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41.
Guerrini G Costanzo A Bruni F Ciciani G Selleri S Gratteri P Costa B Martini C Lucacchini A 《Il Farmaco; edizione pratica》1999,54(6):375-389
A new series of 2- and/or 3-substituted pyrazolo [5,1-c][benzotriazine 5-oxides and their 8-chloro derivatives were synthesized, and their benzodiazepine receptor (BZR) affinities were evaluated in vitro in comparison to lead compound 3-ethoxycarbonyl-8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide (29) [1,2]. None of the new compounds showed significant affinity for BZR. On the basis of a pharmacophore/receptor model suggested for lead compound 29, some hypotheses to explain the inactivity of new derivatives are discussed. 相似文献
42.
Maltoni M Sansoni E Derni S Milandri C Martini F Nanni O Fabbri L Amadori D 《Oncology reports》1996,3(1):205-208
Oral mucositis is a frequent complication of specific antineoplastic treatments. Mouth lesions have a great impact on the quality of life of cancer patients. Current topical and systemic therapies have not yet achieved completely satisfactory results. We studied the effect of topical use of prostaglandin E2 (PGE2) 2.25 mg/day on oral mucositis of 15 chemo- or radio-treated cancer patients. Absolute mean VAS value on mouth pain decreased from 71.2 at TO, to 34.1 at T3 (p<0.001) and to 14.1 at T6 (p<0.001). Objective evaluation according to Miller scale showed significant improvement at day 3 and 6, as well. We suggest that PGE2 could be a useful additional therapeutic agent to palliate oral symptoms. 相似文献
43.
Summary A study of nine cases of post-traumatic avascular necrosis of the head of the humerus is presented with a review of 60 cases previously published. Onset of symptoms begins between one and two years after fracture. Pain and stiffness are the principal features. The clinical picture eventually stabilises with decreasing pain and variable loss of movement. The chief radiological changes are sclerosis and a snow-cap appearance of the head or a characteristic spanner-shaped deformity. The possible causative factors are listed and the importance of associated vascular damage emphasised. Conservative treatment is usually adequate but prosthetic replacement of the head may be indicated.
Résumé Les auteurs analysent 60 cas de nécrose post-traumatique de la tête humérale publiés dans la littérature, auxquels ils ajoutent neuf cas personnels.Ils soulignent le rôle des facteurs combinés dans la pathogénie parmi lesquels le facteur vasculaire est le plus important. Après 1 à 2 ans de latence, les manifestations cliniques apparaissent et vont évoluer lentement vers une certaine stabilisation, en particulier des phénomènes douloureux, souvent intenses au début, mais au prix d'une raideur résiduelle quasi constante. La radiologie reconnaît deux types principaux d'image:condensation en calotte de neige;déformation en clé anglaise de la tête humérale;la glène restant très longtemps indemne.Le traitement, le plus souvent médical, devrait peut-être ressortir de la chirurgie par prothèse type Neer, qui pourrait dans les types les plus graves, être placée préventivement.相似文献
44.
Stab wounds of the hand should not be dismissed lightly as trifles. It may well be that deep underlying structures are destroyed even if the injury is very small, hardly visible and thus seems to be negligible. As a matter of fact, such injuries are easily overlooked particularly by the patient himself and, possibly, also by an inexperienced nurse or examiner. The most serious consequences can arise from non-diagnosed complete and incomplete injuries of tendons and nerves. The authors emphasise the importance of paying close attention to complete or partial injuries of the extensor tendons and nerves. If at all possible, these should be looked after immediately. Particular emphasis is placed by the authors on complete or partial injuries in the region of the proximal interphalangeal joints, involving the risk of a typical "buttonhole" deformity. Among the typical sequels of a stab injury are lesions of the nerves of the fingers as well as of the flexor and extensor tendons, quite apart from the general danger of an infection. Whereas injuries of the extensor tendons do not place great demands on the skill of the surgeon, injuries of the tendons and nerves in the flexor region are the domain of the hand surgeon. 相似文献
45.
Soluble CD40 ligand plasma levels in lung cancer. 总被引:7,自引:0,他引:7
Mario Roselli Tommaso C Mineo Stefania Basili Francesca Martini Sabrina Mariotti Simona Aloe Girolamo Del Monte Vincenzo Ambrogi Antonella Spila Raffaele Palmirotta Roberta D'Alessandro Giovanni Davì Fiorella Guadagni Patrizia Ferroni 《Clinical cancer research》2004,10(2):610-614
PURPOSE: Tumor-induced platelet activation may cause the release of various cytokines, including CD40 ligand (CD40L). Activation of the CD40/CD40L pathway in human tumors may result in thrombin generation, which is known to be involved in angiogenesis. Thus, we investigated whether soluble (s)CD40L levels are increased in patients with lung cancer as a result of platelet and/or coagulation activation. EXPERIMENTAL DESIGN: Citrated plasma samples were obtained from 120 patients with different stages and histotypes of lung cancer and 60 age- and sex-matched control subjects. sCD40L, sP-selectin (marker of platelet activation), prothrombin fragment 1 + 2, and thrombin-antithrombin III complex levels (both markers of coagulative activation) were measured in all samples. RESULTS: Patients with lung cancer had median sCD40L levels higher than in control subjects (0.46 versus 0.13 ng/ml; P < 0.0001), although correlation with the stage of disease was not evident. Nonetheless, sCD40L levels were significantly higher in squamous cancer compared with adenocarcinoma (0.75 versus 0.27 ng/ml; P < 0.05). Moreover, median sCD40L levels were higher in stage IV compared with nonmetastatic squamous lung cancer (1.02 versus 0.61 ng/ml; P < 0.05). sCD40L levels significantly correlated with sP-selectin (P < 0.001), prothrombin fragment 1 + 2 (P < 0.001), or thrombin-antithrombin III complex (P < 0.05) in squamous lung cancer, but only sP-selectin (P = 0.011) was independently related to sCD40L. CONCLUSIONS: These findings indicate that elevated sCD40L levels can be preferentially found in patients with advanced squamous cancer and provide evidence that increased levels of this cytokine are associated to the occurrence of in vivo platelet activation. 相似文献
46.
A registry-based study of follow-up failures in the screening experience of cervical cancer patients
Amadori Gentilini Bucchi Innocenti Falcini Martini Fabbri Liverani Danesi Piantini Milandri Saragoni & Amadori 《International journal of gynecological cancer》1998,8(3):251-256
Amadori A, Gentilini P, Bucchi L, Innocenti MP, Falcini F, Martini F, Fabbri M, Liverani M, Danesi S, Piantini B, Milandri C, Saragoni L, Amadori D. A registry-based study of follow-up failures in the screening experience of cervical cancer patients. Int J Gynecol Cancer 1998; 8 : 251–256.
Although all components of cervical screening are at risk of error, most studies of the previous screening experience of cervical cancer patients addressed only the false negative cytology results. Other reports showed the importance of screening failures not attributable to the Pap smear. We studied the relative frequency of all types of error observed in the screening history of 115 cervical cancer cases (median age, 60; range, 23–89) registered with the population-based Romagna Cancer Registry in Forlì (northern Italy) between 1986 and 1993. For each case, a search was made for all cytology, colposcopy, biopsy, and treatment reports issued prior to diagnosis. Eighty-one (70.4%) patients had never had a Pap smear. Eight (7.0%) were diagnosed at their first test. Twenty-six patients (22.6%) had had at least one previous smear. Among these, 10 were screened during the five years prior to diagnosis: three patients had false negative cytology results, one patient did not comply with the recommendation for an early repeat smear, two patients with positive cytology results underwent colposcopy with considerable delay (7 and 9 months), one patient had a negative colposcopy (without biopsy), and three patients had biopsies histologically reported as negative. An overview of the registry-based studies of screening histories reported so far from Italy (total number of cases 262) demonstrated that patients with serious shortcomings in follow-up after smear test, colposcopy, biopsy, clinical assessment, and treatment accounted for a substantial proportion of screening failures. 相似文献
Although all components of cervical screening are at risk of error, most studies of the previous screening experience of cervical cancer patients addressed only the false negative cytology results. Other reports showed the importance of screening failures not attributable to the Pap smear. We studied the relative frequency of all types of error observed in the screening history of 115 cervical cancer cases (median age, 60; range, 23–89) registered with the population-based Romagna Cancer Registry in Forlì (northern Italy) between 1986 and 1993. For each case, a search was made for all cytology, colposcopy, biopsy, and treatment reports issued prior to diagnosis. Eighty-one (70.4%) patients had never had a Pap smear. Eight (7.0%) were diagnosed at their first test. Twenty-six patients (22.6%) had had at least one previous smear. Among these, 10 were screened during the five years prior to diagnosis: three patients had false negative cytology results, one patient did not comply with the recommendation for an early repeat smear, two patients with positive cytology results underwent colposcopy with considerable delay (7 and 9 months), one patient had a negative colposcopy (without biopsy), and three patients had biopsies histologically reported as negative. An overview of the registry-based studies of screening histories reported so far from Italy (total number of cases 262) demonstrated that patients with serious shortcomings in follow-up after smear test, colposcopy, biopsy, clinical assessment, and treatment accounted for a substantial proportion of screening failures. 相似文献
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50.
B. S. E. Peters E. Verly Jr D. M. L. Marchioni M. Fisberg L. A. Martini 《Journal of human nutrition and dietetics》2012,25(1):69-74
Background: Given the importance of both calcium and vitamin D for bone health and the high prevalence of vitamin D from around the world, the present study aimed to evaluate calcium and vitamin D intake in a group of healthy Brazilian adolescents and young adults and to examine the influence of breakfast and dairy products in the total intake of these nutrients. Methods: One hundred and sixty adolescents and young adults, aged 16–20 years old, from a public school, participated in the present study. Three‐day dietary records were used to assess calcium and vitamin D intakes. Serum 25(OH)D levels were measured using a radioimmunoassay kit. The results were expressed as the mean (SD). Results: Only 3.8% of the subjects met the daily adequate intake recommendation for calcium, and none for vitamin D [682.2 (132.2) mg day?1 and 124.0 (28.0) IU day?1, respectively]. 25(OH)D serum levels were insufficient in 51.5% and deficient in 9.7% of the individuals [72.5 (22.3) nmol L?1]. There was a significant positive correlation between dairy product intake with both calcium and vitamin D (r = 0.597 and r = 0.561, respectively; P = 0.000). Adolescents who ate breakfast had a significant higher mean calcium, vitamin D and dairy product intake than adolescents who did not report this meal. Conclusions: The majority of adolescents and young adults did not consume recommended intakes of calcium and vitamin D and also presented 25(OH)D insufficiency. The results indicate that a regular breakfast and the consumption of dairy products represent important strategies in improving calcium and vitamin D intake in the diet. 相似文献