Outcomes of and factors influencing the arthroscopic treatment of rotator cuff injury with the patient in the lateral-lying and beach chair positions

To compare the postoperative effects of arthroscopy for rotator cuff injury with patients in the lateral-lying position (LLP) and beach chair position (BCP), and to identify factors influencing these effects.Data from patients with rotator cuff injuries who underwent shoulder arthroscopy in the LLP (n = 115, 53.24%) or BCP (n = 101, 46.76%) between January 2013 and 2016 and were followed for >3 years were analyzed. The American Shoulder and Elbow Surgeons shoulder score, University of California at Los Angeles shoulder score (UCLASS), and visual analog scale (VAS) score were used to evaluate patients’ shoulder function and pain preoperatively and at the last follow-up examination. The abduction and lateral rotation angles were measured. The influences of patient characteristics were compared between the LLP and BCP subgroups defined by UCLASSs (excellent, good, acceptable, poor).Postoperative injury characteristics, UCLASSs, and VAS scores were better in the LLP group than in the BCP group (all P < .05). Among patients with good UCLASSs, preoperative pain duration was longer in the LLP group than in the BCP group (P < .05); among those with acceptable UCLASSs, this duration was longer in the BCP group than in the LLP group (P < .05). The preoperative flexion angle differed between groups (P < .05). Among patients with excellent and good UCLASSs, the postoperative external rotation angle was greater in the LLP group than in the BCP group (P < .05). The LLP group contained more excellent UCLASSs than did the BCP group (P < .05). It also contained more small, medium, and large tear cases than did the BCP group (all P < .05).The effect of arthroscopy for rotator cuff injury was better when the operation was performed with the patient in the LLP. Either position is suitable for the arthroscopic treatment of partial rotator cuff tears. The LLP is more suitable in cases of small and medium-sized tears and those with large preoperative lateral rotation angles. The BCP should be used for patients with large preoperative flexion angles.     

NHL血清LDH及β2-微球蛋白测定的临床意义

目的探讨非霍奇金淋巴瘤(NHL)患者血清乳酸脱氢酶(LDH)和β2-微球蛋白(β2-MG)测定的临床意义.方法分别采用速率法和放免法测定69例NHL患者血清LDH和β2-MG值.结果正常组与NHL 组,Ⅰ～Ⅱ与Ⅲ～Ⅳ期,无全身症状组(A组)与有全身症状组(B组),无骨髓浸润组与有骨髓浸润组以及化疗后与化疗前(CR组或PR组)患者的LDH值和β2-MG值相比,后组均明显高于前组,差异有统计学意义(P＜0.05),而无效组化疗前后差异无统计学意义(P＞0.05).结论血清LDH和β2-MG水平可作为NHL患者分期、有否骨髓浸润、预后及疗效判断的辅助指标.     

黄山市肺吸虫第二中间宿主—溪蟹感染调查

目的了解黄山市肺吸虫第二中间宿主-溪蟹感染情况,为全市防控肺吸虫病提供科学依据。方法 根据水系分布特点和以往调查情况确定调查点,在调查点内根据当地环境,选择调查溪流,采用人工和地笼捕捉境内溪流中的溪蟹,实验室解剖镜下检查肺吸虫囊蚴。计算溪蟹的感染率及囊蚴感染指数。结果调查了11个乡镇的12个行政村,捕捉溪蟹275只,检出阳性溪蟹57只,阳性率20.73%。感染度平均每只蟹3.51个,感染性溪蟹每克含囊蚴数0.958个,蟹囊蚴感染指数为0.194 06。随着溪蟹体重的增加,阳性率和感染度随之增高(r_(阳性率)=0.905,P0.02;r_(感染度)=0.929,P0.01)。雄性溪蟹的阳性率和感染度均高于雌性溪蟹(x~2=136.53,P0.01)。不同水系溪蟹阳性率差异有统计学意义(x~2=7.70,P0.05)。结论 调查结果表明黄山市仍存在着较高的肺吸虫病流行因素。新安江水系流域是今后肺吸虫病防治的重点区域。     

Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A

The major facilitator superfamily (MFS) is the largest family of secondary active transporters and is present in all life kingdoms. Detailed structural basis of the substrate transport and energy-coupling mechanisms of these proteins remain to be elucidated. YajR is a putative proton-driven MFS transporter found in many Gram-negative bacteria. Here we report the crystal structure of Escherichia coli YajR at 3.15 Å resolution in an outward-facing conformation. In addition to having the 12 canonical transmembrane helices, the YajR structure includes a unique 65-residue C-terminal domain which is independently stable. The structure is unique in illustrating the functional role of “sequence motif A.” This highly conserved element is seen to stabilize the outward conformation of YajR and suggests a general mechanism for the conformational change between the inward and outward states of the MFS transporters.     

牡荆苷的药理作用研究进展

牡荆苷为许多传统中药中的有效成分之一,是一种黄酮类化合物.近年来,有关牡荆苷药用价值方面研究逐渐被人们关注,大量研究表明其具有抗肿瘤、抗氧化、抗病毒、抗炎、抗菌、降压和解痉等药理作用.本文对近年来牡荆苷的药理作用研究进展进行了综述,为其在临床应用提供建议和参考.     

一氧化氮部分介导槲皮素的抗高血压作用

目的：观察槲皮素的抗高血压作用及其可能机制。方法：两肾一夹复制肾性高血压大鼠模型。采用Griess反应测定NO含量．血浆及主动脉一氧化氮合酶（NOS）活性应用试剂盘测定，主动脉iNOS mRNA表达分析运用RT-PCR方法。结果：槲皮素能明显降低肾性高血压大鼠血压（174．811．9 vs 142．816．2mmHg．P〈0．01）。并能显著提高血浆NO产量及主动脉NOS活性。槲皮素能增加iNOS mRNA表达。槲皮素的这些作用可被L-NAME部分抑制。结论：槲皮素具有抗高血压作用，其机制部分涉及NO通路。     

SPE-HPLC法测定护肾胶囊中马钱苷的含量

目的采用饱和流出式固相萃取(SPE)法制备护肾胶囊供试品溶液,用高效液相色谱法测定其中马钱苷的含量。方法ZorbaxSB-C18柱(250mm×4.6mm,5μm),以四氢呋喃-甲醇-乙腈-0.5g·L-1磷酸溶液(1∶8∶4∶87)为流动相,流速为1mL·min-1,检测波长为236nm。结果马钱苷在0.08～0.80μg范围内线性关系良好,r=0.9998,平均回收率为99.4%,RSD为2.2%。结论该方法简便快速、灵敏度高、有效除去药物基质保护色谱柱,可用于护肾胶囊中马钱苷的含量测定。     

2005年～2008年我院抗菌药物使用调查分析

目的：通过对我院4年抗菌药物使用情况调查分析,进一步了解我院抗菌药物的应用特点和趋势,从而规范管理、促进抗菌药物的合理应用.方法：根据我院药库微机管理系统提供的2005～2008年抗菌药物出库数据,采用WHO推荐的限定日剂量（DDD）,计算出各药的用药频度（DDDs）并由此进行分类排序、合并统计分析.结果：抗菌药销售金额在逐年增加,4年来我院抗菌药物消耗金额占药品总消耗金额比例的平均值26.54%,临床使用抗菌药以头孢菌素为主.结论：抗菌药物用药结构基本合理,仍存在个别品种用药过度、集中的问题,还需进一步加强管理,促进相关措施的落实.     

对《中药注册管理补充规定》中与药理毒理相关内容的认识和理解

研读国家食品药品监督管理局2008年颁布的《中药注册管理补充规定》,从其对中药复方制剂、改剂型制剂、药效学的对照研究、有效部位的对比、安全性试验与药理毒理相关的其他内容几个方面的要求,论述了进一步的认识和理解。