全文获取类型
收费全文 | 5680篇 |
免费 | 456篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 49篇 |
儿科学 | 119篇 |
妇产科学 | 101篇 |
基础医学 | 668篇 |
口腔科学 | 67篇 |
临床医学 | 758篇 |
内科学 | 1161篇 |
皮肤病学 | 93篇 |
神经病学 | 473篇 |
特种医学 | 162篇 |
外科学 | 979篇 |
综合类 | 44篇 |
一般理论 | 3篇 |
预防医学 | 502篇 |
眼科学 | 86篇 |
药学 | 426篇 |
中国医学 | 7篇 |
肿瘤学 | 448篇 |
出版年
2023年 | 57篇 |
2022年 | 37篇 |
2021年 | 311篇 |
2020年 | 180篇 |
2019年 | 243篇 |
2018年 | 269篇 |
2017年 | 190篇 |
2016年 | 165篇 |
2015年 | 250篇 |
2014年 | 256篇 |
2013年 | 364篇 |
2012年 | 461篇 |
2011年 | 490篇 |
2010年 | 236篇 |
2009年 | 164篇 |
2008年 | 291篇 |
2007年 | 278篇 |
2006年 | 298篇 |
2005年 | 216篇 |
2004年 | 206篇 |
2003年 | 185篇 |
2002年 | 156篇 |
2001年 | 80篇 |
2000年 | 65篇 |
1999年 | 63篇 |
1998年 | 33篇 |
1997年 | 30篇 |
1996年 | 31篇 |
1995年 | 30篇 |
1994年 | 12篇 |
1993年 | 19篇 |
1992年 | 44篇 |
1991年 | 41篇 |
1990年 | 41篇 |
1989年 | 33篇 |
1988年 | 28篇 |
1987年 | 27篇 |
1986年 | 24篇 |
1985年 | 32篇 |
1984年 | 27篇 |
1983年 | 12篇 |
1979年 | 15篇 |
1978年 | 9篇 |
1974年 | 11篇 |
1973年 | 13篇 |
1971年 | 13篇 |
1970年 | 12篇 |
1968年 | 14篇 |
1967年 | 8篇 |
1966年 | 13篇 |
排序方式: 共有6146条查询结果,搜索用时 279 毫秒
81.
Kyle D. Ketchesin Darius Becker‐Krail Colleen A. McClung 《The European journal of neuroscience》2020,51(1):326-345
Mood disorders, including major depression, bipolar disorder, and seasonal affective disorder, are debilitating disorders that affect a significant portion of the global population. Individuals suffering from mood disorders often show significant disturbances in circadian rhythms and sleep. Moreover, environmental disruptions to circadian rhythms can precipitate or exacerbate mood symptoms in vulnerable individuals. Circadian clocks exist throughout the central nervous system and periphery, where they regulate a wide variety of physiological processes implicated in mood regulation. These processes include monoaminergic and glutamatergic transmission, hypothalamic–pituitary–adrenal axis function, metabolism, and immune function. While there seems to be a clear link between circadian rhythm disruption and mood regulation, the mechanisms that underlie this association remain unclear. This review will touch on the interactions between the circadian system and each of these processes and discuss their potential role in the development of mood disorders. While clinical studies are presented, much of the review will focus on studies in animal models, which are attempting to elucidate the molecular and cellular mechanisms in which circadian genes regulate mood. 相似文献
82.
83.
Aaron S. Farberg Mary A. Hall Leah Douglas Kyle R. Covington Sarah J. Kurley Robert W. Cook 《Current medical research and opinion》2020,36(8):1301-1307
AbstractObjective: To integrate gene expression profiling into the management of high-risk cutaneous squamous cell carcinoma (cSCC) within the National Comprehensive Cancer Network (NCCN) guidelines to improve risk-aligned management recommendations.Methods: A cohort of 300 NCCN-defined high-risk cSCC patients, along with the American Joint Committee on Cancer (AJCC) T stage, Brigham and Women’s Hospital (BWH) T stage, and known patient outcomes were analyzed. Risk classifications using a validated 40-gene expression profile (40-GEP) test and T stage were applied to NCCN patient management guidelines. Risk-directed patient management recommendations within the NCCN guidelines framework were aligned based on risk for metastasis.Results: Of the 300 NCCN high-risk cSCC patients, 159 (53.0%) were 40-GEP Class 1 and AJCC T1-T2, and 173 (57.7%) were Class 1 and BWH T1-2a, indicating low risk for metastasis and, thereby, suggesting low management intensity. The 40-GEP integration suggested high intensity management for only 24 (8.0%) patients (all Class 2B), and moderate intensity management for the remainder of the cohort.Conclusions: The 40-GEP test can be integrated within existing NCCN guideline recommendations for managing cSCC patients to help refine risk-directed management decisions. Integration of the 40-GEP test would allow >50% of this NCCN-defined high-risk cohort to be managed with the lowest intensity recommendations within the broad NCCN guidelines. High intensity management was deemed risk-appropriate for a small subpopulation (8.0%). This study demonstrates that the 40-GEP test, in combination with T stage, has clinical utility to impact patient management decisions in NCCN high-risk cSCC for improving risk-aligned management within the NCCN guidelines framework. 相似文献
84.
85.
Lu Victor M. O’Connor Kyle P. Shah Ashish H. Eichberg Daniel G. Luther Evan M. Komotar Ricardo J. Ivan Michael E. 《Journal of neuro-oncology》2020,148(2):221-229
Journal of Neuro-Oncology - The most recent cIMPACT-NOW update highlighted the homozygous deletion of the Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) gene as a clinically important molecular... 相似文献
86.
87.
Xiaowen Liu Danwen Qian Hongliang Liu James L. Abbruzzese Sheng Luo Kyle M. Walsh Qingyi Wei 《Molecular carcinogenesis》2020,59(8):930-939
Because the peroxisome proliferator-activated receptor (PPAR) signaling pathway is involved in development and progression of pancreatic cancer, we investigated associations between genetic variants of the PPAR pathway genes and pancreatic cancer risk by using three published genome-wide association study datasets including 8477 cases and 6946 controls of European ancestry. Expression quantitative trait loci (eQTL) analysis was also performed for correlations between genotypes of the identified genetic variants and messenger RNA (mRNA) expression levels of their genes by using available databases of the 1000 Genomes, TCGA, and GTEx projects. In the single-locus logistic regression analysis, we identified 1141 out of 17 532 significant single-nucleotide polymorphisms (SNPs) in 112 PPAR pathway genes. Further multivariate logistic regression analysis identified three independent, potentially functional loci (rs12947620 in MED1, rs11079651 in PRKCA, and rs34367566 in PRKCB) for pancreatic cancer risk (odds ratio [OR] = 1.11, 95% confidence interval [CI], [1.06-1.17], P = 5.46 × 10−5; OR = 1.10, 95% CI, [1.04-1.15], P = 1.99 × 10−4; and OR = 1.09, 95% CI, [1.04-1.14], P = 3.16 × 10−4, respectively) among 65 SNPs that passed multiple comparison correction by false discovery rate (< 0.2). When risk genotypes of these three SNPs were combined, carriers with 2 to 3 unfavorable genotypes (NUGs) had a higher risk of pancreatic cancer than those with 0 to 1 NUGs. The eQTL analysis showed that rs34367566 A>AG was associated with decreased expression levels of PRKCB mRNA in 373 lymphoblastoid cell lines. Our findings indicate that genetic variants of the PPAR pathway genes, particularly MED1, PRKCA, and PRKCB, may contribute to susceptibility to pancreatic cancer. 相似文献
88.
Alexander Ayala Kyle Tegtmeyer Giancarlo Atassi Elizabeth Powell 《The Journal of emergency medicine》2021,60(5):661-668
BackgroundProlonged emergency department (ED) wait times could potentially lead to increased morbidity and mortality. While previous work has demonstrated disparities in wait times associated with race, information about the relationship between experiencing homelessness and ED wait times is lacking.ObjectivesThe purpose of this study was to explore the relationship between residence status (undomiciled vs. domiciled) and ED wait times. We hypothesized that being undomiciled would be associated with longer wait times.MethodsWe obtained data from the National Hospital Ambulatory Medical Care Survey from 2014 to 2017. We compared wait times in each triage category using t tests. We used multivariate linear regression to explore associations between residence status and wait times while controlling for other patient- and hospital-level variables.ResultsOn average, undomiciled patients experienced significantly longer mean ED wait times than domiciled patients (53.4 vs. 38.9 min; p < 0.0001). In the multivariate model, undomiciled patients experienced significantly different wait times by 15.5 min (p = 0.0002). Undomiciled patients experienced increasingly longer waits vs. domiciled patients for the emergent and urgent triage categories (+33.5 min, p < 0.0001, and +22.7 min, p < 0.0001, respectively).ConclusionsUndomiciled patients experience longer ED wait times when compared with domiciled patients. This disparity is not explained by undomiciled patients seeking care in the ED for minor illness, because the disparity is more pronounced for urgent and emergent triage categories. 相似文献
89.
Ticiana A. Leal Angela C. Argento Krish Bhadra D. Kyle Hogarth Julia Grigorieva Rachel M. Hartfield 《Current medical research and opinion》2020,36(9):1497-1505
Abstract
Objective
Timely assessment of patient-specific prognosis is critical to oncology care involving a shared decision-making approach, but clinical prognostic factors traditionally used in NSCLC have limitations. We examine a proteomic test to address these limitations. 相似文献90.
Nicole Bohm Charles Makowski Mario Machado Adam Davie Nelson Seabrook Lee Wheless Benjamin Bevill Bradley Clark T. Rogers Kyle III 《Antimicrobial agents and chemotherapy》2014,58(8):4902-4903
A patient receiving daptomycin developed asymptomatic transaminitis and hyperbilirubinemia without concurrent multiorgan dysfunction or elevation of his creatinine kinase level. After ruling out other etiologies, the liver injury was attributed to daptomycin and was subsequently resolved. A single-center retrospective cohort analysis of baseline and follow-up liver function panels (n = 614) from all admissions from 2008 to 2013 during which daptomycin was administered did not reveal any other cases of probable or definite drug-induced liver injury associated with daptomycin. 相似文献