注射用氯诺昔康与头孢硫脒注射剂体外配伍稳定性研究

目的考察室温条件下注射用氯诺昔康与头孢硫脒在氯化钠注射液(生理盐水)中的配伍稳定性。方法采用高效液相色谱法测定氯诺昔康与头孢硫脒配伍后8 h内各时间点的含量,同时测定pH值并观察配伍液的外观变化。结果 8 h内配伍液的含量、pH及外观均无明显变化。结论室温条件下,注射用氯诺昔康与头孢硫脒在生理盐水中8 h内保持稳定。     

丹红注射液与5种溶媒配伍分析

目的：探讨丹红注射液与不同溶媒配伍时不溶性微粒及pH的变化,选择最适宜与丹红注射液配伍的溶媒。方法：分别将丹红注射液加入0．9％氯化钠注射液（0．9％NS）、5％葡萄糖注射液（5％GS）、10％葡萄糖注射液（10％GS）、复方氯化钠注射液（Rs）和转化糖配成临床常用浓度,测定微粒数及pH,以验证丹红注射液说明书提供的用法。结果：丹红注射液与5种溶媒配伍后,不同直径的不溶性微粒均有所增加;与0．9％NS、转化糖、RS配伍后不溶性微粒数增加明显;与5％GS、10％GS配伍后,不溶性微粒数增加较少。结论：应加强中药注射液不溶性微粒的监测,注射丹红注射液时,应缓慢并密切观察患者病情的变化。     

Determination of drug release in vitro of atractylenolide Ⅰ liposome by RP-HPLC

Objective To establish a RP-HPLC method for the determination of drug release in vitro of atractylenolide Ⅰ liposomes. Methods The release behavior of the drug from liposomes was studied by the third method for dissolution. ZORBAX C18 column (4.6 mm × 250 mm, 5 μm) was used with a mobile phase of Methanol-Acetonitrile-0.2% from liposomes in vitro fitted the log-normal distribution equation and had a property of sustained release. Conclusion The method is simple, fast and selective. It is suitable for the determination of release profile in vitro of atractylenolide Ⅰ liposomes.