立体定向分次放疗联合全脑放射治疗脑转移瘤疗效分析

Objective To evaluate efficiency of brain metastases tumor using X-knife under farctionational stereotactie radiotherapy (FSRT) combine with whole brain radiotherapy (WBRT). Methods Retrospective comparing 51 patients treated by FSRT plus WBRT (FSRT + WBRT group) with 35 patients treated by WBRT alone (WBRT group) on the effecting rate and survival rate. Results The completeness response rate was 49 % and 26 % (P < 0.05) in FSRT + WBRT and WBRT groups, respectively. The effecting rate was 80 % and 71 % (P 0.05) in FSRT + WBRT and WBRT groups, respectively. The middle survival time was (11.0 ± 1.5) months and (6.5 ± 0.5) months (P < 0.05) in FSRT + WBRT and WBRT groups, respeetivley. The 0.5-, 1.0- and 1.5-years survival rate was 63 % and 41 % (P 0.05), 51 % and 23 % (P 0.05) and 24 % and 9 % (P < 0.05) in FSRT + WBRT and WBRT groups, respectively. Conclusions The method with FSRT plus WBRT in the treatment of brain metastases tumor is safe and relieved focal symptom of patients quickly with lesser injury on normal tissue and the survival time be prolonged, it has better therapeutic effects than WBRT alone for treating brain metastases tumor.     

同期放化疗治疗局部中晚期鼻咽癌近期疗效观察

目的观察同期放化疗治疗局部中晚期鼻咽癌的疗效。方法69例Ⅲ-Ⅳa期局部中晚期鼻咽癌患者随机分组,34例入选单纯放疗组（对照组）,35例入选化疗加放疗治疗组（综合组）。于放疗始用化疗方案：PF方案化疗DDP 25mg/m^2,d1-3,ivgtt,CF 100 mg,d1-5,ivgtt,5-Fu 500 mg/m^2,d1-5,ivgtt,CF用后2 h静滴,3-4周重复,化疗2-3周期。放射治疗用6 MV-X线照射,以面颈联合野或耳前野为主野,面颈联合野照射DT 36Gy-40Gy/18F-20F后避开脊髓改双耳前野照射,或加鼻前野,颅底受侵者加颅底野,颈部为切线野和垂直野照射,鼻咽肿瘤区总剂量DT68-76Gy/34F-38F/7-8周,颈部淋巴结引流区剂量DT50Gy-60Gy/25F-30F/5-6周,有残存者追加剂量DT10Gy/5F/1周。结果两组结果显示在短期内原发灶肿瘤消退综合组好于单纯放疗组（P〈0.05）,远处转移率、3年生存率两组差异无统计学意义（P〉0.05）。结论放疗联合PF方案同步化疗可提高完全缓解率,降低局部复发率,未能观察到两组远处转移率、生存率方面的差异,可能与本组化疗周期较少有关。