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991.
The open-artery hypothesis states that myocardial reperfusion, even if late for myocardial salvage, provides benefits and prevents adverse cardiac remodeling. While observational data in humans regarding the deleterious impact of a permanent infarct-related artery occlusion and the benefits of spontaneous reperfusion are quite consistent, the reports regarding late revascularization are inconclusive in order to prove such a hypothesis. The observational studies tend to have selection biases, while randomized trials to date are too small to be conclusive. Moreover, the pathophysiological mechanisms underlying presumed benefits of reperfusion are still unclear. However, although the open-artery hypothesis remains unproven, the current evidence suggesting benefits calls for additional studies. Limitations of ischemic left ventricular dilatation and myopathy could markedly reduce cardiovascular morbidity and mortality after acute myocardial infarction. 相似文献
992.
993.
Piero Barbanti MD PhD Luisa Fofi MD Licia Grazzi MD Fabrizio Vernieri MD Cecilia Camarda MD Paola Torelli MD Sabina Cevoli MD PhD Antonio Russo MD PhD Francesco Bono MD Cinzia Finocchi MD Renata Rao MD Stefano Messina MD Roberto De Simone MD Nicola Vanacore MD PhD Stefano Bonassi PhD ERT IRON Study Group 《Headache》2021,61(6):936-950
994.
Piero Barbanti MD PhD Cinzia Aurilia MD Sabina Cevoli MD PhD Gabriella Egeo MD PhD Luisa Fofi MD Roberta Messina MD Antonio Salerno MD Paola Torelli MD Maria Albanese MD PhD Antonio Carnevale MD Francesco Bono MD Domenico D'Amico MD Massimo Filippi MD Claudia Altamura MD PhD Fabrizio Vernieri MD EARLY Study Group 《Headache》2021,61(9):1351-1363
995.
Juan Ramn Tejedor Clara Bueno Meritxell Vinyoles Paolo Petazzi Antonio Agraz-Doblas Isabel Cobo Raúl Torres-Ruiz Gustavo F. Bayn Raúl F. Prez Sara Lpez-Tamargo Francisco Gutierrez-Agüera Pablo Santamarina-Ojeda Manuel Ramírez-Orellana Michela Bardini Giovanni Cazzaniga Paola Ballerini Pauline Schneider Ronald W. Stam Ignacio Varela Mario F. Fraga Agustín F. Fernndez Pablo Menndez 《The Journal of clinical investigation》2021,131(13)
996.
997.
Antonio Preti Marcello Vellante Mersia Gabbrielli Veronica Lai Tamara Muratore Elisa Pintus Mirra Pintus Sara Sanna Rosanna Scanu Debora Tronci Irene Corrias Donatella Rita Petretto Mauro Giovanni Carta 《Journal of affective disorders》2013
Background
The Temperament Evaluation of Memphis, Pisa, Paris and San Diego – Autoquestionnaire (TEMPS-A) is a widely used self-reported tool aimed at measuring the affective temperaments that define the bipolar spectrum, with cyclothymic, depressive, irritable, hyperthymic, and anxious subscales. Confirmatory factor analysis (CFA) was rarely used to confirm the expected five-factor model. Measurement invariance was never tested.Methods
Cross-sectional, survey design involving 649 Italian college students (males: 47%). The short 39-item TEMPS-A and the 12-item General Health Questionnaire (GHQ-12) were used as measures of the affective temperaments and of psychological distress, respectively. CFA was applied to the TEMPS-A. Measurement invariance by gender, age and levels of psychological distress on the GHQ-12 was calculated with the establishment of subsequent equivalence constraints in the model parameters across groups.Results
The expected five-factor model had the best fit for all CFA indexes. Configural, metric and scalar invariance of the five-factor model of the TEMPS-A was proved across gender, age and levels of psychological distress of the participants. The hyperthymic temperament subscale has low or no links with the other affective temperament subscales, which were interrelated with medium to large effect sizes.Limitations
College students might be not representative of the general population. No information on the clinical status of the students was available beyond self-report data.Conclusion
The study proved the measurement invariance of the (short) TEMPS-A, which is a pre-requisite to compare groups or individuals in cross-sectional and longitudinal surveys. Generalizability cannot be assumed without replication of the findings in clinical samples. 相似文献998.
Introduction
The activating MICA/NKG2D interaction is involved in the response of intraepithelial lymphocytes (IELs) in coeliac disease (CD). The aim of this study was to investigate the expression of NKG2D ligands (MICA, MICB), IL-15 and NKG2D receptor in gut mucosa of CD patients, and the correlation with the severity of histological damage.Patients and methods
Intestinal biopsies from 20 CD patients and five healthy controls were selected. All patients were positive for anti-transglutaminase 2 antibodies and for DQ2 or DQ8. Patients were divided into two groups according to their grade of mucosal impairment: ten each with mild and severe mucosal damage (MMD and SMD, respectively). The expression of proposed genes was determined at mRNA level. MICA expression was also determined by immunohistochemistry.Results
Overexpression of MICA and MICB was observed in biopsies from coeliac patients compared to healthy controls (P < 0.001). Nevertheless, the expression was considerably higher in the group of patients with MMD (P < 0.0001) than in those with SMD. The levels of NKG2D receptor and IL-15 were also higher in patients than in controls, but no relationship with the severity of the mucosal lesion was found.Conclusions
Our results suggest that NKG2D ligands may play an important role during the onset of the inflammatory process in the early stages of the development of coeliac disease. 相似文献999.
Rosanna Tortelli Francesca Luisa Conforti Rosa Cortese Eustachio D'Errico Eugenio Distaso Rosalucia Mazzei Carmine Ungaro Angela Magariello Antonio Gambardella Giancarlo Logroscino Isabella Laura Simone 《Neurobiology of aging》2013
Copper-zinc superoxide dismutase-1 (SOD1) is the second most common mutated gene in amyotrophic lateral sclerosis (ALS). To date more than 150 missense mutations of SOD1 have been reported. The objective of this study was to describe a novel SOD1 mutation and its phenotypic expression. We describe a 74-year-old Caucasian man who began to complain of progressive weakness and atrophy of the right hand and over 10 months developed a severe tetraparesis, with atrophies of upper and lower limbs and neck muscles, dysphagia, and dyspnea that led to percutaneous endoscopic gastrostomy and tracheotomy. A diagnosis of ALS was made. Genetic analysis identified a heterozygous mutation in exon 4 of SOD1 that results in the amino acid substitution from arginine to cysteine at position 115 (p.R115C). We identified a novel pathogenic SOD1 mutation in a patient with a very rapid disease progression and aggressive phenotype providing additional information on the wide range of SOD1 mutations in apparently sporadic ALS and confirming the possibility of a strong genotype-phenotype correlation for distinct SOD1 mutations. 相似文献
1000.
Luca Passamonti Francesco Fera Alessandro Tessitore Antonio Russo Antonio Cerasa Cecilia M. Gioia Maria R. Monsurrò Raffaella Migliaccio Gioacchino Tedeschi Aldo Quattrone 《Neurobiology of aging》2013
Previous studies have shown that affective symptoms are part of the clinical picture in amyotrophic lateral sclerosis (ALS), the most common motor neuron disorder in elderly people. Diffuse neurodegeneration of limbic regions (e.g., prefrontal cortex [PFC], amygdala) was demonstrated in ALS post-mortem, although the mechanisms of emotional dysregulation in ALS in vivo remain unclear. Using functional imaging, we assessed the brain responses to emotional faces in 11 cognitively unimpaired ALS patients and 12 healthy controls (HCs). We tested whether regional activities and connectivity patterns in the limbic system differed between ALS patients and HCs and whether the variability in clinical measures modulated the neuroimaging data. Relative to HCs, ALS patients displayed greater activation in a series of PFC areas and altered left amygdala–PFC connectivity. Anxiety modulated the right amygdala–PFC connectivity in HCs but not in ALS patients. Reduced right premotor cortex activity and altered left amygdala–supplementary motor area connectivity were associated with longer disease duration and greater disease severity, respectively. Our findings demonstrate dysfunctions of the limbic system in ALS patients at early stages of the disease, and extend our knowledge about the interplay between emotional brain areas and the regions traditionally implicated in motor control. 相似文献