Monitoring of intracerebellarly-administered natural killer cells with fluorine-19 MRI

Journal of Neuro-Oncology - Medulloblastoma (MB) is the most common malignant brain tumor in children. Recent studies have shown the ability of natural killer (NK) cells to lyse MB cell lines in...     

Multiple rhinosporidiosis

Rhinosporidiosis is due to an infection by the fungus Rhinosporidium seeberi, which affects predominantly the mucous membrane of the nose and nasopharynx but occasionallythe lips, palate, uvula, maxillary antrum, conjunctiva, lacrimal sac, epiglottis, larynx, trachea, bronchus, ear, scalp, skin, penis, vulva and vagina. The infection is usually limited to the surface epithelium but sometimes it becomes widely disseminated and the infection may then be found in any part of the body. The infection is chronic and is characterised by formation of papillomatous and polypoidal lesions (Satyanarayana, 1966). The case reported is one of chronic Rhinosporidiosis being followed up for the last 8 years, having multiple cutaneous, mucocutaneous and mucous membrane lesions.     

Photopolymerization of methyl methacrylate using quinoline-chlorine charge transfer complex as the photoinitiator

Photopolymerization of MMA was carried out at 40°C in bulk and in diluted systems using quinoline-chlorine (Q-Cl₂) C.T. complex as the photoinitiator. Bulk polymerization followed normal free radical kinetics (initiator exponent = 0,5) for [Q-Cl₂] <0,0015 mol.1^?1. In diluted systems, variable monomer exponents were observed, ranging from slightly above 1 to 2,7, depending on the nature of the solvent (benzene, carbon tetrachloride, chloroform, chlorobenzene, acetone, dioxane, THF and DMF). Initiator exponent was ≤0,5 in diluted systems and it even became practically equal to zero depending on the nature of solvent and the level of dilution. The kinetic non-ideality in diluted systems was explained on the basis of solvent-retardation and initiator-termination via degradative chain transfer involving solvent-modified initiating complexes and chain radicals. The actual initiating complex appeared to be the (Q-Cl₂)-monomer complex formed instantaneously in situ on addition of Q-Cl₂ complex to the monomer.     

A novel surgical technique for a rat subcutaneous implantation of a tissue engineered scaffold

Objectives

Subcutaneous implantations in small animal models are currently required for preclinical studies of acellular tissue to evaluate biocompatibility, including host recellularization and immunogenic reactivity.

Role of chemoradiotherapy in advanced carcinoma cervix

Carcinoma cervix is the commonest female malignancy in India. In advanced stages radiotherapy was the only treatment options available. Recently there is interest in chemotherapy but the combination, dosage and timing are not well standardised. With this background a trial was undertaken to evaluate the role of chemotherapy along with radiotherapy in advanced carcinoma cervix. One hundred and sixty patients of stages II B-IV A carcinoma cervix were randomised into two arms. Patients of radiotherapy alone arm were treated by external radiotherapy of 5000 cGy in conventional fractionation followed by brachytherapy. The second group received the same schedule of radiotherapy plus chemotherapy with injection cisplatin 30 mg/m2 once weekly for 5 weeks during the course of external radiotherapy. Patients were well matched in both the arms. Compliance rate is similar. The complete response rate was 83% with chemoradiotherapy arm while it was 73% with radiotherapy (p-value > 0.1). Neutropenia was the major dose limiting toxicity, the incidence and severity being more in chemoradiotherapy arm (grade 3 neutropenia 12% versus 0%). Radiation proctitis was the commonest late effect observed. In the median follow-up of 54 months, there is an increased overall survival (56% versus 47%); p-value > 0.1) and disease-free survival (51% versus 37%; p-value > 0.05) in the chemoradiotherapy arm.     

Orbital rhinosporidiosis

Rhinospordiosis, a chronic granulomatous disease of the mucocutaneous tissue, is endemic in India and other parts of South East Asia. It commonly affects the upper respiratory tract, but involvement of other sites has also been reported. A 27-year-old male patient reported with features simulating severe obital cellulitis underwent emergency managemt for his systemic problems. Subsequent CT scan and histopathological examination confirmed the diagnosis of rhinoporidiois. Definitive surgical treatment was done to remove the suspected papillomatous mass which led to marked improvement of the patient.     

Effect of Chloride Ions Concentrations to Breakdown the Passive Film on Rebar Surface Exposed to L-Arginine Containing Pore Solution

In the present study, 0.115 M L-arginine (LA) has been used as an eco-friendly inhibitor in simulated concrete pore solutions (SP-0) in order to form passive films on a steel rebar–solution interface until 144 h. Hence, 0.51 (SP-1) and 0.85 M NaCl (SP-2) were added in LA containing SP-0 solution to breakdown the passive film and to initiate corrosion reactions. The electrochemical results show that the charge transfer resistance (R_ct) of steel rebar exposed to SP-1 and SP-2 solutions increased with respect to immersion periods. The sample exposed to the SP-2 solution initiated the corrosion reaction at the steel rebar–solution interface after 24 h of NaCl addition and formed pits; on the other hand, the sample without NaCl added, i.e., SP-0, showed agglomeration and dense morphology of corrosion products.