategowda S. Manimala Rao Banda Balaraju 《Indian Journal of Critical Care Medicine》2015,19(8):484-486
Hyperthyroidism is a condition characterized by excessive production of thyroid hormones. Propylthiouracil (PTU) is commonly used as first line drug in the management of hyperthyroidism. This is a case report of 24-year-old female, a known case of hyperthyroidism since 4 years, who came with a history of fever and myalgia since 3 days and dyspnea with coughing out of blood since 1 day. Patient was taking PTU (100 mg per day) since 4 years for hyperthyroidism. Patient was immediately intubated for type-II respiratory failure. Diagnosed to be having PTU-induced autoimmune disease. PTU was stopped and treated with methylprednisolone and cyclophosphamide. Clinical features improved over a period of 8 days and discharged home successfully. Having a high suspicion for the onset of autoimmune disease in hyperthyroidism patients who are on PTU therapy and timely treatment with immunosuppressants and supportive care along with the withdrawal of the drug can make a difference in morbidity and mortality. 相似文献
27.
Tumors of the Ocular Surface clinically manifest with a very wide spectrum and include several forms of epithelial, stromal, caruncular, and secondary tumors. As a group, these tumors are seen commonly in the clinical practice of a comprehensive ophthalmologist, cornea specialist, and an ocular oncologist. This review is aimed to discuss the common tumors of the ocular surface and emphasize on their clinical diagnosis and appropriate management. 相似文献
28.
29.
Enes Elvin Gul MD Rajiv A. Kabadi MD Santosh K. Padala MD Paula Sanchez Somonte MD Jordana Kron MD Richard K. Shepard MD Jayanthi N. Koneru MD Gautham Kalahasty MD Maria Terricabras MD Bernice Tsang MD Yaariv Khaykin MD Zaev Wulffhart MD Alfredo Pantano MD Kenneth A. Ellenbogen MD Atul Verma MD 《Journal of cardiovascular electrophysiology》2021,32(9):2515-2521
30.
Janelle C. Waite Santosh Vardhana Patrick J. Shaw Jung‐Eun Jang Christie‐Ann McCarl Thomas O. Cameron Stefan Feske Michael L. Dustin 《European journal of immunology》2013,43(12):3343-3354
Entry of lymphocytes into secondary lymphoid organs (SLOs) involves intravascular arrest and intracellular calcium ion ([Ca2+]i) elevation. TCR activation triggers increased [Ca2+]i and can arrest T‐cell motility in vitro. However, the requirement for [Ca2+]i elevation in arresting T cells in vivo has not been tested. Here, we have manipulated the Ca2+ release‐activated Ca2+ (CRAC) channel pathway required for [Ca2+]i elevation in T cells through genetic deletion of stromal interaction molecule (STIM) 1 or by expression of a dominant‐negative ORAI1 channel subunit (ORAI1‐DN). Interestingly, the absence of CRAC did not interfere with homing of naïve CD4+ T cells to SLOs and only moderately reduced crawling speeds in vivo. T cells expressing ORAI1‐DN lacked TCR activation induced [Ca2+]i elevation, yet arrested motility similar to control T cells in vitro. In contrast, antigen‐specific ORAI1‐DN T cells had a twofold delayed onset of arrest following injection of OVA peptide in vivo. CRAC channel function is not required for homing to SLOs, but enhances spatiotemporal coordination of TCR signaling and motility arrest. 相似文献