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41.
Maksić J Raicević R Obradović D Rajsić N Popović S Vladejić S 《Vojnosanitetski pregled. Military-medical and pharmaceutical review》2003,60(2):233-236
This paper presents a case of a sixteen-year-old female patient with agenesis of corpus callosum which was accidentally discovered during etiological investigation of the consciousness disorder. Agenesis of corpus callosum, a rare congenital defect, might be associated with macrocephalia and various degrees of mental impairment, optic defects, and seizures. Apart from patients with these pathologic states, there are individuals with agenesis of corpus callosum, but without any clinical disturbances. 相似文献
42.
Zoran Vukasinovic Dusko Spasovski Cedomir Vucetic Goran Cobeljic Zorica Zivkovic Dragana Matanovic 《International orthopaedics》2009,33(5):1377-1383
This article presents the results of Legg-Calve-Perthes (LCP) disease treatment using triple pelvic osteotomy. Thirty patients
were analysed. The conditions for inclusion in the study were complete medical documentation and follow-up until the disease
was resolved. Postoperatively, no patients were immobilised. Rehabilitation was initiated early in all patients, and full
weight bearing was allowed after ten weeks. With this method, an increase of the CE angle of 17.43 ± 4.020° was achieved.
Containment was increased from an initial 6.67% to 53.33% of patients at the final check-up. Similar improvement was achieved
by using Herring classification of the damage; preoperatively most hips belonged to group C, and postoperatively to group
A. Postoperatively, functional results were also considerably improved. The authors recommend triple pelvic osteotomy as the
method of choice in the treatment of severe cases of LCP disease. 相似文献
43.
Single visit reconstruction of the fractured crown can be completed with composite resins if there is no bleeding due to the soft tissue injury. Clinical inspection revealed a complex crown fracture of the central incisor as well as a simple horizontal fracture of the lateral incisor crown of the enamel-dentin type. Vertical fracture separated the palatal enamel wall from the rest of the lateral incisor crown. After the completion of the endodontic sanitation, root canals were prepared for prefabricated composite posts and crown reconstructions were performed with the Finger Tip Technique by using composite resin materials. The advantage of this kind of reconstruction is preservation of the hard dental crown tissue removed in case of prosthetic therapy, especially in younger patients. Reconstruction can be finished in one visit, without the need for a dental technician and laboratory. 相似文献
44.
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46.
Amifampridine phosphate (Firdapse®) is effective and safe in a phase 3 clinical trial in LEMS
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Shin J Oh MD Natalya Shcherbakova MD Anna Kostera‐Pruszczyk MD PhD Mohammad Alsharabati MD Mazen Dimachkie MD Jose Munoz Blanco MD Thomas Brannagan MD Dragana Lavrnić MD PhD Perry B Shieh MD PhD Christophe Vial MD Andreas Meisel MD Samuel Komoly MD PhD DSc Benedikt Schoser MD Kumaraswamy Sivakumar MD Yuen So MD PhD LEMS Study Group 《Muscle & nerve》2016,53(5):717-725
47.
Philip Urban MD Dragana Radovanovic MD Paul Erne MD Jean-Christophe Stauffer MD Giovanni Pedrazzini MD Stephan Windecker MD Osmund Bertel MD AMIS Plus investigators 《The American journal of medicine》2008,(12):1065-1071
Background
To assess the impact of the new definitions of myocardial infarction, we retrospectively analyzed 9190 patients from 63 hospitals with reported peak troponin values included between 2001 and 2007 in the Swiss AMIS (Acute Myocardial Infarction in Switzerland) Plus registry.Methods
Patients were classified as belonging to the “classic” myocardial infarction group (peak total CK or CK-MB above the upper limit of normal, or troponin T [TnT] >0.1 μg/L or troponin I [TnI] >0.1-0.8 μg/L [depending on the assay]) or “new” myocardial infarction group (TnT >0.01 μg/L or TnI >0.01-0.07 μg/L).Results
There were 489 patients in the “new” group who were similar to the 8701 “classic” patients in terms of age, sex, and prevalence of both diabetes and renal failure, but more frequently had a history of prior coronary artery disease, hypertension, and hyperlipidemia. At admission, they less frequently had ST elevation on their electrocardiogram, were more frequently in Killip class I, and received less primary percutaneous coronary intervention. Hospital mortality was 3.5% in the “new” and 6.7% in the “classic” myocardial infarction group (P = .004). In a subset of patients with a longer follow-up, mortality at 3 and 12 months was 1% and 5.6%, respectively, for “new” and 1.6% and 4%, respectively, for “classic” myocardial infarction (NS).Conclusions
Patients with minimal elevation of serum troponin have smaller infarctions, less aggressive treatment, fewer early complications, and a better early prognosis than patients with higher serum biomarker levels. After discharge, however, their prognosis currently appears no different from that of patients with a “classic” myocardial infarction event. 相似文献48.
Analysis of the third‐ and fourth‐generation cephalosporin use for the treatment of infections caused by Gram‐negative bacteria in hospital settings
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49.
Milović M Djuriš J Djekić L Vasiljević D Ibrić S 《International journal of pharmaceutics》2012,436(1-2):58-65
The purpose of this study was to investigate solid self-microemulsifying drug delivery system (SSMEDDS), as potential delivery system for poorly water soluble drug carbamazepine (CBZ). Self-microemulsifying drug delivery system (SMEDDS) was formulated using the surfactant polyoxyethylene 20 sorbitan monooleate [Polysorbate 80] (S), the cosurfactant PEG-40 hydrogenated castor oil [Cremophor(?) RH40] (C) and the oil caprylic/capric triglycerides [Mygliol(?) 812] (O). Four different adsorbents with high specific surface area were used: Neusilin(?) UFL2, Neusilin(?) FL2 (magnesium aluminometasilicate), Sylysia(?) 320 and Sylysia(?) 350 (porous silica). Microemulsion area at the surfactant to cosurfactant ratio (K(m)) 1:1 was evaluated and for further investigation SMEDDS with SC/O ratio 8:2 was selected. Solubilization capacity of selected SMEDDS for CBZ was 33.771±0.041mg/ml. Rheological measurements of unloaded and CBZ-loaded SMEDDS at water content varied from 10 to 60% (w/w) were conducted. It has been found that CBZ has great influence on rheological behaviour of investigated system upon water dilution. Photon correlation spectroscopy has shown the ability of CBZ-loaded SMEDDS to produce microemulsion droplet size. SSMEDDS improved release rate of CBZ, but the type of adsorbent significantly affects release rate of CBZ. For SSMEDDS with different magnesium aluminometasilicate adsorbents, release rate of CBZ decreased with increasing specific surface area due to entrapment of liquid SMEDDS inside the pores and its gradual exposure to dissolution medium. With porous silica adsorbents no difference in release rate was found in comparison to physical mixtures. In physical mixtures at 12.5% (w/w) CBZ content, presence of amorphous CBZ led to high dissolution rate. 相似文献
50.
Šarenac O Lozić M Drakulić S Bajić D Paton JF Murphy D Japundžić-Žigon N 《Experimental physiology》2011,96(6):574-589
This study investigates blood pressure (BP) and heart rate (HR) short-term variability and spontaneous baroreflex functioning in adult borderline hypertensive rats and normotensive control animals kept on normal-salt diet. Arterial pulse pressure was recorded by radio telemetry. Systolic BP, diastolic BP and HR variabilities and baroreflex were assessed by spectral analysis and the sequence method, respectively. In all experimental conditions (baseline and stress), borderline hypertensive rats exhibited higher BP, increased baroreflex sensitivity and resetting, relative to control animals. Acute shaker stress (single exposure to 200 cycles min-1 shaking platform) increased BP in both strains, while chronic shaker stress (3-day exposure to shaking platform) increased systolic BP in borderline hypertensive rats alone. Low- and high-frequency HR variability increased only in control animals in response to acute and chronic shaker (single exposure to restrainer) stress. Acute restraint stress increased BP, HR, low- and high-frequency variability of BP and HR in both strains to a greater extent than acute shaker stress. Only normotensive rats exhibited a reduced ratio of low- to high-frequency HR variability, pointing to domination of vagal cardiac control. In borderline hypertensive rats, but not in control animals, chronic restraint stress (9-day exposure to restrainer) increased low- and high-frequency BP and HR variability and their ratio, indicating a shift towards sympathetic cardiovascular control. It is concluded that maintenance of BP in borderline hypertensive rats in basal conditions and during stress is associated with enhanced baroreflex sensitivity and resetting. Imbalance in sympathovagal control was evident only during exposure of borderline hypertensive rats to stressors. 相似文献