全文获取类型
收费全文 | 9750篇 |
免费 | 616篇 |
国内免费 | 79篇 |
专业分类
耳鼻咽喉 | 68篇 |
儿科学 | 254篇 |
妇产科学 | 260篇 |
基础医学 | 1362篇 |
口腔科学 | 142篇 |
临床医学 | 759篇 |
内科学 | 2508篇 |
皮肤病学 | 121篇 |
神经病学 | 1434篇 |
特种医学 | 391篇 |
外科学 | 880篇 |
综合类 | 16篇 |
一般理论 | 3篇 |
预防医学 | 415篇 |
眼科学 | 133篇 |
药学 | 759篇 |
中国医学 | 10篇 |
肿瘤学 | 930篇 |
出版年
2024年 | 19篇 |
2023年 | 157篇 |
2022年 | 114篇 |
2021年 | 490篇 |
2020年 | 267篇 |
2019年 | 379篇 |
2018年 | 414篇 |
2017年 | 308篇 |
2016年 | 373篇 |
2015年 | 385篇 |
2014年 | 545篇 |
2013年 | 623篇 |
2012年 | 826篇 |
2011年 | 862篇 |
2010年 | 495篇 |
2009年 | 447篇 |
2008年 | 628篇 |
2007年 | 575篇 |
2006年 | 565篇 |
2005年 | 495篇 |
2004年 | 359篇 |
2003年 | 305篇 |
2002年 | 270篇 |
2001年 | 44篇 |
2000年 | 40篇 |
1999年 | 57篇 |
1998年 | 45篇 |
1997年 | 37篇 |
1996年 | 37篇 |
1995年 | 24篇 |
1994年 | 26篇 |
1993年 | 15篇 |
1992年 | 16篇 |
1991年 | 27篇 |
1990年 | 23篇 |
1989年 | 25篇 |
1988年 | 27篇 |
1987年 | 16篇 |
1986年 | 15篇 |
1985年 | 7篇 |
1984年 | 9篇 |
1983年 | 7篇 |
1982年 | 3篇 |
1981年 | 10篇 |
1980年 | 5篇 |
1979年 | 8篇 |
1978年 | 5篇 |
1977年 | 3篇 |
1967年 | 2篇 |
1966年 | 5篇 |
排序方式: 共有10000条查询结果,搜索用时 328 毫秒
11.
Daniela Brizzolara Anna Chilosi Paola Cipriani Gloria Di Filippo Filippo Gasperini Sara Mazzotti Chiara Pecini Pierluigi Zoccolotti 《Cognitive and behavioral neurology》2006,19(3):141-149
OBJECTIVE: The study aims to verify whether phonologic and rapid automatized naming (RAN) deficits are present and associated in Italian dyslexic children and whether they differentially affect dyslexics with and without a history of previous language delay (LD). BACKGROUND: According to the phonologic core deficit hypothesis, dyslexia may stem from impairment of the representation and manipulation of phonemes and may be closely associated with oral language deficits. However, deficits in tasks not requiring fine-grained phonologic representations, such as RAN, have also been described in dyslexic children. METHODS: Thirty-seven children were selected on the basis of a reading deficit and were assigned to 2 groups according to whether or not they had a history of early LD as determined retrospectively by parental report. A battery of reading and writing, verbal working memory, metaphonologic, RAN, and visual search tests were administered. RESULTS: RAN deficits were shared by most dyslexics (with and without a history of LD), whereas phonologic deficits were mainly associated with a previous LD. This last condition did not result in a more profound impairment of reading and writing decoding skills. CONCLUSION: In a shallow orthography such as Italian, RAN, not phonologic deficits, may represent the main cognitive marker of developmental dyslexia. 相似文献
12.
Osvaldo Chiara Stefania Cimbanassi Alessio Pitidis Sergio Vesconi 《World journal of emergency surgery : WJES》2006,1(1):12-7
Preventable trauma deaths are defined as deaths which could be avoided if optimal care has been delivered. Studies on preventable
trauma deaths have been accomplished initially with panel reviews of pre-hospital and hospital charts. However, several investigators
questioned the reliability and validity of this method because of low reproducibility of implicit judgments when they are
made by different experts. Nevertheless, number of studies were published all around the world and ultimately gained some
credibility, particularly in regions where comparisons were made before and after trauma system implementation with a resultant
fall in mortality. During the last decade of century the method of comparing observed survival with probability of survival
calculated from large trauma registries has obtained popularity. Preventable trauma deaths were identified as deaths occurred
notwithstanding a high calculated probability of survival. In recent years, preventable trauma deaths studies have been replaced
by population-based studies, which use databases representative of overall population, therefore with high epidemiologic value.
These databases contain readily available information which carry out the advantage of objectivity and large numbers. Nowadays,
population-based researches provide the strongest evidence regarding the effectiveness of trauma systems and trauma centers
on patient outcomes. 相似文献
13.
Hemolytic anemia during pegylated IFN-alpha2b plus ribavirin treatment for chronic hepatitis C: ribavirin is not always the culprit. 总被引:1,自引:0,他引:1
Ivan Gentile Chiara Viola Laura Reynaud Francesco Borrelli Raimondo Cerini Rocco Ciampi Marcello Piazza Guglielmo Borgia 《Journal of interferon & cytokine research》2005,25(5):283-285
A 53-year-old woman admitted to our department for histologically proven chronic hepatitis C had previously been treated with pegylated interferon-alpha2b (PEG-IFN) plus ribavirin. Combination therapy had been withdrawn after 5 weeks because of severe anemia (hemoglobin 8.2 g/dl) despite a reduction in ribavirin dose. A second liver biopsy showed moderate chronic hepatitis with portoportal and portocentral bridges (Ishak score: grading 14/18, staging 4-5/6). Consequently, the patient was retreated with 1.5 microg/kg body weight weekly PEG-IFN and 1000 mg/day ribavirin. Ribavirin was withdrawn about 3 months later because of anemia. After 1 month of PEG-IFN alone, hemoglobin had decreased further to reach 7.9 g/dl; consequently IFN was stopped. An elevated reticulocyte count, indirect bilirubin concentration, and lactic dehydrogenase (LDH) concentration, and a positive direct Coombs test (IgG3, C3d also for panagglutinant irregular antibodies on eluate) led us to diagnose autoimmune hemolytic anemia (AHA). The patient received 1 mg/kg body weight/day prednisone, and all parameters normalized within 20 days. This is the first case of IFN-related AHA during PEG-IFN plus ribavirin therapy. Physicians should be aware that PEG-IFN can be the cause of AHA during a ribavirin-containing regimen for chronic hepatitis C. 相似文献
14.
Rebecca Voltan Arianna Castaldello Egidio Brocca-Cofano Rita De Michele Chiara Triulzi Giuseppe Altavilla Luisa Tondelli Michele Laus Katia Sparnacci Eva Reali Riccardo Gavioli Barbara Ensoli Antonella Caputo 《Vaccine》2009
Cationic block copolymers spontaneously assemble via electrostatic interactions with DNA molecules in aqueous solution giving rise to micellar structures that protect the DNA from enzymatic degradation both in vitro and in vivo. In addition, we have previously shown that they are safe, not immunogenic and greatly increased antigen-specific CTL responses following six intramuscular inoculations of a very low dose (1 μg) of the vaccine DNA as compared to naked DNA. Nevertheless, they failed to elicit detectable humoral responses against the antigen. To gain further insight in the potential application of this technology, here we show that a shorter immunization protocol based on two DNA intramuscular inoculations of 1 μg of DNA delivered by these copolymers and a protein boost elicits in mice broad (both humoral and cellular) and long-lasting responses and increases the antigen-specific Th1-type T cell responses and CTLs as compared to priming with naked DNA. These results indicate that cationic block copolymers represent a promising adjuvant and delivery technology for DNA vaccination strategies aimed at combating intracellular pathogens. 相似文献
15.
16.
17.
Nicoletta Desideri Isabella Sestili Maria Luisa Stein Stefano Manarini Giuseppe Dell'Elba Chiara Cerletti 《Archiv der Pharmazie》1997,330(4):100-106
6-[(4-Quinolinyl)oxy]hexanoic acids and the corresponding esters were designed and synthesized as inhibitors of the production of arachidonic acid metabolites. The inhibitory activities were assayed in vitro by evaluation of serum leukotriene B4 and thromboxane B2 production. While all 6-[(4-quinolinyl)oxy]hexanoic acids and their esters proved to be inactive, the N-alkyl-4-quinolones, obtained as by-products in their synthesis, were found to be a new class of leukotriene biosynthesis inhibitors. 相似文献
18.
Previous exposure to a dopaminergic agonist (priming) strongly potentiates contralateral turning behaviour in response to D1 and D2 agonists in unilaterally 6-hydroxydopamine-lesioned rats. In order to study the influence of priming on the behavioural interaction of D1 and D2 receptors, we examined the effect of selective D1 and D2 receptor blockade on the contralateral turning induced by the mixed D2/D2 agonist apomorphine in drug-naive and primed 6-hydroxydopamine-lesioned rats. In drug-naive rats, apomorphine induced a dose-related, apparently monophasic rotation curve. Administration of selective D1 (SCH 23390) or D2 (raclopride) antagonists abolished the contralateral turning induced by 0.1 mg/kg of apomorphine and partially inhibited that induced by 0.5 mg/kg. In primed rats low doses of apomorphine (0.05 mg/kg) induced an apparently monophasic contralateral turning which was reduced by D1 receptor blockade and completely abolished by D2 receptor blockade; a higher dose of apomorphine (0.1 mg/kg) instead elicited a biphasic (two-peak) pattern of rotation. After this dose of the agonist, blockade of D1 or D2 receptors abolished the second peak of rotation but, while D1 blockade reduced the total number of turns, D2 blockade failed to do so. Quantitative analysis of the interaction between D1 and D2 receptors in the overall turning effect, as well as in the time-course of turning behaviour, indicates that D1 and D2 receptors interact not only positively but also negatively. After higher doses of apomorphine, both negative and positive interactions take place sequentially during the time-course of apomorphine action and provide a clue for explaining the two-peak pattern of rotation observed after apomorphine in rats previously exposed to the drug. 相似文献
19.
F Fraschini D Esposti G Demartini F Scaglione V Lucini M Mariani B Stankov M Mancia 《Psychoneuroendocrinology》1991,16(5):417-422
Male Sprague-Dawley rats injected (i.p.) at 1500h with L-acetyl-carnitine in doses of 10, 30 or 90 mg/kg exhibited a notable increase in their pineal and serum melatonin content 1 hr later. Likewise, L-acetyl-carnitine administered in the same dose range induced a significant increase of pineal and serum melatonin content in rats treated at 0100h, following exposure of 30 min to bright white light to suppress endogenous melatonin. Under in vitro experimental conditions, however, 60 min of coincubation of isolated rat pineal glands with L-acetyl-carnitine (10(-5) M) did not result in an elevation in melatonin accumulated in the incubation medium. These results demonstrate that, in vivo, L-acetyl-carnitine can exert a modulatory action on synthesis and release of melatonin, possibly by modifying noradrenergic transmission and signal transduction in the pineal gland. 相似文献
20.
Endovascular repair for concomitant multilevel aortic disease. 总被引:2,自引:0,他引:2
Patrizio Castelli Roberto Caronno Gabriele Piffaretti Matteo Tozzi Chiara Lomazzi Domenico Laganà Gianpaolo Carrafiello Salvatore Cuffari 《European journal of cardio-thoracic surgery》2005,28(3):478-482
OBJECTIVE: Patients with multilevel aortic disease represent a small subgroup with the need for extensive surgical treatment at considerable risk. We present our experience of endovascular exclusion for simultaneous thoracic and abdominal aortic disease in four patients. METHODS: Between January 2002 and January 2005, four patients underwent endovascular repair for simultaneous thoracic and abdominal aortic disease. Mean age was 69+/-10 years (range, 60-81). Thoracic lesions included penetrating aortic ulcer (n=2, ruptured=1), atherosclerotic aneurysm (n=1), and chronic type B dissection (n=1). Abdominal aortic disease included atherosclerotic infrarenal (n=3) and juxtarenal (n=1) aortic aneurysms. Thoracic aortic stent-grafts had been the following: Excluder/TAG (n=3) or Talent (n=1) straight tube devices. Abdominal aortic stent-grafts used were as following: Excluder (n=3) or Zenith (n=1). All patients were followed-up with CT-angiography and chest X-rays 1, 4, 12 months after the procedure, and once per year thereafter. RESULTS: Stent-graft deployment was technically successful in all cases. Intraoperative mortality was not observed. Mean procedure time was 94+/-34 min (range, 70-145). Early postoperative complications occurred in one patient that developed acute renal failure but dialysis was not required. Mean hospitalisation was 8+/-5 days (range, 4-15). Late death occurred in one patient for an undetected ruptured thoracic type 1 endoleak. All three survivors are currently well 16.5 months (range, 3-36) after surgery. No neurological complications developed. CONCLUSION: Simultaneous abdominal and thoracic endovascular repair for multilevel aortic disease is feasible and could be a viable alternative in high-risk patients, who otherwise may not be suitable candidates for conventional repair. 相似文献