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101.
Udayraj Premdas Nakade Satish Kumar Garg Abhishek Sharma Soumen Choudhury Rajkumar Singh Yadav Kuldeep Gupta Naresh Sood 《Indian journal of pharmacology》2015,47(1):22-26
Objectives:This study was undertaken to elucidate the adverse effect of lead on female reproductive system following in vivo exposure in rats.Results:Marked and a significant decrease in per cent body weight gain was observed in rats of Group IV and III, respectively, compared to that in the control group. Relative uterine weights were found to decrease by 27% in Group III and IV compared to control and low dose lead treated (30 ppm) rats. Lead levels were found to increase in a linear manner in blood along with a marked increase in bone levels in 100 ppm exposure group while there was a decrease in both the blood and bones levels at 300 ppm exposure. Compared to plasma progesterone levels in rats of the control group, a nonsignificant (12.46–21.13%) reduction in plasma progesterone were observed in different lead-treated groups. No apparent gross pathological lesions were observed in any of the vital organs, including uterus. However, histopathological examination of uteri of different groups revealed lead-induced dose-dependent inflammatory changes, which were characterized by thickening of the endometrium, narrowing of uterine lumen, damage to endometrial glands and vacuolar degeneration in endometrial epithelial cells.Conclusion:Findings of this study suggest lead-induced pathophysiological alterations in myometrium, which in turn may affect the reproductive efficiency of animals.KEY WORDS: Blood, bones, histopathology, inflammation, lead, uterus 相似文献
102.
103.
Sudipta Chakraborty Soumen Das Rubel Chakravarty Haladhar Dev Sarma Rakhee Vatsa Jaya Shukla Bhagwant Rai Mittal Ashutosh Dash 《Journal of labelled compounds & radiopharmaceuticals》2019,62(12):823-834
Radiolabeled Arg‐Gly‐Asp (RGD) peptide derivatives have immense potential for non‐invasive monitoring of malignancies overexpressing integrin αvβ3 receptors. Easy availability of suitable radiotracers would augment the utility of this class of molecular imaging agents. Towards this, the present article describes the development of an improved lyophilized kit for the routine clinical formulation of [99mTc]Tc complex of HYNIC‐conjugated dimeric cyclic RGD peptide derivative E‐[c(RGDfK)]2 (E = glutamic acid, f = phenyl alanine, K = lysine) without using Sn2+ and systematic evaluation of its efficacy. Five batches of the kits were prepared, and [99mTc]Tc‐HYNIC‐E[c(RGDfK)]2 radiotracer was synthesized with high radiochemical purity (98.6 ± 0.5%) and specific activity (124.8 GBq/μmol) using the kits. Biodistribution studies in C57BL/6 mice bearing melanoma tumor exhibited significant accumulation of the radiotracer in tumor (5.32 ± 0.56 %ID/g at 60 min p.i.), and this uptake was also found to be receptor‐specific by blocking studies. Preliminary human clinical investigations carried out in 10 breast cancer patients revealed high radiotracer uptake in the tumor along with good tumor‐to‐background contrast. The developed kit formulation showed an exceptionally high shelf‐life of at least 18 months. These results demonstrated promising attributes of the developed kit formulation and warrant more extensive clinical investigations. 相似文献
104.
105.
Soumen Khatua MD Girish Dhall MD Sharon O'Neil PhD Rima Jubran MD Judith G. Villablanca MD Araz Marachelian MD Arti Nastia MD Robert Lavey MD Arthur J. Olch PhD Ignacio Gonzalez MD Floyd Gilles MD Marvin Nelson MD Ashok Panigrahy MD Gordon McComb MD Mark Krieger MD Jing Fan MS Richard Sposto PhD Jonathan L. Finlay MB ChB 《Pediatric blood & cancer》2010,55(1):42-46
106.
R. Keerthi Abhishek Dutta Shruthi Agarwal Vikram Kani Abhishek Khatua 《Journal of maxillofacial and oral surgery》2018,17(1):59-63
The high rate of mortality associated with cancer is due to its inherent nature to metastasize. Perineural invasion (PNI) is a relatively rare mode of metastasis, and a distinct pathologic entity that can be observed in the absence of lymphatic or vascular invasion which is still shrouded by mystery. PNI is a marker of poor prognosis. Despite increasing recognition of this metastatic process, there has been little progress in the understanding of mechanisms behind PNI. The purpose of this article is to make surgeons aware of caudad to cephalad metastasis of oral cancer along trigeminal nerve. 相似文献
107.
108.
Murray SE Polesso F Rowe AM Basak S Koguchi Y Toren KG Hoffmann A Parker DC 《The Journal of clinical investigation》2011,121(12):4775-4786
NF-κB–inducing kinase (NIK) is an essential upstream kinase in noncanonical NF-κB signaling. NIK-dependent NF-κB activation downstream of several TNF receptor family members mediates lymphoid organ development and B cell homeostasis. Peripheral T cell populations are normal in the absence of NIK, but the role of NIK during in vivo T cell responses to antigen has been obscured by other developmental defects in NIK-deficient mice. Here, we have identified a T cell–intrinsic requirement for NIK in graft-versus-host disease (GVHD), wherein NIK-deficient mouse T cells transferred into MHC class II mismatched recipients failed to cause GVHD. Although NIK was not necessary for antigen receptor signaling, it was absolutely required for costimulation through the TNF receptor family member OX40 (also known as CD134). When we conditionally overexpressed NIK in T cells, mice suffered rapid and fatal autoimmunity characterized by hyperactive effector T cells and poorly suppressive Foxp3(+) Tregs. Together, these data illuminate a critical T cell–intrinsic role for NIK during immune responses and suggest that its tight regulation is critical for avoiding autoimmunity. 相似文献
109.
S Das S Singh JM Dowding S Oommen A Kumar TX Sayle S Saraf CR Patra NE Vlahakis DC Sayle WT Self S Seal 《Biomaterials》2012,33(31):7746-7755
Angiogenesis is the formation of new blood vessels from existing blood vessels and is critical for many physiological and pathophysiological processes. In this study we have shown the unique property of cerium oxide nanoparticles (CNPs) to induce angiogenesis, observed using both in?vitro and in?vivo model systems. In particular, CNPs trigger angiogenesis by modulating the intracellular oxygen environment and stabilizing hypoxia inducing factor 1α endogenously. Furthermore, correlations between angiogenesis induction and CNPs physicochemical properties including: surface Ce(3+)/Ce(4+) ratio, surface charge, size, and shape were also explored. High surface area and increased Ce(3+)/Ce(4+) ratio make CNPs more catalytically active towards regulating intracellular oxygen, which in turn led to more robust induction of angiogenesis. Atomistic simulation was also used, in partnership with in?vitro and in?vivo experimentation, to reveal that the surface reactivity of CNPs and facile oxygen transport promotes pro-angiogenesis. 相似文献
110.
Sarcar B Kahali S Prabhu AH Shumway SD Xu Y Demuth T Chinnaiyan P 《Molecular cancer therapeutics》2011,10(12):2405-2414
The purpose of this study was to determine the capacity of MK-1775, a potent Wee-1 inhibitor, to abrogate the radiation-induced G(2) checkpoint arrest and modulate radiosensitivity in glioblastoma cell models and normal human astrocytes. The radiation-induced checkpoint response of established glioblastoma cell lines, glioblastoma neural stem (GNS) cells, and astrocytes were determined in vitro by flow cytometry and in vivo by mitosis-specific staining using immunohistochemistry. Mechanisms underlying MK-1775 radiosensitization were determined by mitotic catastrophe and γH2AX expression. Radiosensitivity was determined in vitro by the clonogenic assay and in vivo by tumor growth delay. MK-1775 abrogated the radiation-induced G(2) checkpoint and enhanced radiosensitivity in established glioblastoma cell lines in vitro and in vivo, without modulating radiation response in normal human astrocytes. MK-1775 appeared to attenuate the early-phase of the G(2) checkpoint arrest in GNS cell lines, although the arrest was not sustained and did not lead to increased radiosensitivity. These results show that MK-1775 can selectively enhance radiosensitivity in established glioblastoma cell lines. Further work is required to determine the role Wee-1 plays in checkpoint activation of GNS cells. 相似文献