全文获取类型
收费全文 | 1441篇 |
免费 | 150篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 40篇 |
儿科学 | 53篇 |
妇产科学 | 23篇 |
基础医学 | 146篇 |
口腔科学 | 12篇 |
临床医学 | 194篇 |
内科学 | 337篇 |
皮肤病学 | 32篇 |
神经病学 | 115篇 |
特种医学 | 97篇 |
外科学 | 257篇 |
综合类 | 61篇 |
一般理论 | 1篇 |
预防医学 | 65篇 |
眼科学 | 25篇 |
药学 | 45篇 |
中国医学 | 6篇 |
肿瘤学 | 88篇 |
出版年
2021年 | 10篇 |
2020年 | 6篇 |
2019年 | 6篇 |
2018年 | 8篇 |
2017年 | 13篇 |
2016年 | 14篇 |
2015年 | 21篇 |
2014年 | 23篇 |
2013年 | 39篇 |
2012年 | 36篇 |
2011年 | 37篇 |
2010年 | 55篇 |
2009年 | 45篇 |
2008年 | 51篇 |
2007年 | 62篇 |
2006年 | 57篇 |
2005年 | 53篇 |
2004年 | 48篇 |
2003年 | 55篇 |
2002年 | 62篇 |
2001年 | 40篇 |
2000年 | 33篇 |
1999年 | 35篇 |
1998年 | 30篇 |
1997年 | 49篇 |
1996年 | 41篇 |
1995年 | 23篇 |
1994年 | 37篇 |
1993年 | 35篇 |
1992年 | 54篇 |
1991年 | 31篇 |
1990年 | 42篇 |
1989年 | 65篇 |
1988年 | 38篇 |
1987年 | 34篇 |
1986年 | 34篇 |
1985年 | 29篇 |
1984年 | 15篇 |
1983年 | 17篇 |
1982年 | 21篇 |
1981年 | 15篇 |
1980年 | 17篇 |
1979年 | 25篇 |
1978年 | 21篇 |
1977年 | 27篇 |
1976年 | 17篇 |
1975年 | 15篇 |
1974年 | 10篇 |
1973年 | 13篇 |
1972年 | 7篇 |
排序方式: 共有1597条查询结果,搜索用时 15 毫秒
11.
12.
13.
14.
Donor-specific transfusion was performed with and without cyclosporine between haplomismatched relatives prior to living-donor renal transplantation. Red cell antigen mismatching was not taken as a contraindication to DST. Of 80 patients included in the trial; eleven were ABO-mismatched, 15 were Rh(D)-mismatched, and a further 11 were transfused in the presence of atypical red cell antibodies (anti-D, -C, -Fya, -Kell -N, -H/I -I, -P1, -Wra). Patients were randomized to receive cyclosporine (10 mg/kg) daily during DST or not (control group). The presence of atypical red cell antibodies, with the exception of Rh anti-D, did not appear to influence DST or renal transplantation. DST did not act as a primary stimulus to Rh anti-D production but stimulated preexisting anti D levels. ABO mismatching did not appear to influence DST or subsequent renal transplantation except in one group A [corrected] patient who received group O [corrected] blood and cyclosporine. This patient developed a severe, but self-limiting, autoimmune hemolytic anemia due to auto-anti A antibodies. A similar group A patient in the control group developed an auto-antibody with no clinical sequelae. The influence of cyclosporine on the development of this auto-antibody is uncertain. We conclude that, with the exception of preexisting anti-D antibodies, minor red cell antigen disparities should not preclude pretransplant conditioning with donor-specific transfusions. 相似文献
15.
R C Bone 《Clinical microbiology reviews》1993,6(1):57-68
Gram-negative sepsis is an increasingly common problem, with up to 300,000 cases occurring each year in the United States alone. Despite the ongoing development of new antibiotics, mortality from gram-negative sepsis remains unacceptably high. To stimulate earlier therapeutic intervention by physicians, a new set of broad definitions has been proposed to define the systemic inflammatory response characteristic of sepsis. In this review, the signs and symptoms of this progressive, injurious process are reviewed and its management is discussed, as are the mechanisms by which bacterial endotoxin triggers the biochemical events that lead to such serious complications as shock, adult respiratory distress syndrome, and disseminated intravascular coagulation. These events often occur even when appropriate antimicrobial therapy has been instituted. An increased understanding of the structure of endotoxin and its role in the development of sepsis, together with advances in hybridoma technology, has led to the development of monoclonal antibodies that bind to endotoxin and significantly attenuate its adverse effects. These agents promise to substantially reduce the morbidity and mortality associated with gram-negative sepsis. 相似文献
16.
17.
18.
19.
Results obtained from gated equilibrium blood pool (GBP) studies are not only dependent on intrinsic variations, but also on the way in which images are acquired and analysed. The aim of this study was to investigate factors which could affect left ventricular time-activity curves. Temporal resolution was studied by comparing studies of 20 and 40 frames beat-1. Forty frames per beat resulted in a mean left ventricular ejection fraction of 0.48 compared to 0.46 for 20 frames beat-1. The mean difference of 0.02 was significant (P less than 0.01) as was the mean difference in maximum emptying rate (MER = 0.28, P less than 0.01) and in maximum filling rate (MFR = 0.38, P less than 0.01). No significant differences in ejection fraction (EF) values were found between acquisitions made in list and frame mode, but the mean differences for MER = 0.03 (P less than 0.05) and MFR = 0.01 (P less than 0.02) were significant. For patient repositioning and intra-observer variations no significant differences were found. In patients with normal EF values (greater than 0.5) no significant differences were found in the inter-observer study. In patients with anterior myocardial infarction (AMI), significant differences were found in EF, MER and MFR (EF = 0.02, P less than 0.001; MER = 0.2, P less than 0.01; MFR = 0.24, P less than 0.01). Significant differences were found in all values when comparing a semi-automatic method of evaluation with two automatic methods. In conclusion the results from this study suggest that acceptable reproducibility can be achieved in GBP studies, provided the method of analysis is not changed between studies. 相似文献
20.
Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset confirmed Alzheimer's disease 总被引:5,自引:2,他引:5
The allelic frequency of the gene for the K variant of
butyrylcholinesterase (BCHE-K) was 0.17 in 74 subjects with late-onset (age
> 65 years) histopathologically diagnosed Alzheimer's disease (AD),
which was higher than the frequencies in 104 elderly control subjects
(0.09), in 14 early-onset cases of confirmed AD (0.07) and in 29 confirmed
cases of other dementia (0.10). The association of BCHE-K with late-onset
AD was limited to carriers of the epsilon 4 allele of the apolipoprotein E
gene (APOE), among whom the presence of BCHE-K gave an odds ratio of
confirmed late-onset AD of 6.9 (95% C.I. 1.65-29) in subjects > 65 years
and of 12.8 (1.9-86) in subjects > 75 years. In APOE epsilon 4 carriers
over 75 years, only 1/22 controls, compared with 10/24 confirmed late-onset
AD cases, had BCHE-K. We suggest that BCHE-K, or a nearby gene on
chromosome 3, acts in synergy with APOE epsilon 4 as a susceptibility gene
for late-onset AD.
相似文献