全文获取类型
收费全文 | 1282598篇 |
免费 | 95017篇 |
国内免费 | 2014篇 |
专业分类
耳鼻咽喉 | 18286篇 |
儿科学 | 42506篇 |
妇产科学 | 38076篇 |
基础医学 | 188090篇 |
口腔科学 | 35635篇 |
临床医学 | 108865篇 |
内科学 | 252410篇 |
皮肤病学 | 26672篇 |
神经病学 | 99923篇 |
特种医学 | 50490篇 |
外国民族医学 | 383篇 |
外科学 | 198695篇 |
综合类 | 26582篇 |
现状与发展 | 1篇 |
一般理论 | 306篇 |
预防医学 | 93316篇 |
眼科学 | 29106篇 |
药学 | 98386篇 |
1篇 | |
中国医学 | 2511篇 |
肿瘤学 | 69389篇 |
出版年
2018年 | 12022篇 |
2016年 | 10245篇 |
2015年 | 11824篇 |
2014年 | 16273篇 |
2013年 | 24726篇 |
2012年 | 34052篇 |
2011年 | 36436篇 |
2010年 | 21505篇 |
2009年 | 20316篇 |
2008年 | 35460篇 |
2007年 | 38404篇 |
2006年 | 38975篇 |
2005年 | 38247篇 |
2004年 | 36814篇 |
2003年 | 35813篇 |
2002年 | 35317篇 |
2001年 | 58434篇 |
2000年 | 59967篇 |
1999年 | 51027篇 |
1998年 | 14374篇 |
1997年 | 12925篇 |
1996年 | 13179篇 |
1995年 | 12365篇 |
1994年 | 11786篇 |
1993年 | 10894篇 |
1992年 | 41184篇 |
1991年 | 40574篇 |
1990年 | 40083篇 |
1989年 | 38880篇 |
1988年 | 36261篇 |
1987年 | 35494篇 |
1986年 | 33874篇 |
1985年 | 32285篇 |
1984年 | 24036篇 |
1983年 | 20915篇 |
1982年 | 12395篇 |
1981年 | 10952篇 |
1979年 | 22707篇 |
1978年 | 15918篇 |
1977年 | 13759篇 |
1976年 | 12997篇 |
1975年 | 14228篇 |
1974年 | 16735篇 |
1973年 | 16141篇 |
1972年 | 15363篇 |
1971年 | 14290篇 |
1970年 | 13244篇 |
1969年 | 12763篇 |
1968年 | 12020篇 |
1967年 | 10501篇 |
排序方式: 共有10000条查询结果,搜索用时 250 毫秒
991.
Eric Racine Marie-Josée Dion Christine A. C. Wijman Judy Illes Maarten G. Lansberg 《Neurocritical care》2009,11(3):345-352
Background
Advances in intensive care medicine have increased survival rates of patients with critical neurological conditions. The focus of prognostication for such patients is therefore shifting from predicting chances of survival to meaningful neurological recovery. This study assessed the variability in long-term outcome predictions among physicians and aimed to identify factors that may account for this variability. 相似文献992.
FDA’S Perspectives on Cardiovascular Devices 总被引:1,自引:0,他引:1
Eric A. Chen Sonna M. Patel-Raman Kathryn O’Callaghan Matthew G. Hillebrenner 《Journal of cardiovascular translational research》2009,2(2):143-146
The Food and Drug Administration (FDA) decision process for approving or clearing medical devices is often determined by a
review of robust clinical data and extensive preclinical testing of the device. The mission statement for the Center for Devices
and Radiological Health (CDRH) is to review the information provided by manufacturers so that it can promote and protect the
health of the public by ensuring the safety and effectiveness of medical devices deemed appropriate for human use (Food, Drug
& Cosmetic Act, §903(b)(1, 2(C)), December 31, 2004; accessed December 17, 2008 ). For high-risk devices, such as ventricular assist devices (VADs), mechanical heart valves, stents, cardiac resynchronization
therapy (CRT) devices, pacemakers, and defibrillators, the determination is based on FDA’s review of extensive preclinical
bench and animal testing followed by use of the device in a clinical trial in humans. These clinical trials allow the manufacturer
to evaluate a device in the intended use population. FDA reviews the data from the clinical trial to determine if the device
performed as predicted and the clinical benefits outweigh the risks. This article reviews the regulatory framework for different
marketing applications related to cardiovascular devices and describes the process of obtaining approval to study a cardiovascular
device in a U.S. clinical trial. 相似文献
993.
994.
L. TIMMER-DE MIK M.D. D.M. BROEKHUIJSEN-VAN HENTEN M.D. † J.M. OLDHOFF M.D. PH.D. D.B. DE GEER M.D. ‡ V. SIGURDSSON M.D. PH.D. S.G.M.A. PASMANS M.D. PH.D. 《Pediatric dermatology》2009,26(3):358-360
Abstract: In Sweet's syndrome, the essential features are the characteristic morphology of the lesions, their histologic appearance, the dramatic response to corticosteroids and the absence of scarring. We report an 8-month-old infant in whom Sweet's syndrome was diagnosed and who developed acquired cutis laxa in the skin lesions. 相似文献
995.
996.
Jerry G. Blaivas 《International urogynecology journal》2009,20(12):1401-1402
997.
Onur Hapa Hüsamettin ?ak?c? Kaan Gidero?lu Kutay ?zturan Aysel Kükner Güler Bu?dayc? 《Archives of orthopaedic and trauma surgery》2009,129(12):1721-1726
Introduction
Ethanol has a suppressive effect on inflammation and the immune system, but the effect of ethanol on tendon healing in vivo has not been studied. The purpose of this study was to investigate the histological and biomechanical effects of ethanol intake on tendon healing in a rat tendon injury model. 相似文献998.
999.
Objectives
For individuals not on antiretroviral therapy, the risk of heterosexual transmission of HIV appears negligible when blood plasma (BP) viral loads are <1500 HIV‐1 RNA copies/mL. It is not clear whether this observation can be extrapolated to individuals on highly active antiretroviral therapy (HAART). Because of differential tissue penetration, antiretroviral drug concentrations may be sufficient to maintain an undetectable viral load in the BP yet not achieve adequate levels to suppress HIV in the genital tract. Therefore, we wanted to correlate HIV viral loads and drug concentrations in semen plasma (SP) and BP.Methods
Thirty‐three men were included. All were on combination antiretroviral therapy with an undetectable BP viral load for at least 1 year. Blood and semen samples were collected within 2 h of each other and tested for HIV RNA by the NucliSens QT (bioMerieux, St Laurent, QC, Canada) method; drug concentrations were determined by liquid chromatography tandem mass spectrometry.Results
Two of the 33 patients (6.1%) with BP viral loads below detection had time‐matched HIV viral loads in SP ≥700 copies/mL. Both patients were on efavirenz, the SP concentrations of which were ≤10% of the levels in BP and well below the minimal therapeutic drug monitoring target concentration required to suppress HIV.Conclusions
Because, at least in part, of poor drug penetration into the genital tract, an undetectable HIV viral load in the BP does not guarantee an undetectable viral load in semen. In view of this, caution should be taken in concluding that patients on HAART with suppressed viraemia are sexually non‐infectious. 相似文献1000.