全文获取类型
收费全文 | 1449篇 |
免费 | 132篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 87篇 |
妇产科学 | 23篇 |
基础医学 | 149篇 |
口腔科学 | 99篇 |
临床医学 | 156篇 |
内科学 | 319篇 |
皮肤病学 | 55篇 |
神经病学 | 39篇 |
特种医学 | 267篇 |
外科学 | 158篇 |
综合类 | 20篇 |
预防医学 | 88篇 |
眼科学 | 7篇 |
药学 | 65篇 |
肿瘤学 | 71篇 |
出版年
2021年 | 10篇 |
2020年 | 7篇 |
2019年 | 18篇 |
2018年 | 39篇 |
2017年 | 22篇 |
2016年 | 14篇 |
2015年 | 18篇 |
2014年 | 23篇 |
2013年 | 20篇 |
2012年 | 23篇 |
2011年 | 29篇 |
2010年 | 43篇 |
2009年 | 34篇 |
2008年 | 33篇 |
2007年 | 45篇 |
2006年 | 49篇 |
2005年 | 32篇 |
2004年 | 31篇 |
2003年 | 42篇 |
2002年 | 37篇 |
2001年 | 27篇 |
2000年 | 33篇 |
1999年 | 28篇 |
1998年 | 70篇 |
1997年 | 78篇 |
1996年 | 85篇 |
1995年 | 55篇 |
1994年 | 43篇 |
1993年 | 47篇 |
1992年 | 31篇 |
1991年 | 35篇 |
1990年 | 39篇 |
1989年 | 62篇 |
1988年 | 56篇 |
1987年 | 53篇 |
1986年 | 40篇 |
1985年 | 46篇 |
1984年 | 16篇 |
1983年 | 16篇 |
1982年 | 18篇 |
1981年 | 18篇 |
1980年 | 19篇 |
1979年 | 17篇 |
1978年 | 13篇 |
1977年 | 19篇 |
1976年 | 14篇 |
1975年 | 12篇 |
1971年 | 6篇 |
1970年 | 9篇 |
1968年 | 5篇 |
排序方式: 共有1609条查询结果,搜索用时 15 毫秒
51.
52.
Cutaneous histoplasmosis with prominent parasitization of epidermal keratinocytes: report of a case 下载免费PDF全文
Hedieh H. Honarpisheh Jonathan L. Curry Kristen Richards Priyadharsini Nagarajan Phyu P. Aung Carlos A. Torres‐Cabala Doina Ivan Carol R. Drucker Richard Cartun Victor G. Prieto Michael T. Tetzlaff 《Journal of cutaneous pathology》2016,43(12):1155-1160
Disseminated histoplasmosis most commonly occurs in immunosuppressed individuals and involves the skin in approximately 6% of patients. Cutaneous histoplasmosis with an intraepithelial‐predominant distribution has not been described. A 47‐year‐old man was admitted to our institution with fever and vancomycin‐resistant enterococcal bacteremia. He had been diagnosed with T‐cell prolymphocytic leukemia 4 years earlier and had undergone matched‐unrelated‐donor stem cell transplant 2 years earlier; on admission, he had relapsed disease. His medical history was significant for disseminated histoplasmosis 6 months before admission, controlled with multiple antifungal regimens. During this final hospitalization, the patient developed multiple 2–5 mm erythematous papules, a hemorrhagic crust across the chest, shoulders, forearms, dorsal aspect of the fingers, abdomen and thighs. Skin biopsy revealed clusters of oval yeast forms mostly confined to the cytoplasm of keratinocytes and within the stratum corneum; scattered organisms were present in the underlying superficial dermis without any significant associated inflammatory infiltrate. Special stains and immunohistochemical studies confirmed these to be Histoplasma organisms. We highlight this previously unrecognized pattern of cutaneous histoplasmosis to ensure its prompt recognition and appropriate antifungal therapy. 相似文献
53.
54.
D.O. Croitoru Y. Huang A. Kurdina A.-W. Chan A-M. Drucker 《The British journal of dermatology》2020,182(6):1469-1476
Systematic reviews (SRs) are considered the gold-standard for putting together evidence in healthcare. They serve clinicians and other stakeholders of the healthcare field, such as patients and policy makers, by summarizing the available data that we have on a medical subject, while highlighting the quality of the studies existing in the literature. In literature from other medical specialties, the use of reporting guidelines, such as the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA), has been shown to increase transparency and reproducibility (the extent to which consistent results are obtained when an experiment is repeated). To date, however, no studies have looked at how well dermatology SRs adhere to items from the PRISMA guideline, which is what the authors of this study, based in Canada, aimed to address. It is important that the methodology of systematic reviews is transparent and appropriately reported, so that readers have a clear understanding of what was done and why. To do this, we reviewed all SRs published in the five dermatology journals with the highest impact factors from 2013 to 2017. We evaluated how well selected PRISMA items were reported and whether the adherence of reporting was associated with factors such as year of publication, protocol registration, and funding source. We found that among SRs published in five dermatology journals from 2013-17, all (136 of 136) had at least one inadequately reported PRISMA item, while 93% (127 of 136) had at least one fully non-reported item. Reporting improved over time and SRs that stated they used a pre-registered protocol were associated with better reporting of the PRISMA items we assessed. Several items remain commonly under-reported in dermatology systematic reviews and we identified these in the hopes that it improves reporting going forward. With the results from this study, we feel that authors, reviewers, journal editors and editorial committees should strive to encourage pre-registration of SR protocols and better SR reporting. This is a summary of the study: Quality of reporting in systematic reviews published in dermatology journals 相似文献
55.
56.
57.
58.
Interleukin-1 alpha (IL-1 alpha) is a macrophage-derived, multifunctional cytokine that broadly potentiates myelopoiesis and induces the synthesis of hematopoietic colony-stimulating factors (CSF) in vitro and in vivo. To evaluate the possibility for use of IL-1 alpha in ameliorating in vivo bone marrow suppression induced by drugs or radiation, we examined the in vivo effects of the cytokine on erythropoietic and other hematopoietic progenitor cells. Normal mice were treated with a single intraperitoneal (IP) injection of recombinant human IL-1 alpha at varying doses and were assayed at various times post-treatment. By six hours postinjection, a significant suppression of mature erythroid progenitors (CFU-E) was observed in animals treated with IL-1 alpha (0.5 micrograms/mouse), with maximum suppression of CFU-E and peripheral blood reticulocyte counts occurring at 24 hours. Decreases in peripheral blood hematocrit did not occur after a single IL-1 alpha injection but were observed after multiple injections of the cytokine. The suppressive effects of IL-1 alpha on late-stage erythropoiesis were abrogated by simultaneous administration of erythropoietin (EPO). At 48 hours post-treatment, a marked stimulation was observed in the numbers of spleen and marrow immature erythroid (BFU-E), macrophage (CFU-M), granulocyte (CFU-G), granulocyte- macrophage (CFU-GM), and megakaryocyte (CFU-meg) progenitor cells. These results demonstrate the potential use of IL-1 alpha as a generalized stimulator of hematopoiesis and show that the cytokine- induced suppression of late-stage erythropoiesis can be prevented by EPO. 相似文献
59.
60.
EH Gemmill DJ Humes JA Catton 《Annals of the Royal College of Surgeons of England》2015,97(3):173-179