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Co‐culture of adipose‐derived stem cells and chondrocytes on three‐dimensionally printed bioscaffolds for craniofacial cartilage engineering 下载免费PDF全文
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Utilizing time‐driven activity‐based costing to understand the short‐ and long‐term costs of treating localized,low‐risk prostate cancer 下载免费PDF全文
Aaron A. Laviana MD Annette M. Ilg BS Darlene Veruttipong MSE Hung‐Jui Tan MD Michael A. Burke MHA Douglas R. Niedzwiecki MBA MHA Patrick A. Kupelian MD Chris R. King MD Michael L. Steinberg MD Chandan R. Kundavaram MD Mitchell Kamrava MD Alan L. Kaplan MD Andrew K. Moriarity MD William Hsu PhD Daniel J. A. Margolis MD Christopher S. Saigal MD MPH 《Cancer》2016,122(3):447-455
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Todd M. Larabee Charles M. Little Balasundar I. Raju Eric Cohen-Solal Ramon Erkamp Scott Wuthrich John PetruzzelloMichael Nakagawa MSE Shervin Ayati 《The American journal of emergency medicine》2011,29(9):1141-1146
Objective
To determine if a hands-free, noninvasive Doppler ultrasound device can reliably detect low-flow cardiac output by measuring carotid artery blood flow velocities. We compared the ability of observers to detect carotid artery flow velocity differences between pseudo-pulseless electrical activity (PEA) and true-PEA cardiac arrest.Methods
Five swine were instrumented with aortic (Ao) and right atrial pressure-transducing catheters. The Doppler ultrasound device was adhered to the neck over the carotid artery. Continuous electrocardiogram, pressure readings, and Doppler signal were recorded. Each swine underwent multiple episodes of fibrillation and resuscitation. Episodes of true-PEA and pseudo-PEA were retrospectively identified from all resuscitation attempts by examination of electrocardiogram and Ao waveforms. The sensitivity and specificity of the device to detect pseudo-PEA was obtained using observers blinded to Ao waveform recordings.Results
There was good interobserver reliability related to identification of pseudo- and true-PEA (κ = 0.873). The observers blinded to Ao waveform recordings agreed on 8 of the 9 episodes of pseudo-PEA, whereas 4 false positives of 26 true-PEA events were reported (sensitivity, 0.89; specificity, 0.85). The Doppler device was able to detect carotid flow velocity over a wide range of Ao blood pressures.Conclusions
This hands-free, noninvasive Doppler ultrasound device can reliably differentiate pseudo-PEA from true-PEA during resuscitation from cardiac arrest, detecting pressure gradient changes of less than 5 mm Hg through to normotension. This device distinguishes conditions of no cardiac output from low cardiac output and may have applications for use during resuscitation from various etiologies of arrest and shock. 相似文献36.
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Sun Ju Chung MD PhD Sebastian M. Armasu MS Joanna M. Biernacka PhD Timothy G. Lesnick MS David N. Rider MSE Sarah J. Lincoln BS Alexandra I. Ortolaza Matthew J. Farrer PhD Julie M. Cunningham PhD Walter A. Rocca MD MPH Demetrius M. Maraganore MD 《Movement disorders》2011,26(2):280-288
Rare mutations in PARK loci genes cause Parkinson's disease (PD) in some families and isolated populations. We investigated the association of common variants in PARK loci and related genes with PD susceptibility and age at onset in an outbred population. A total of 1,103 PD cases from the upper Midwest, USA, were individually matched to unaffected siblings (n = 654) or unrelated controls (n = 449) from the same region. Using a sequencing approach in 25 cases and 25 controls, single nucleotide polymorphisms (SNPs) in species‐conserved regions of PARK loci and related genes were detected. We selected additional tag SNPs from the HapMap. We genotyped a total of 235 SNPs and two variable number tandem repeats in the ATP13A2, DJ1, LRRK1, LRRK2, MAPT, Omi/HtrA2, PARK2, PINK1, SNCA, SNCB, SNCG, SPR, and UCHL1 genes in all 2,206 subjects. Case‐control analyses were performed to study association with PD susceptibility, while cases‐only analyses were used to study association with age at onset. Only MAPT SNP rs2435200 was associated with PD susceptibility after correction for multiple testing (OR = 0.74, 95% CI = 0.64–0.86, uncorrected P < 0.0001, log additive model); however, 16 additional MAPT variants, seven SNCA variants, and one LRRK2, PARK2, and UCHL1 variants each had significant uncorrected P‐values. There were no significant associations for age at onset after correction for multiple testing. Our results confirm the association of MAPT and SNCA genes with PD susceptibility but show limited association of other PARK loci and related genes with PD. © 2010 Movement Disorder Society 相似文献
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Scott B. Reeder MD PhD Philip M. Robson PhD Huanzhou Yu PhD Ann Shimakawa MSE Catherine DG Hines MS Charles A. McKenzie PhD Jean H. Brittain PhD 《Journal of magnetic resonance imaging : JMRI》2009,29(6):1332-1339