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991.
Yuki Tahata Ryotaro Sakamori Kazuki Maesaka Akira Doi Ryoko Yamada Takahiro Kodama Hayato Hikita Masanori Miyazaki Yasutoshi Nozaki Akira Kaneko Masahide Oshita Satoshi Tanaka Kazuho Imanaka Naoki Hiramatsu Naoki Morishita Kazuyoshi Ohkawa Takayuki Yakushijin Mitsuru Sakakibara Sadaharu Iio Yoshinori Doi Tomohide Tatsumi Tetsuo Takehara 《Hepatology research》2023,53(4):301-311
992.
Keisuke Watanabe Nobuyuki Horita Yu Hara Nobuaki Kobayashi Takeshi Kaneko 《The clinical respiratory journal》2023,17(4):303-310
Background
The clinical features of asthma with connective tissue diseases (CTDs) are not well-known. This study therefore aimed to investigate the clinical characteristics of asthma with CTDs.Methods
We retrospectively examined the records of adults (≥18 years old) with asthma followed up between January 2010 and December 2019. We then compared the clinical features of asthma with and without CTDs.Results
Among 568 subjects with asthma, 42 subjects (7.4%) had CTDs. The most frequent concomitant CTD was rheumatoid arthritis (n = 23, 54.8%), followed by systemic lupus erythematosus (n = 6, 14.3%). The proportion of women (with vs. without CTDs, 85.7% vs. 56.5%, p < 0.001) and Global Initiative for Asthma step were higher (Step 4 or 5, with vs. without CTDs, 81.0% vs. 62.0%, p = 0.01) in asthma with CTDs, whereas frequency of allergic rhinitis was higher in asthma without CTDs (with vs. without CTDs, 7.1% vs. 26.1%, p = 0.005). Eosinophil ratio (with vs. without CTDs, 2.1% vs. 3.5%, p = 0.009) and total immunoglobulin E level (with vs. without CTDs, 43 IU/mL vs. 237 IU/mL, p = 0.002) were lower in asthma with CTDs. In terms of lung function, percentage predicted forced vital capacity (with vs. without CTDs, 86.7% vs. 99.7%, p = 0.008) and percentage predicted forced expiratory volume in 1 s (%FEV1) (with vs. without CTDs, 77.2% vs. 88.4%, p = 0.02) were all lower in asthma with CTDs. With multivariable analysis, CTDs (odds ratio [OR] 2.8, 95%CI 1.3–6.0; p = 0.008), chronic obstructive pulmonary disease (OR 3.8, 95%CI 2.1–6.7; p < 0.001) and asthma onset at <20 years old (OR 1.8, 95%CI 1.1–3.2; p = 0.03) were associated with low FEV1 (defined as %FEV1 < 80%) in asthma.Conclusions
Asthma with CTDs was related to lower lung function and low-T2 inflammation asthma. 相似文献993.
Tamai Hiroya Nishina Naoshi Kikuchi Jun Izumi Keisuke Otomo Kotaro Yoshimoto Keiko Yamaoka Kunihiro Takeuchi Tsutomu Kaneko Yuko 《Clinical rheumatology》2023,42(3):721-730
Clinical Rheumatology - /objectives Several biological disease-modifying anti-rheumatic drugs (bDMARDs) have been widely used for the management of rheumatoid arthritis (RA). These drugs target... 相似文献
994.
Kazuo Kaneko Toshihiko Taguchi Hiroshi Yonemura Hiroyasu Ueno Zhenglin Li Shinya Kawai 《Clinical neurophysiology》2003,114(4):596-599
OBJECTIVE: To investigate changes in cortical motor neuron excitability after peripheral nerve injury, evoked spinal cord potentials (ESCPs) following hemispheric transcranial magnetic stimulation (TMS) were recorded in awake patients with unilateral brachial plexus injury. METHODS: ESCPs following hemispheric TMS were recorded in 6 patients with unilateral complete type brachial plexus injury. Studies were performed within 6 months from the time of injury. ESCPs were recorded from posterior epidural space using catheter electrodes. Hemispheric TMS was applied on the motor cortex using a figure-of-8 coil. The threshold of ESCPs following hemispheric TMS was measured. The number, latency, and amplitude of ESCPs following high stimulus hemispheric TMS were measured and compared. RESULTS: No significant change was observed in the threshold of ESCPs following TMS contra-lateral to the injured upper limb compared to that following TMS contra-lateral to the intact upper limb. Several ESCP components were recorded following high stimulus hemispheric TMS. No significant changes were observed in comparison with number, latency and amplitude of ESCPs following high stimulus TMS contra-lateral to the injured upper limb and those following TMS contra-lateral to the intact upper limb. CONCLUSIONS: From a study of ESCPs following single TMS, no evidence was obtained that cortical motor neuron excitability changes in patients with traumatic unilateral brachial plexus injury at relatively early stages. We investigated the changes of cortical motor neuron excitability in patients with brachial plexus injury from the ESCPs following TMS. In single TMS, our data gave no evidence for cortical excitability changes at relatively early stages. 相似文献
995.
Associations between side effects of nemonapride and plasma concentrations of the drug and prolactin
Kondo T Ishida M Tokinaga N Mihara K Yasui-Furukori N Ono S Kaneko S 《Progress in neuro-psychopharmacology & biological psychiatry》2002,26(2):287-291
Associations between neuroleptic side effects and plasma concentrations of the drug and prolactin were investigated in 33 acutely exacerbated schizophrenic patients (16 males and 17 females) treated with a fixed dose of nemonapride (18 mg/day), a new substituted benzamide, for 3 weeks. The most frequently observed side effects during nemonapride treatment were extrapyramidal symptoms such as akathisia (69.7%), dystonia (48.5%), hypokinesia (45.5%), tremor (39.4%) and increased salivation (36.4%). There were positive correlations between prolactin response and extrapyramidal side effects (EPS) scores after 1 week (Spearman rank correlation rs=.651, P<.01), 2 weeks (rs=.567, P<.05) and 3 weeks (rs=.670, P<.01) in male patients although no significant correlations were found in female or total patients. No significant correlations were found between plasma concentrations of the drug and total or any subscale side effects scores. The present study thus suggests that the spectrum of nemonapride-induced side effects is characterized by predominant extrapyramidal symptoms, and that prolactin response as an index of dopamine blockade reflects severity of EPS at least in male patients treated with nemonapride. 相似文献
996.
Serikawa T Abe T Minamikawa T Itsukaichi M Yamada K Saito T Kaneko T Wada M Takakuwa K Tanaka K 《The journal of obstetrics and gynaecology research》2011,37(8):1141-1144
A 35-year-old Japanese woman in the 24th week of gestation with bilateral breast enlargement was referred to hospital. She was diagnosed with Burkitt's lymphoma and admitted for detailed evaluation and treatment. Early delivery and subsequent chemotherapy was chosen after considering the gestational week, her general condition and the wishes of the patient and her husband. She gave birth to a male infant by cesarean section in the 25(th) week of gestation. It had been planned to begin high-dose chemotherapy, such as CODOX-M/IVAC, on day 7 of the puerperium; however, her general condition worsened and chemotherapy was therefore begun on day 2 after the birth. Eight hours after chemotherapy (cyclophosphamide, vincristine and doxorubicin), she developed cardiac arrest due to tumor lysis syndrome. Despite medical treatment, her bleeding tendency did not improve and she died of respiratory failure with alveolar bleeding five days after chemotherapy. 相似文献
997.
Tsunemi Y Nishibu A Saeki H Oyama N Nakamura K Kishimoto M Mitsui H Tada Y Torii H Komine M Asahina A Kaneko F Tamaki K 《Dermatology (Basel, Switzerland)》2003,207(4):371-374
BACKGROUND: Psoriasis features an increased level and activity of tumor necrosis factor alpha (TNF-alpha). The TNF-alpha gene has single nucleotide polymorphisms (SNPs) at positions -308 (-308G>A) and -238 (-238G>A) in the promoter region, and the -238G>A SNP has been reported to be associated with psoriasis vulgaris (PV) and psoriatic arthritis in Caucasians. OBJECTIVE: To examine whether these SNPs are associated with susceptibility to PV in Japanese patients, we investigated the genotype and allele frequencies at each SNP in Japanese PV patients and in controls. METHODS: We examined 163 PV patients and 96 healthy individuals. Genotyping was performed using the polymerase chain reaction-restriction fragment length polymorphism method. RESULTS: No significant association between the genotypes or alleles of these SNPs and susceptibility to PV was observed. CONCLUSION: These SNPs themselves are not associated with susceptibility to PV in the Japanese. 相似文献
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