全文获取类型
收费全文 | 3755篇 |
免费 | 231篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 126篇 |
妇产科学 | 59篇 |
基础医学 | 497篇 |
口腔科学 | 54篇 |
临床医学 | 307篇 |
内科学 | 903篇 |
皮肤病学 | 83篇 |
神经病学 | 344篇 |
特种医学 | 56篇 |
外科学 | 421篇 |
综合类 | 8篇 |
一般理论 | 3篇 |
预防医学 | 342篇 |
眼科学 | 36篇 |
药学 | 275篇 |
中国医学 | 9篇 |
肿瘤学 | 454篇 |
出版年
2023年 | 23篇 |
2022年 | 26篇 |
2021年 | 147篇 |
2020年 | 61篇 |
2019年 | 130篇 |
2018年 | 151篇 |
2017年 | 95篇 |
2016年 | 90篇 |
2015年 | 98篇 |
2014年 | 145篇 |
2013年 | 194篇 |
2012年 | 309篇 |
2011年 | 303篇 |
2010年 | 176篇 |
2009年 | 162篇 |
2008年 | 231篇 |
2007年 | 174篇 |
2006年 | 178篇 |
2005年 | 180篇 |
2004年 | 150篇 |
2003年 | 119篇 |
2002年 | 144篇 |
2001年 | 68篇 |
2000年 | 77篇 |
1999年 | 54篇 |
1998年 | 34篇 |
1997年 | 27篇 |
1996年 | 19篇 |
1995年 | 12篇 |
1994年 | 20篇 |
1993年 | 18篇 |
1992年 | 41篇 |
1991年 | 24篇 |
1990年 | 31篇 |
1989年 | 27篇 |
1988年 | 26篇 |
1987年 | 22篇 |
1986年 | 21篇 |
1985年 | 16篇 |
1984年 | 11篇 |
1983年 | 8篇 |
1979年 | 18篇 |
1977年 | 8篇 |
1975年 | 7篇 |
1974年 | 10篇 |
1973年 | 9篇 |
1972年 | 8篇 |
1969年 | 12篇 |
1968年 | 8篇 |
1965年 | 9篇 |
排序方式: 共有3992条查询结果,搜索用时 24 毫秒
31.
Gabriele Piuri Monica Zocchi Matteo Della Porta Valentina Ficara Michele Manoni Gian Vincenzo Zuccotti Luciano Pinotti Jeanette A. Maier Roberta Cazzola 《Nutrients》2021,13(2)
Magnesium (Mg2+) deficiency is probably the most underestimated electrolyte imbalance in Western countries. It is frequent in obese patients, subjects with type-2 diabetes and metabolic syndrome, both in adulthood and in childhood. This narrative review aims to offer insights into the pathophysiological mechanisms linking Mg2+ deficiency with obesity and the risk of developing metabolic syndrome and type 2 diabetes. Literature highlights critical issues about the treatment of Mg2+ deficiency, such as the lack of a clear definition of Mg2+ nutritional status, the use of different Mg2+ salts and dosage and the different duration of the Mg2+ supplementation. Despite the lack of agreement, an appropriate dietary pattern, including the right intake of Mg2+, improves metabolic syndrome by reducing blood pressure, hyperglycemia, and hypertriglyceridemia. This occurs through the modulation of gene expression and proteomic profile as well as through a positive influence on the composition of the intestinal microbiota and the metabolism of vitamins B1 and D. 相似文献
32.
Judit Companys Maria Jos Gosalbes Laura Pla-Pag Lorena Caldern-Prez Elisabet Llaurad Anna Pedret Rosa Maria Valls Nuria Jimnez-Hernndez Berner Andre Sandoval-Ramirez Josep Maria del Bas Antoni Caimari Laura Rubi Rosa Sol 《Nutrients》2021,13(6)
We aimed to differentiate gut microbiota composition of overweight/obese and lean subjects and to determine its association with clinical variables and dietary intake. A cross-sectional study was performed with 96 overweight/obese subjects and 32 lean subjects. Anthropometric parameters were positively associated with Collinsella aerofaciens, Dorea formicigenerans and Dorea longicatena, which had higher abundance the overweight/obese subjects. Moreover, different genera of Lachnospiraceae were negatively associated with body fat, LDL and total cholesterol. Saturated fatty acids (SFAs) were negatively associated with the genus Intestinimonas, a biomarker of the overweight/obese group, whereas SFAs were positively associated with Roseburia, a biomarker for the lean group. In conclusion, Dorea formicigenerans, Dorea longicatena and Collinsella aerofaciens could be considered obesity biomarkers, Lachnospiraceae is associated with lipid cardiovascular risk factors. SFAs exhibited opposite association profiles with butyrate-producing bacteria depending on the BMI. Thus, the relationship between diet and microbiota opens new tools for the management of obesity. 相似文献
33.
M. Teresa Gómez Hernández Marta Fuentes Gago Nuria Novoa Valentín Israel Rodríguez Alvarado Marcelo F. Jiménez López 《Cirugía espa?ola》2021,99(6):421-427
IntroductionRobotic surgery has become a safe and effective approach for the treatment of pulmonary surgical pathology. However, the adoption of new surgical techniques requires the evaluation of the learning curve. The objective of this study is to analyze the learning curve of robotic anatomical lung resections.MethodsRetrospective analysis of all robotic anatomical lung resections performed by the same surgeon between June 2018 and March 2020. The learning curve was evaluated using CUSUM charts to estimate trend changes in surgical time, surgical failure and the occurrence of post-operative cardiorespiratory complications throughout the sequence of cases.ResultsThe study included a total of 73 cases. The median duration of all complications was 120 min (interquartile range: 90-150 min), the prevalence of surgical failure was 23.29%, while 4/73 patients had any postoperative cardiorespiratory complication. Based on the CUSUM analysis, the learning curve was divided into 3 different phases: phase i (from the first to the 14th intervention), phase ii (between the 15th and 30th intervention) and phase iii (from the 31st intervention).ConclusionsThe learning curve for robotic anatomical lung resections can be divided into 3 phases. The technical competence that guarantees satisfactory perioperative outcomes was achived in phase iii from the 31st intervention. 相似文献
34.
Daniel López-Padilla Francisco García-Río Adolfo Alonso-Arroyo Nuria Arenas Valls Alicia Cerezo Lajas Marta Corral Blanco Virginia Gallo González Milagros Llanos Flores María Martínez Redondo Natalia Martos Gisbert Elena Ojeda Castillejo Marta Padilla Bernáldez Marta Pérez Gallán Vania Prudencio Ribera Luis Puente Maestu Beatriz Recio Moreno Elena Rodríguez Jimeno Ana Sánchez Azofra José Ignacio de Granda-Orive 《Archivos de bronconeumologia》2021,57(2):146-147
35.
F Prats M Porta Serra H Yazbeck R Herrera J M Gassó 《Gaceta sanitaria / S.E.S.P.A.S》1990,4(20):179-183
OBJECTIVES: To estimate the prevalence of antibodies to human immunodeficiency virus (HIV), antibodies to hepatitis B core antigen (anti-HBc), hepatitis B surface antigen (HBsAg), and antibodies to delta virus (anti-DV). DESIGN: Cross-sectional (prevalence) study. A non-proportional (stratified by length of stay) random sample of 20% of admitted patients was selected. CLINICAL SETTING: The Hospital Psiquiátrico Nuestra Se?ora de Montserrat (Sant Boi de Llobregat, Barcelona, Spain) admits about 670 patients in its short-term, rehabilitation (mid-term) and long-term wards. SUBJECTS: 139 patients were selected: 91% were males, mean age was 55 years, and 10% belonged to an HIV risk group; mean length of hospitalization since last discharge was 13 years. MEASUREMENTS: Blood samples were drawn in October, 1988. Anti-HBc, HBsAg and anti-DV were determined by competitive enzyme immunoassay (EIA). Anti-HIV-1 were determined by sandwich EIA; negativity of results with high absorbency but below the cut-off point was confirmed by Western blot. RESULTS: None of the sampled patients had circulating anti-HIV-1 antibodies. Four cases showing high absorbency (below the "cut-off" point) were ruled out by Western-blot. Overall, the prevalence of anti-HBc was 52.8% (54.4% in long-term wards, 35.0% in mid-term wards, and 13.8% in short-term wards). The prevalence of HBsAg was 2.3%, of anti-DV 1.5%, and of HDAg 0%. CONCLUSIONS: Prevalence of anti-HIV is null in the studied institution. Current efforts to prevent HIV infection must continue; a hepatitis B vaccination program is highly warranted among patients and professionals of the studied hospital. 相似文献
36.
Joanna Luczkowiak Gonzalo Rivas Nuria Labiod Fátima Lasala Marta Rolo Jaime Lora-Tamayo Mikel Mancheno-Losa David Rial-Crestelo Alfredo Pérez-Rivilla María Dolores Folgueira Rafael Delgado 《Journal of medical virology》2023,95(1):e28268
We have measured the humoral response to messenger RNA (mRNA) vaccines in COVID-19 naïve and convalescent individuals. Third doses of mRNA COVID-19 vaccines induced a significant increase in potency and breadth of neutralization against SARS-CoV-2 variants of concern (VoC) including Omicron subvariants BA.1, BA.2, and BA.2.12.1, that were cross-neutralized at comparable levels and less for BA.4/5. This booster effect was especially important in naïve individuals that only after the third dose achieved a level that was comparable with that of vaccinated COVID-19 convalescents except for BA.4/5. Avidity of RBD-binding antibodies was also significantly increased in naïve individuals after the third dose, indicating an association between affinity maturation and cross neutralization of VoC. These results suggest that at least three antigenic stimuli by infection or vaccination with ancestral SARS-CoV-2 sequences are required to induce high avidity cross-neutralizing antibodies. Nevertheless, the circulation of new subvariants such as BA.4/5 with partial resistance to neutralization will have to be closely monitored and eventually consider for future vaccine developments. 相似文献
37.
Fourteen patients with metastatic colon cancer which had progressed under fluoro-folates chemotherapy were treated with MM-C (10 mg/m(2) on day 1), 5-FU (370 mg/m(2) for 5 consecutive days), l-LV (500 mg/m(2) for 5 consecutive days) and CDDP (70 mg/m(2) on day 4), every 29th day till further disease progression. Neither CR nor PR were observed; 3 patients only had stable disease, while the extant 11 patients progressed. Resulting toxicity was severe. Since no antitumor effects were evidenced in the first 14 patients, the study was discontinued according to commonly accepted criteria. 相似文献
38.
Porta F Lanfranchi A Verardi R Mazzolari E Verzeri U Tettoni K Ugazio AG 《Annali dell'Istituto superiore di sanità》1999,35(2):315-328
Primary immunodeficiencies are inherited diseases characterized by impaired immune responses. In case of severe impairment of immunity bone marrow transplantation is the only therapeutic option. The molecular defect is known for several primary immunodeficiencies allowing prenatal diagnosis. This paper summarizes the clinical experience treating these pathologies by bone marrow transplantation. 相似文献
39.
We report a new case of Wunderlich's syndrome (spontaneous perirenal hematoma) in a patient with chronic renal failure undergoing hemodialysis secondary to acquired renal cystic disease. The literature relative to this condition is review. 相似文献
40.
Although it is now possible to significantly reduce the incidence of blindness secondary to diabetes mellitus, large numbers of diabetic patients still experience visual loss due to retinal complications of the disease. This implies that protocols for the diagnosis and treatment of diabetic retinopathy used in the various multicenter trials have not yet been transferred into routine clinical practice. In countries where ocular complications of diabetes have been managed on the basis of well-codified protocols for several years, the incidence of visual loss among diabetic patients has been significantly reduced. It is absolutely essential to introduce screening and treatment protocols for diabetic retinopathy promptly everywhere. Their application is within the reach of every ophthalmologist. Patients must be informed that it is important to have regular full ophthalmological examinations, before any symptoms occur; the guidelines for screening and management of retinopathy must be known and accepted by the medical community. Spreading this information among primary care physicians, ophthalmologists and diabetologists is a fundamental step in improving the health care of the diabetic patient. 相似文献