性病患者100例心理状况分析

1临床资料2003-03/2004-12就诊性病患者100(男68,女32)例;年龄19～60岁;文化程度中学以下78例,大专以上22例;职业个体49例,有工作单位39例,无业12例;病种尖锐湿疣52例、非淋菌性尿道炎20例、淋病18例、梅毒3例、生殖器疱疹7例; 96例经0.5～6.0 mo的治疗康复,4例病情好转. 接诊过程从交谈及肢体语言发现,98%的患者就诊时对病史遮遮掩掩,甚至隐瞒,觉得羞耻,见不得人,愧对家人;68%的患者由于对性病的一知半解,存在有恐惧感、悲观、自责、压抑、焦虑的情绪表现;36%的患者担心家人、同事知道病情而引发一系列家庭、工作问题[1];43%的患者担心病情加重、扩散、传染家人、治疗后复发、未彻底治愈以及治疗费用太高等.     

The factors controlling stem cell recirculation. i. Migration of hemopoietic stem cells in adrenalectomized mice

The influence of bilateral adrenalectomy on hemopoietic stem cell (CFU) migration in mice has been studied. Formation of endogenous spleen colonies in lethally irradiated, leg-shielded mice was sharply increased by prior adrenalectomy, and this increase was not dependent on the volume of shielded bone marrow. Adrenalectomy was shown to increase endogenous spleen colony formation in sublethally irradiated mice as well. However, it had no affect on formation of spleen colonies in lethally irradiated mice injected with syngeneic bone marrow. The CFU content of murine bone marrow decreased acutely after removal of the adrenals, and this decrease was accompanied by a concomitant increase in the peripheral blood and splenic CFU. Thus, adrenalectomy appeared to have no affect on the splenic plating efficiency or proliferative rate of hemopoietic stem cells, but it did result in increased migration of stem cells from the bone marrow to the blood, and thence to the spleen. It is concluded that the adrenal steroids may be of physiologic importance in the regulation of ehmopoietic stem cell migration.     

Gu, a Variant of G

G^u, analogous to D^u and E^u, is a weak variant of G appearing in a haplotype lacking C, D, and E but having e^s.
In a preliminary survey, the red blood cells ot three of 186 Negro blood donors found negative when tested for C, D (incuding D^u), and E were shown to be G^u-positive when tested with anti-CD by the antiglobulin technic.
Fourteen additional examples from unrelated persons and five members of a family have been investigated in this study. All G^u-positive individuals tested are VS-positive, but V-negative, and all are Negro. Although G cells show greater antibody uptake when used to absorb anti-CD, G^u cells elute anti-G in substantially greater amounts than do G cells. Comparative studies demonstrate similarity of specificity but a difference of avidity, which could be due to the influence of e^s(VS) in cis position.
G^u-positive bloods have been shown to stimulate the production of anti-G in Rh-negative recipients. The test for G^u can be incorporated in the test for D^u by substituting anti-CD or anti-CDE for anti-D serum.     

Enlarged gastric folds in association with Campylobacter pylori gastritis

Enlarged gastric folds in pediatric patients are uncommon. Fifteen patients with upper gastrointestinal (GI) tract symptoms of chronic epigastric abdominal pain, vomiting, or hematemesis underwent radiologic upper GI barium studies and were found to have Campylobacter pylori gastritis at endoscopic biopsy. Seven patients (47%) with C pylori gastric disease had radiologic evidence of enlarged folds. There was no clinical or pathologic evidence of Ménétrier disease. Therefore, C pylori gastritis should be considered in the differential diagnosis of children with upper GI tract symptoms and radiologic evidence of enlarged folds.     

Anthelmintic activity of Securidaca longepedunculata (Family: Polygalaceae) root extract in mice,in vitro and in vivo

ObjectiveTo elucidate the pharmacological bases of oral administration of Securidaca longepedunculata (S. longepedunculata) root extract as an anthelmintic in folkloric medicine.MethodsAlbino mice were infected with infective third (L3) larval stage of Heligmosomoides polygyrus (H. polygyrus) by esophageal intubation. Following establishment of the adult worms in the intestine, the mice were treated with 0–2 000 mg/kg body weight (bw) of methanolic root extract of S. longepedunculata and 100 mg/kg bw of pyrantel embonate, the reference drug in vivo. Bioactivity and larvicidal effects of the extract were tested by exposing brine shrimps (Artemia salina) to 0.00–1.00 mg/mL and the L3 stage of Heligmosomoides contortus (H. contortus) and H. polygyrus to 0.00–2.50 mg/mL of the extract in vitro.ResultsThe percentage yield of the extract was 7.13% w/w dry matter. The brine shrimps toxicity bioassay resulted in an LC₅₀ of 74.18 μg/mL. The extract had a significant, dose–dependent larvicidal effect on the L3 stage of H. contortus and H. polygyrus with the terminal effect of 75% and 70% at the highest exposure concentrations, respectively. The extract however, did not affect the number of worm eggs per gram (epg) of fecal materials (P<0.05) and total worm burden (twb) of adult H. polygyrus in infected mice. Treatment with pyrantel embonate significant reduced both the fecal egg count and twb to 0 compared to the untreated control (P<0.05).ConclusionsThese results indicate that S. longepedunculata root extract contains potent bioactive compounds and has larvicidal effect on L3 stage of H. contortus and H. polygyrus, substantiating its use as anthelmintic in alternative medicine.