全文获取类型
收费全文 | 18680篇 |
免费 | 793篇 |
国内免费 | 85篇 |
专业分类
耳鼻咽喉 | 221篇 |
儿科学 | 317篇 |
妇产科学 | 202篇 |
基础医学 | 2320篇 |
口腔科学 | 570篇 |
临床医学 | 1167篇 |
内科学 | 4271篇 |
皮肤病学 | 241篇 |
神经病学 | 1656篇 |
特种医学 | 785篇 |
外科学 | 3248篇 |
综合类 | 71篇 |
预防医学 | 590篇 |
眼科学 | 266篇 |
药学 | 1320篇 |
中国医学 | 31篇 |
肿瘤学 | 2282篇 |
出版年
2023年 | 81篇 |
2021年 | 287篇 |
2020年 | 172篇 |
2019年 | 206篇 |
2018年 | 305篇 |
2017年 | 206篇 |
2016年 | 267篇 |
2015年 | 280篇 |
2014年 | 414篇 |
2013年 | 481篇 |
2012年 | 811篇 |
2011年 | 828篇 |
2010年 | 510篇 |
2009年 | 459篇 |
2008年 | 785篇 |
2007年 | 794篇 |
2006年 | 835篇 |
2005年 | 871篇 |
2004年 | 852篇 |
2003年 | 817篇 |
2002年 | 845篇 |
2001年 | 792篇 |
2000年 | 787篇 |
1999年 | 728篇 |
1998年 | 261篇 |
1997年 | 202篇 |
1996年 | 206篇 |
1995年 | 146篇 |
1994年 | 129篇 |
1993年 | 122篇 |
1992年 | 474篇 |
1991年 | 422篇 |
1990年 | 381篇 |
1989年 | 473篇 |
1988年 | 386篇 |
1987年 | 340篇 |
1986年 | 364篇 |
1985年 | 345篇 |
1984年 | 252篇 |
1983年 | 162篇 |
1982年 | 79篇 |
1979年 | 144篇 |
1978年 | 106篇 |
1977年 | 89篇 |
1975年 | 82篇 |
1974年 | 74篇 |
1973年 | 76篇 |
1970年 | 72篇 |
1969年 | 94篇 |
1967年 | 87篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
Toshifumi Murashita Keishu Yasuda Yoshiro Matsui Norihiko Shiiya Shigeyuki Sasaki Makoto Sakuma 《Surgery today》1997,27(4):368-372
A successful replacement of the aorta from the ascending aorta to the supraceliac abdominal aorta in one operation is herein reported. The patient was 66-year-old woman who had DeBakey type I chronic aortic dissection with a pre-disseminated intravascular coagulation (DIC) condition. The image diagnosis revealed a markedly enlarged false lumen with a narrow true lumen in the ascending aorta extending to the diaphragm level while below the diaphragm level, the aortic dilatation was mild. The operation was performed through both a thoracoabdominal incision and a median sternotomy to expose the whole thoracic aorta, and the aorta was replaced from the ascending aorta to the supraceliac abdominal aorta. Selective cerebral perfusion was used for cerebral protection and this was a useful adjunct since no time limitations were thus required during repair of the aortic arch. Although the patient developed several complications postoperatively, she eventually recovered and was discharged from the hospital without any neurological disorders. 相似文献
102.
Yasuo Aoki Souji Maruo Akira Arakawa Sadao Sasaki Seiki Hori 《Journal of orthopaedic science》1997,2(6):434-441
Changes in the nerve fibers of the spinal cord were studied in rat experimental epidural tumor models. Light microscopy showed
demyelinization in all with rats paraparesis and paraplegia. Cross-sectional views of nerve fibers stained with 3,3dipentyloxacarbo-cyanine
iodide, obtained by confocal laser scanning microscopy, showed distorted, shrunken fibers with a low fluorescence intensity.
Changes in the electrolyte contents of nerve fibers were studied by electron probe X-ray microanalysis. The K concentration
in axons and the myelin sheath was increased in the paraparesis group, but was decreased in the paraplegia group. These findings
suggest that, in the paraparesis group, compression of the spinal cord damaged cell membrane channels, which subsequently
caused an increase in intracellular K, a decline in the action potential, and low-intensity fluorescence of nerve fibers.
On the other hand, in the paraplegia group, destruction of cell membranes caused a decrease in intracellular K until it approached
the extracellular level. This reduced both the action potential and the fluorescence intensity. As Ca and Mg concentrations
in both axons and the myelin sheath increased in relation to the severity of neurologic damage, it appears that these electrolytes
may also play an important role in damage to nerve fibers. 相似文献
103.
Shigeyuki Sasaki Keishu Yasuda James D. McCully Joseph LoCicero III 《Surgery today》1997,27(12):1154-1159
The purpose of this study was to develop an isolated, pulsatile blood-perfused rat lung model that allows us to evaluate the
preserved lung functions. Lungs isolated from Sprague-Dawley rats, were perfused with venous whole blood by either a pulsatile
or constant flow. The effuent was continuously deoxygenated with a 95% N2/5% CO2 gas mixture. Airway resistance, lung compliance, elastic work, flow resistive work, pulmonary vascular resistance, and blood
gas analysis were assessed. Pressor responses toN
G
-monomethyl-l-arginine (l-NMMA) were compared between pulsatile and constant blood flow. At a flow of 0.1 ml/g body weight/min, pulsatile perfusion
allowed for stable perfusion at least for 2h (mean 162.5±15.1 min) with stable aerodynamic and hemodynamic variables including
blood gas tensions, whereas constant perfusion resulted in immediate lung failure. Whenl-NMMA was added to the perfusate, the mean pulmonary artery pressure did not show any change in the constant flow (6.0±2.6%
increase), but did show a significant increase in the pulsatile flow (45±11% increase). Pulsatile blood flow reduced the pulmonary
vascular resistance relative to the constant flow and allowed for a 2-h perfusion period to evaluate the lung function. The
vasorelaxant mechanism in the pulsatile perfusion is related in part to the endothelial-dependent relaxation observed in the
nitric oxide pathway.
Presented in part at the 79th, Annual Clinical Congress of the American College of Surgeons (ACS) held in San Francisco, CA
USA, 1993. 相似文献
104.
M Hatsu T Sasaki S Gomi Y Kodama M Sezaki S Inouye S Kondo 《The Journal of antibiotics》1992,45(3):325-330
The structure of a new antitumor antibiotic SF2575, has been determined by spectroscopic analyses of the antibiotic and its alkaline degradation products. The relative stereochemistry has been confirmed by X-ray crystallographic analysis. The antibiotic has a 2-naphthacenecarboxamide carbon skelton which is structurally related to the tetracycline antibiotics and it is unique by bearing C-glycoside, salicyclic acid and angelic acid moieties. 相似文献
105.
S Yamabayashi T Yamamoto T Sasaki S Tsukahara 《The British journal of ophthalmology》1988,72(11):852-855
A case of 'low tension glaucoma' with primary empty sella is reported. The visual field defect and optic disc change were characteristic of glaucoma. The intraocular pressure was within normal limits. X-ray examination and the metrizamide-CF procedures revealed a primary empty sella. The coexistence of 'low tension glaucoma' and empty sella is discussed. 相似文献
106.
107.
S Sasaki H Yoshida Y Matsui M Sakuma K Yasuda T Tanabe H Chouji 《Kyobu geka. The Japanese journal of thoracic surgery》1990,43(2):106-113
The diagnostic value of cine magnetic resonance imaging (cine-MRI) was evaluated in 10 patients with disease of great vessels. The parameters necessary to decide the appropriate treatment, such as presence and extension of intimal flap, DeBakey type classification, identification of the entry, differentiation between true and false lumen, and between thrombosis and slow flow were demonstrated in all patients with dissecting aortic aneurysm. However, abdominal aortic branches could not be demonstrated enough by cine-MRI, therefore conventional AOG was necessary to choose the operative procedure in these cases. In patients with thoracic aortic aneurysm (TAA), cine-MRI was valuable in demonstrating both blood flow and thrombus in the lumen of aneurysm, and AOG was thought to be unnecessary in most cases. Cine-MRI is a promising new technique for the evaluation of diseases of great vessels. 相似文献
108.
109.
T Motohiro Y Yoshinaga H Sasaki K Oda M Aramaki A Kawakami K Tanaka T Koga Y Shimada Y Sakata 《The Japanese journal of antibiotics》1989,42(2):465-494
It has been known that clarithromycin (TE-031, A-56268), a new macrolide antibiotic (ML), achieves higher concentrations in blood, is better excreted into urine and is better distributed into various tissues than conventional MLs. We investigated the pharmacokinetics of TE-031 in children upon oral administration of the drug in the following method. TE-031 granular preparation with a potency of 100 mg/g was given to 6 boys (5 years 4 months-14 years 0 month) with dose levels of 5 mg/kg and 10 mg/kg for each 3 boys. A tablet preparation with each tablet containing 50 mg of TE-031 was administered to 4 boys and 2 girls (8 years 5 months-11 years 6 months) with dose level of 2 tablets (i.e., 100 mg) and 3 tablets (i.e., 150 mg) for each 3 children. All administrations were done at 30 minutes before meal. Then, to conduct a cross-over test, the granule preparation was given orally to the 3 children mentioned above who was given 2 tablets and the 1 of 3 cases that were given 3 tablets at the same dose levels (100 mg and 150 mg) respectively. A bioassay was used to determine concentrations in blood of active antibiotic compounds and an high performance liquid chromatography (HPLC) was used to determine unchanged TE-031 and its main metabolite, M-5. Urinary concentrations of active antibiotic compounds were also determined by the bioassay and the HPLC was used to determine concentrations and proportions of unchanged TE-031 and its metabolites, M-1, M-4, M-5, M-6 and M-7 to figure out the urinary recovery rate in the first 6 hours. The results of these experiments are summarized as follows. 1. As was mentioned above, TE-031 was administered orally to 2 groups of children at dose levels of 5 mg/kg and 10 mg/kg, respectively. Mean serum levels of total active antibiotic compounds reached their maximum in 1 and 2 hours for the 5 mg/kg and the 10 mg/kg dosage groups, respectively, at 1.28 and 3.62 micrograms/ml, respectively. Mean half lives of serum concentrations in the 2 groups were quite similar, with values of at 2.1 and 2.0 hours, respectively. Mean serum concentrations of unchanged TE-031 determined by the HPLC method reached their peaks in 1 hour after administration in either of the 5 and 10 mg/kg dosage groups at peak levels of 0.65 micrograms/ml and 2.67 micrograms/ml, respectively. Thus, dose-response relationships were observed with TE-031 and M-5.(ABSTRACT TRUNCATED AT 400 WORDS) 相似文献
110.
Seiji Kinugasa Shuichi Tachibana Manpei Kawakami Tatsuhiko Orino Ryuichi Yamamoto Shinjiro Sasaki 《Surgery today》1998,28(3):335-338
(Received for publication on Nov. 14, 1996; accepted on May 12, 1997) 相似文献