全文获取类型
收费全文 | 32384篇 |
免费 | 1613篇 |
国内免费 | 206篇 |
专业分类
耳鼻咽喉 | 260篇 |
儿科学 | 543篇 |
妇产科学 | 295篇 |
基础医学 | 4204篇 |
口腔科学 | 723篇 |
临床医学 | 2063篇 |
内科学 | 7882篇 |
皮肤病学 | 1424篇 |
神经病学 | 3010篇 |
特种医学 | 1280篇 |
外科学 | 5400篇 |
综合类 | 167篇 |
预防医学 | 855篇 |
眼科学 | 519篇 |
药学 | 2495篇 |
中国医学 | 78篇 |
肿瘤学 | 3005篇 |
出版年
2023年 | 154篇 |
2022年 | 177篇 |
2021年 | 628篇 |
2020年 | 334篇 |
2019年 | 482篇 |
2018年 | 653篇 |
2017年 | 515篇 |
2016年 | 658篇 |
2015年 | 684篇 |
2014年 | 871篇 |
2013年 | 1032篇 |
2012年 | 1700篇 |
2011年 | 1857篇 |
2010年 | 1015篇 |
2009年 | 856篇 |
2008年 | 1696篇 |
2007年 | 1875篇 |
2006年 | 1778篇 |
2005年 | 1871篇 |
2004年 | 1861篇 |
2003年 | 1859篇 |
2002年 | 1737篇 |
2001年 | 766篇 |
2000年 | 788篇 |
1999年 | 802篇 |
1998年 | 493篇 |
1997年 | 355篇 |
1996年 | 326篇 |
1995年 | 319篇 |
1994年 | 250篇 |
1993年 | 232篇 |
1992年 | 529篇 |
1991年 | 480篇 |
1990年 | 472篇 |
1989年 | 504篇 |
1988年 | 465篇 |
1987年 | 425篇 |
1986年 | 370篇 |
1985年 | 325篇 |
1984年 | 215篇 |
1983年 | 188篇 |
1982年 | 112篇 |
1981年 | 100篇 |
1980年 | 87篇 |
1979年 | 187篇 |
1978年 | 104篇 |
1977年 | 94篇 |
1975年 | 85篇 |
1973年 | 90篇 |
1972年 | 89篇 |
排序方式: 共有10000条查询结果,搜索用时 500 毫秒
51.
Seiichi Saito Shunichi Namiki Kenji Numahata Makoto Satoh Shigeto Ishidoya Akihiro Ito Haruo Nakagawa Yasuhiro Kaiho Takehiko Sanada Atsushi Yamada Yoichi Arai 《International journal of urology》2007,14(2):133-139
PURPOSE: To determine the effect of an interposition nerve graft on sexual function after radical prostatectomy. METHODS: This study includes 64 patients, without hormonal therapy, who underwent a radical prostatectomy and intraoperative electrophysiological confirmation of cavernous nerve preservation. Twelve patients underwent a unilateral interposition sural nerve graft (UNG) for the resected neurovascular bundle. Twenty-one and 31 patients underwent bilateral nerve-sparing (BNS) and unilateral nerve-sparing (UNS) surgery without a nerve graft, respectively. As the age of patients was significantly younger in the UNG group than in the other groups, age-matched analysis also was conducted. Sexual function, evaluated by a self-administered questionnaire using the University of California Los Angeles-Prostate Cancer Index, was compared statistically among the three groups. RESULTS: In the age-matched analysis, the postoperative sexual function (SXF) score of the UNG group showed an intermediate level of recovery between those of the BNS and UNS groups at 12 months and reached the same level as the score at 12 months of the BNS group at 18 months postoperatively. The difference in the SXF score between the UNG and UNS groups began to appear after 6 months postoperatively and increased steadily with time. However, the background factors, such as the baseline SXF score, the usage rate of phosphodiesterase 5 inhibitors, and the rate of comorbidities were different between the UNG and UNS groups. CONCLUSIONS: The difference of the SXF score between the UNG and UNS groups increased with time after 6 months postoperatively. However, it might be difficult at present to attribute a better recovery of the SXF score to the nerve graft because of the difference in the background factors between the groups. 相似文献
52.
Resetting of the arterial baroreflex increases orthostatic sympathetic activation and prevents postural hypotension in rabbits 总被引:1,自引:1,他引:0
Atsunori Kamiya Toru Kawada Kenta Yamamoto Daisaku Michikami Hideto Ariumi Kazunori Uemura Can Zheng Syuji Shimizu Takeshi Aiba Tadayoshi Miyamoto Masaru Sugimachi Kenji Sunagawa 《The Journal of physiology》2005,566(1):237-246
Since humans are under ceaseless orthostatic stress, the mechanism to maintain arterial pressure (AP) under orthostatic stress against gravitational fluid shift is of great importance. We hypothesized that (1) orthostatic stress resets the arterial baroreflex control of sympathetic nerve activity (SNA) to a higher SNA, and (2) resetting of the arterial baroreflex contributes to preventing postural hypotension. Renal SNA and AP were recorded in eight anaesthetized, vagotomized and aortic-denervated rabbits. Isolated intracarotid sinus pressure (CSP) was increased stepwise from 40 to 160 mmHg with increments of 20 mmHg (60 s for each CSP level) while the animal was placed supine and at 60 deg upright tilt. Upright tilt shifted the CSP–SNA relationship (the baroreflex neural arc) to a higher SNA, shifted the SNA–AP relationship (the baroreflex peripheral arc) to a lower AP, and consequently moved the operating point to marked high SNA while maintaining AP. A simulation study suggests that resetting in the neural arc would double the orthostatic activation of SNA and increase the operating AP in upright tilt by 10 mmHg, compared with the absence of resetting. In addition, upright tilt did not change the CSP–AP relationship (the baroreflex total arc). A simulation study suggests that although a downward shift of the peripheral arc could shift the total arc downward, resetting in the neural arc would compensate this fall and prevent the total arc from shifting downward to a lower AP. In conclusion, upright tilt increases SNA by resetting the baroreflex neural arc. This resetting may compensate for the reduced pressor responses to SNA in the peripheral cardiovascular system and contribute to preventing postural hypotension. 相似文献
53.
Mikiko Ueda Fumitaka Oike Yasuhiro Ogura Kenji Uryuhara Yasuhiro Fujimoto Mureo Kasahara Kohei Ogawa Koichi Kozaki Hironori Haga Koichi Tanaka 《Liver transplantation》2006,12(9):1326-1336
This report concerns the long-term outcome of living donor liver transplantation (LDLT) for pediatric patients at a single center. Between June 1990 and December 2003, a total of 600 LDLTs, including 568 primary transplantations and 32 retransplantations, were performed for pediatric patients, who were immunosuppressed with FK506 and low-dose corticosteroids. Patient survival at 1, 5, and 10 years were 84.6%, 82.4%, and 77.2%, respectively, and the corresponding findings for graft survivals were 84.1%, 80.9%, and 74.5%. Multivariate analysis demonstrated that fulminant hepatic failure (FHF), a graft vs. body weight (GBWR) ratio of <0.8, and ABO-incompatible transplants were independently associated with both patient and graft survival. The retransplantation rate was 6%, and 55 patients (9.7%) have been completely weaned off immunosuppressants. Long-term patient and graft survival after pediatric LDLT for a large cohort of children at our hospital were found to be as good as those for cadaveric liver transplantation, although this series includes 13% liver transplantations with ABO-incompatible donors, which are obviously inferior in patient and graft survival. To obtain better outcomes for patients with FHF and for patients with ABO-incompatible transplants, immunosuppressive therapy needs to be improved. 相似文献
54.
55.
Summary cDNA clones spanning the entire region of the peplomer (S) gene of feline infectious peritonitis virus (FIPV) type I strain KU-2 were obtained and their complete nucleotide sequences were determined. A long open reading frame (ORF) encoding 1464 amino acid residues was found in the gene, which was 12 residues longer than the ORF of the FIPV type II strain 79–1146. The sequences of FIPV type I and mainly FIPV type II were compared. The homologies at the N- (amino acid residues 1–693) and C- (residues 694–1464) terminal halves were 29.8 and 60.7%, respectively. This was much lower than that between FIPV type II and other antigenically related coronaviruses, such as transmissible gastroenteritis virus of swine and canine coronavirus. This supported the serological relatedness of the viruses and confirmed that the peplomer protein of FIPV type I has distinct structural features that differ from those of antigenically related viruses. 相似文献
56.
Symptomatic liver cyst: Special reference to surgical management 总被引:2,自引:0,他引:2
Kenji Kakizaki Hidemi Yamauchi Shin Teshima 《Journal of Hepato-Biliary-Pancreatic Surgery》1998,5(2):192-195
We conducted a retrospective study of 14 patients with symptomatic liver cysts to evaluate current therapeutic interventions
for this condition. Abdominal pain (n = 7) or abdominal mass (n = 5) were the most frequent presentations. Three patients also had renal cyst. Percutaneous aspiration with ethanol sclerotheraphy
was carried out in 4 patients and all cysts so treated diminished in size, with relief of the symptoms. One patient was treated
by aspiration only and re-retension occurred. Cystectomy was performed in 2 patients, unroofing in 5, and fenestration in
2 patients. All patients gained relief of symptoms, with no recurrence of symptoms. Computed tomography revealed that the
cysts were diminished or were no longer observable after all the treatments. Our experience indicates that unroofing, fenestration,
and cystectomy are safe and suitable procedures for treatment of the condition. Ethanol sclerotherapy may be a feasible alternative
to surgical intervention in selected patients.
Received for publication on July 23, 1997; accepted on Dec. 25, 1997 相似文献
57.
FR900403, a new antifungal antibiotic produced by a Kernia sp 总被引:3,自引:0,他引:3
T Iwamoto A Fujie Y Tsurumi K Nitta S Hashimoto M Okuhara 《The Journal of antibiotics》1990,43(9):1183-1185
58.
A Fujie T Iwamoto N Shigematsu M Ezaki M Hino S Hashimoto M Okuhara M Kohsaka H Imanaka 《The Journal of antibiotics》1990,43(5):449-455
FR112123 is a new oligopeptide antibiotic produced by Streptomyces viridochromogenes No. 7587. The structure of FR112123 is elucidated as N-(N6-(N2-glycyl-L-glutaminyl)-D-lysyl)-D-alanine (1) by spectroscopic and chemical evidence. It resembles a partial structure of peptidoglycan in bacteria. The compound has a superior activity against an Escherichia coli mutant sensitive to inhibitors of cell wall synthesis, although it has a weak activity against the parent strain. These suggest that FR112123 might act on the biosynthesis of bacterial cell wall. 相似文献
59.
Kenji Nakamura Masayuki Sada Kenzo Setojima Hirofumi Yamamoto Toshiyuki Ueki Masumi Sada 《Journal of Hepato-Biliary-Pancreatic Surgery》1997,4(4):449-452
The purpose of this paper is to describe our recent experience in performing laparoscopic cholecystectomies of which we performed
1904, from January 1991 to May 1997, at our private hospital, mainly to treat cholecystolithiasis. The patients included 1563
with gallbladder stones (82.0%), 82 with cholecystocholedocholithiasis (4.3%), 104 with adenomyomatosis (5.5%), 132 with polyps
(6.9%), and 23 with gallbladder cancer (1.3%). A difficult pericholecystic dissection led to conversion to open surgery in
61 patients. The average operation time was 63 min. Bile duct injury or cystic artery bleeding occurred in 3 patients with
acute cholecystitis, and small intestine injury occurred in 1 patient, while bile leakage or a right subphrenic abscess occurred
in 6 patients postoperatively. Although this series included 69 patients with previous upper abdominal surgery, 14 with liver
cirrhosis, 267 with a nonvisualized gallbladder, and 148 with acute cholecystitis, the overall conversion rate was only 3.2%
and morbidity only 0.5%. Although almost all patients with cholelithiasis are now considered potential candidates for a laparoscopic
cholecystectomy, difficulties during cholecystectomy have been encountered in patients with acute cholecystitis. Surgeons
should thus be fully prepared to convert to open surgery whenever difficulties are encountered, in order to avoid complication. 相似文献
60.
Hideki SATO Kazuyuki KANEMASA Masamichi TANINO Tsugihiro KIMURA Kenji MAENOU Shouji MITSUFUJI Kyouhei MARUYAMA Tadashi KODAMA Kei KASHIMA Naoki TERAMAE Susumu FUKUI Keizo KAGAWA 《Digestive endoscopy》1996,8(1):41-45
Abstract: Biliobiliary fistula is a rare clinical entity. The case of a 72 year old female, who presented with epigastric pain and jaundice, is detailed herein. Endoscopic retrograde cholangiopancreatography (ERCP) revealed two stones, one each in the common bile duct and the gallbladder. Continuous endoscopic nasobiliary drainage (ENBD) was performed to relieve obstructive jaundice. Further study with contrast medium administered via the ENBD tube revealed a fistula between the neck of the gallbladder and the common bile duct. The cystic duct was intact. A stone was considered to have migrated into the common bile duct through the fistula. A diagnosis of biliobiliary fistula, Corlette type I was made. However, in this particular case, a biliobiliary fistula was noted at a site below the junction of the cystic duct and common bile duct. Removal of the gallbladder stones was followed by cholecystectomy. The common bile duct was then repaired by utilizing a T-tube. No evidence of malignancy was recognized in the resected gallbladder specimen. In the one year to date since surgery, the patient has been asymptomatic and without signs of biliary disease. 相似文献