氨溴索预先给药对单肺通气患者炎性反应及脂质过氧化反应的影响

Objective To investigate the effect of ambroxol pretreatment on the inflammatory response and lipid peroxidation during one-lung ventilation (OLV) .Methods Forty-five ASA I or II patients aged 37-64 yr weighing 53-65 kg undergoing thoracotomy under general anesthesia were randomly divided into 3 groups ( n = 15 each): group A two-lung ventilation (TLV); group B OLV and group C ambroxol 1 mg/kg + OLV. Anesthesia was induced with midazolam, fentanyl, propofol and atracurium and maintained with propofol infusion and intermittent iv boluses of fentanyl and atracurium. The patients were mechanically ventilated (VT8-10 ml/kg, RR 12 bpm during TLV, VT 6-7 ml/kg, RR 16 bpm during OLV, I: E 1:2, FiO2 100% ). In group C ambroxol 1 mg/kg in normal saline ( NS) 100 ml was infused at 25 min before OLV (infusion rate 4 ml/min) , while in group A and B equal volume of NS was infused instead of ambroxol. Blood samples were obtained from radial artery before induction of anesthesia and OLV (T0.1 ) and at 0.5, 1, 2 h of OLV (T2-4 ) and 1, 2 h of TLV (T5,6 ) and at 24 h after operation (T7) in group B and C for determination of serum SOD activity and TNF-α, IL-6 and IL-8 concentrations and WBC and neutrophil granulocyte counts. The same indexes were detected in group A at the corresponding time points.Results Serum SOD activity was significantly lower and serum TNF-α, IL-6 and IL-8 concentrations and WBC and neutrophil granulocyte counts were significantly higher in group B than in group A. Serum SOD activity was significantly higher and serum TNF-a, IL-6 and IL-8 concentrations and WBC and neutrophil granulocyte counts were significantly lower in group C than in group B. Conclusion Pretreatment with ambroxol 1 mg/kg can inhibit inflammatory response and lipid peroxidation during OLV.     

不同浓度布比卡因椎旁阻滞用于剖胸术后镇痛的临床研究

目的:观察不同浓度布比卡因椎旁阻滞用于剖胸术后镇痛效果和给药方式.方法:90例全麻下单侧剖胸手术病人,随机分为6组(n=15).术后病人出现中度疼痛时,用不同浓度布比卡因椎旁阻滞作镇痛治疗,Ⅰ～Ⅵ组布比卡因浓度依次为0.13%、0.20%、0.25%、0.30%、0.37%、0.50%,首量15 ml.观察镇痛前、后的血压、心率、SpO2、疼痛评分、呼吸通气功能的变化及部分病例的应激激素变化.再次出现疼痛时注药,此时第Ⅰ～Ⅳ组用连续注射法,维持量2～4 ml/h;Ⅴ、Ⅵ组用间断注药法,每次15 ml. 结果:6组都有镇痛作用.Ⅰ～Ⅵ组的止痛时间依次为:(125±42) min、(167±39) min、(198±56) min、(215±67) min、(263±47) min、(452±75) min;疼痛评分:VAS评分≤4, Prince Henry Scale 评分≤2分;用布比卡因前及用后5、10、15、30 min的血压、心率、SpO2均无明显变化(P＞0.05);镇痛后30 min呼吸功能FVC、FEV1.0比镇痛前改善(P＜0.01);术后第1天促肾上腺皮质激素(ACTH)和皮质醇(COR)恢复麻醉前水平(P＞0.05). 结论:6种浓度布比卡因椎旁阻滞用于剖胸术后镇痛均有效、安全,止痛时间随浓度增加而延长, 0.13%布比卡因是实用有效的浓度.连续注射法比间断注射法效果更好.     

经胸膜穿刺置管行椎旁阻滞的可行性探讨

我们采用经胸膜穿刺置管的方法行椎旁阻滞用于单侧剖胸术后镇痛,效果满意。现报道如下。 资料与方法 单侧剖胸术患者40例,男29例,女11例,年龄17-68(54.2±13.6)岁,体重46-74(59.1±10.3)kg。手术为食管癌根治、肺叶切除、纵膈肿瘤切除、外伤性肺破裂修补术等     

超声引导下神经阻滞复合喉罩全麻在老年髋关节置换术患者中的应用优势评价

目的分析评价超声引导下神经阻滞复合喉罩全麻在老年髋关节置换手术(THA)患者中的应用效果。方法前瞻性选取2016年7月至2018年10月广西医科大学第三附属医院收治的择期行单侧THA的老年患者(65～80岁) 70例,以随机数字表法分为超声引导组、常规组各35例,前者实施超声引导下神经阻滞复合喉罩全身麻醉,后者实施常规静吸复合全麻气管插管。统计麻醉、手术相关数据,血流动力学监测数据,镇痛药物、肌肉松弛药物使用剂量,并评估镇痛效果及安全性。结果与常规组相比,超声引导组术后苏醒时间、拔管时间及恢复室停留时间明显短(P 0. 05)。超声引导组手术切皮时、假体植入时、手术切口关闭时、喉罩取出时(MAP)、心率(HR)逐渐接近于麻醉前基线水平,且整体上波动幅度较常规组更小(P 0. 05)。与常规组相比,超声引导组术中术中镇痛类药使用量,肌松类药使用量及术后自控静脉镇痛用药量均显著减少(P 0. 05),术后2 h、6 h、12 h、24 h视觉模拟评分(VAS)均显著低(P 0. 05)。超声引导组不良反应发生率略低于常规组(17. 41%vs 31. 43%),但无统计学差异(P 0. 05)。结论超声引导下神经阻滞复合喉罩全身麻醉具有麻醉效果好、镇痛效果满意、血流动力学平稳、镇痛药物用药量少、安全性高等优势,适用于老年THA患者。     

穴位注射配合乌梅丸治疗原发性痛经疗效观察

目的:观察穴位注射配合乌梅丸治疗原发性痛经的临床疗效.方法:将358例原发性痛经患者随机分为穴位注射配合乌梅丸组(A组)、乌梅丸组(B组)、穴位注射组(C组)和布洛芬组(D组)进行治疗,比较4组临床效果.结果:A组和C组总有效率接近,均高于B组和D组(P＜0.05),而A组治愈率高于C组,差异有统计学意义(P＜0.05).A组和C组治疗起效快,高于其他两组,差异有统计学意义(P＜0.05).结论:穴位注射配合乌梅丸治疗原发性痛经效果好,值得推广.     

氨溴索预先给药对单肺通气患者炎性反应及脂质过氧化反应的影响

Objective To investigate the effect of ambroxol pretreatment on the inflammatory response and lipid peroxidation during one-lung ventilation (OLV) .Methods Forty-five ASA I or II patients aged 37-64 yr weighing 53-65 kg undergoing thoracotomy under general anesthesia were randomly divided into 3 groups ( n = 15 each): group A two-lung ventilation (TLV); group B OLV and group C ambroxol 1 mg/kg + OLV. Anesthesia was induced with midazolam, fentanyl, propofol and atracurium and maintained with propofol infusion and intermittent iv boluses of fentanyl and atracurium. The patients were mechanically ventilated (VT8-10 ml/kg, RR 12 bpm during TLV, VT 6-7 ml/kg, RR 16 bpm during OLV, I: E 1:2, FiO2 100% ). In group C ambroxol 1 mg/kg in normal saline ( NS) 100 ml was infused at 25 min before OLV (infusion rate 4 ml/min) , while in group A and B equal volume of NS was infused instead of ambroxol. Blood samples were obtained from radial artery before induction of anesthesia and OLV (T0.1 ) and at 0.5, 1, 2 h of OLV (T2-4 ) and 1, 2 h of TLV (T5,6 ) and at 24 h after operation (T7) in group B and C for determination of serum SOD activity and TNF-α, IL-6 and IL-8 concentrations and WBC and neutrophil granulocyte counts. The same indexes were detected in group A at the corresponding time points.Results Serum SOD activity was significantly lower and serum TNF-α, IL-6 and IL-8 concentrations and WBC and neutrophil granulocyte counts were significantly higher in group B than in group A. Serum SOD activity was significantly higher and serum TNF-a, IL-6 and IL-8 concentrations and WBC and neutrophil granulocyte counts were significantly lower in group C than in group B. Conclusion Pretreatment with ambroxol 1 mg/kg can inhibit inflammatory response and lipid peroxidation during OLV.     

氨溴索预先给药对兔单肺通气时肺损伤的影响

目的 评价氨溴索预先给药对兔单肺通气时肺损伤的影响.方法 家兔67只随机分为4组,麻醉下气管插管,机械通气,A组(n=18)持续双肺通气4 h,B组(n=16)、C组(n=15)和D组(n=18)单肺通气2 h后恢复双肺通气2 h,C组和D组在单肺通气前分别静脉注射氨溴索5、15 mg/kg(生理盐水稀释至20 ml),B组给予等容量生理盐水.分别于麻醉前(基础状态)、单肺通气1、2 h、恢复双肺通气1、2 h时采集静脉血样,测定血清超氧化物歧化酶(SOD)活性、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和IL-8浓度,进行白细胞(WBC)计数和中性粒细胞计数,最后一次采集血样后,处死动物,取双侧肺组织,光镜下观察肺组织病理学.结果 与A组比较,B组、C组和D组SOD活性降低,TNF-α、IL-6、IL-8、WBC计数和中性粒细胞计数升高(P<0.05或0.01).与B组比较,C组和D组SOD活性升高,TNF-α、IL-6、IL-8、WBC计数和中性粒细胞计数降低(P<0.05或0.01).C组和D组间上述指标差异无统计学意义(P>0.05).A组双侧肺组织未见明显损伤;C组和D组非通气侧肺组织损伤轻于B组.结论 静脉注射氨溴索5、15 mg/kg可减轻单肺通气诱发兔肺损伤,其机制与抑制炎性反应及脂质过氧化反应有关.     

异丙酚复合芬太尼麻醉用于人工流产术3006例

我院2000年8月至2003年1月采用异丙酚复合芬太尼麻醉施行无痛人工流产术(人流术)3006例．效果满意．现总结报道如下。